DegronMD

Uniprot ID: Q9H2K0

Source protein: Translation initiation factor IF-3, mitochondrial

Source gene: MTIF3

Class: DEG_APCC_DBOX_1

Location: 139:147

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5183

ASA_SCORE: 107.9111

COIL: 0.1173

CONS_SCORE: 0.7012

DSS_SCORE: 0.564

HELIX: 0.8857

FCONS_SCORE: 1.0123

RIG_SCORE: 0.7797

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G154R	TCGA-50-5946	LUAD	TCGA	ERQRLREME	DEG_APCC_DBOX_1	0.1389
p.G154R	DO24556	LUAD	ICGC	ERQRLREME	DEG_APCC_DBOX_1	0.1389
p.L130F	TCGA-AX-A2HC	UCEC	TCGA	ERQRLREME	DEG_APCC_DBOX_1	0.0833
p.L130F	DO41572	UCEC	ICGC	ERQRLREME	DEG_APCC_DBOX_1	0.0833
p.A149S	TCGA-CG-5721	STAD	TCGA	ERQRLREME	DEG_APCC_DBOX_1	0.2778
p.A149S	DO38192	STAD	ICGC	ERQRLREME	DEG_APCC_DBOX_1	0.2778
p.Q141H	TCGA-CQ-A4C6	HNSC	TCGA	ERQRLREME	DEG_APCC_DBOX_1	0.647
p.Q141H	DO49047	HNSC	ICGC	ERQRLREME	DEG_APCC_DBOX_1	0.647
p.Q129K	TCGA-XE-A8H5	TGCT	TCGA	ERQRLREME	DEG_APCC_DBOX_1	0.0556
p.R144K	DO230320	COCA	ICGC	ERQRLREME	DEG_APCC_DBOX_1	0.6126
p.Q138K	DO229038	LICA	ICGC	ERQRLREME	DEG_APCC_DBOX_1	0.3056
p.M146I	DO231681	LINC	ICGC	ERQRLREME	DEG_APCC_DBOX_1	0.6507
p.A149V	SIDM00120	Prostate Carcinoma	GDSC	ERQRLREME	DEG_APCC_DBOX_1	0.2778
p.A149V	ACH-000659	Lung Cancer	CCLE	ERQRLREME	DEG_APCC_DBOX_1	0.2778
p.A149V	ACH-000979	Prostate Cancer	CCLE	ERQRLREME	DEG_APCC_DBOX_1	0.2778
p.A149V	ACH-001386	Lung Cancer	CCLE	ERQRLREME	DEG_APCC_DBOX_1	0.2778
p.A149V	DU-145	prostate	COSMIC	ERQRLREME	DEG_APCC_DBOX_1	0.2778
p.R140Q	SIDM00918	Ovarian Carcinoma	GDSC	ERQRLREME	DEG_APCC_DBOX_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H2K0	Translation initiation factor IF-3, mitochondrial	DEG_APCC_DBOX_1	139:147	ERQRLREME	APC,CDC20,FZR1	0.5183	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons