DegronMD - Q9H2K0(MTIF3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G154R	TCGA-50-5946	LUAD	TCGA	ERQRLREME	DEG_APCC_DBOX_1	139:147	Mutation rewiring degron network	0.1389
p.G154R	DO24556	LUAD	ICGC	ERQRLREME	DEG_APCC_DBOX_1	139:147	Mutation rewiring degron network	0.1389
p.G25C	TCGA-66-2766	LUSC	TCGA	KRLTLQTVK	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.0556
p.G25C	DO27747	LUSC	ICGC	KRLTLQTVK	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.0556
p.L130F	TCGA-AX-A2HC	UCEC	TCGA	ERQRLREME	DEG_APCC_DBOX_1	139:147	Mutation rewiring degron network	0.0833
p.L130F	DO41572	UCEC	ICGC	ERQRLREME	DEG_APCC_DBOX_1	139:147	Mutation rewiring degron network	0.0833
p.A149S	TCGA-CG-5721	STAD	TCGA	ERQRLREME	DEG_APCC_DBOX_1	139:147	Mutation rewiring degron network	0.2778
p.A149S	DO38192	STAD	ICGC	ERQRLREME	DEG_APCC_DBOX_1	139:147	Mutation rewiring degron network	0.2778
p.Q141H	TCGA-CQ-A4C6	HNSC	TCGA	ERQRLREME	DEG_APCC_DBOX_1	139:147	Mutation altering degron motif	0.647
p.Q141H	DO49047	HNSC	ICGC	ERQRLREME	DEG_APCC_DBOX_1	139:147	Mutation altering degron motif	0.647
p.S16F	TCGA-FD-A6TA	BLCA	TCGA	KRLTLQTVK	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.3056
p.S16F	DO49753	BLCA	ICGC	KRLTLQTVK	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.3056
p.Q129K	TCGA-XE-A8H5	TGCT	TCGA	ERQRLREME	DEG_APCC_DBOX_1	139:147	Mutation rewiring degron network	0.0556
p.R144K	DO230320	COCA	ICGC	ERQRLREME	DEG_APCC_DBOX_1	139:147	Mutation altering degron motif	0.6126
p.Q138K	DO229038	LICA	ICGC	ERQRLREME	DEG_APCC_DBOX_1	139:147	Mutation rewiring degron network	0.3056
p.M146I	DO231681	LINC	ICGC	ERQRLREME	DEG_APCC_DBOX_1	139:147	Mutation altering degron motif	0.6507
p.A149V	SIDM00120	Prostate Carcinoma	GDSC	ERQRLREME	DEG_APCC_DBOX_1	139:147	Mutation rewiring degron network	0.2778
p.A149V	ACH-000659	Lung Cancer	CCLE	ERQRLREME	DEG_APCC_DBOX_1	139:147	Mutation rewiring degron network	0.2778
p.A149V	ACH-000979	Prostate Cancer	CCLE	ERQRLREME	DEG_APCC_DBOX_1	139:147	Mutation rewiring degron network	0.2778
p.A149V	ACH-001386	Lung Cancer	CCLE	ERQRLREME	DEG_APCC_DBOX_1	139:147	Mutation rewiring degron network	0.2778
p.A149V	DU-145	prostate	COSMIC	ERQRLREME	DEG_APCC_DBOX_1	139:147	Mutation rewiring degron network	0.2778
p.R140Q	SIDM00918	Ovarian Carcinoma	GDSC	ERQRLREME	DEG_APCC_DBOX_1	139:147	Mutation altering degron motif	0.7329

Kaplan plot for MTIF3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MTIF3

UniProt ID: Q9H2K0

Entrez ID: 219402

Protein name: Translation initiation factor IF-3, mitochondrial (IF-3(Mt)) (IF-3Mt) (IF3(mt)) (IF3mt)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MTIF3 in