DegronMD

Uniprot ID: Q5JTD0

Source protein: Tight junction-associated protein 1

Source gene: TJAP1

Class: DEG_APCC_DBOX_1

Location: 495:503

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9592

ASA_SCORE: 81.3556

COIL: 0.627

CONS_SCORE: 0.3963

DSS_SCORE: 0.7432

HELIX: 0.3339

FCONS_SCORE: 1.0244

RIG_SCORE: 0.6858

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R504M	TCGA-CG-4465	STAD	TCGA	ERQSLLPIN	DEG_APCC_DBOX_1	0.3056
p.G505D	TCGA-D1-A103	UCEC	TCGA	ERQSLLPIN	DEG_APCC_DBOX_1	0.2778
p.S513F	TCGA-FS-A1ZK	SKCM	TCGA	ERQSLLPIN	DEG_APCC_DBOX_1	0.0556
p.S513F	SIDM02027	Colorectal Carcinoma	GDSC	ERQSLLPIN	DEG_APCC_DBOX_1	0.0556
p.E495Q	TCGA-XF-AAMQ	BLCA	TCGA	ERQSLLPIN	DEG_APCC_DBOX_1	0.5633
p.E485Q	DO51934	BLCA	ICGC	ERQSLLPIN	DEG_APCC_DBOX_1	0.0556
p.P513S	DO222441	ESCA	ICGC	ERQSLLPIN	DEG_APCC_DBOX_1	0.0556
p.R486L	DO27939	ORCA	ICGC	ERQSLLPIN	DEG_APCC_DBOX_1	0.0833
p.S503F	DO37474	SKCM	ICGC	ERQSLLPIN	DEG_APCC_DBOX_1	0.7982
p.R494M	DO38627	STAD	ICGC	ERQSLLPIN	DEG_APCC_DBOX_1	0.3056
p.G495D	DO42312	UCEC	ICGC	ERQSLLPIN	DEG_APCC_DBOX_1	0.7198
p.R504G	SIDM00158	Glioblastoma	GDSC	ERQSLLPIN	DEG_APCC_DBOX_1	0.3056
p.R494G	ACH-000623	Brain Cancer	CCLE	ERQSLLPIN	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JTD0	Tight junction-associated protein 1	DEG_APCC_DBOX_1	495:503	ERQSLLPIN	APC,CDC20,FZR1	0.9592	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons