DegronMD - Q5JTD0(TJAP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T432I	TCGA-55-8506	LUAD	TCGA	GRDALPELQ	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.25
p.R504M	TCGA-CG-4465	STAD	TCGA	ERQSLLPIN	DEG_APCC_DBOX_1	495:503	Mutation rewiring degron network	0.3056
p.G505D	TCGA-D1-A103	UCEC	TCGA	ERQSLLPIN	DEG_APCC_DBOX_1	495:503	Mutation rewiring degron network	0.2778
p.S513F	TCGA-FS-A1ZK	SKCM	TCGA	ERQSLLPIN	DEG_APCC_DBOX_1	495:503	Mutation rewiring degron network	0.0556
p.S513F	SIDM02027	Colorectal Carcinoma	GDSC	ERQSLLPIN	DEG_APCC_DBOX_1	495:503	Mutation rewiring degron network	0.0556
p.D437N	TCGA-G9-6339	PRAD	TCGA	GRDALPELQ	DEG_APCC_DBOX_1	435:443	Mutation altering degron motif	0.5821
p.E495Q	TCGA-XF-AAMQ	BLCA	TCGA	ERQSLLPIN	DEG_APCC_DBOX_1	495:503	Mutation altering degron motif	0.5633
p.E485Q	DO51934	BLCA	ICGC	ERQSLLPIN	DEG_APCC_DBOX_1	495:503	Mutation rewiring degron network	0.0556
p.P513S	DO222441	ESCA	ICGC	ERQSLLPIN	DEG_APCC_DBOX_1	495:503	Mutation rewiring degron network	0.0556
p.D444H	DO26520	LUSC	ICGC	GRDALPELQ	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.3056
p.R486L	DO27939	ORCA	ICGC	ERQSLLPIN	DEG_APCC_DBOX_1	495:503	Mutation rewiring degron network	0.0833
p.D427N	DO49766	PRAD	ICGC	GRDALPELQ	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.1111
p.S503F	DO37474	SKCM	ICGC	ERQSLLPIN	DEG_APCC_DBOX_1	495:503	Mutation altering degron motif	0.7982
p.R494M	DO38627	STAD	ICGC	ERQSLLPIN	DEG_APCC_DBOX_1	495:503	Mutation rewiring degron network	0.3056
p.G495D	DO42312	UCEC	ICGC	ERQSLLPIN	DEG_APCC_DBOX_1	495:503	Mutation altering degron motif	0.7198
p.R444H	SIDM00216	Colorectal Carcinoma	GDSC	GRDALPELQ	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.3056
p.R444H	SNU-175	large intestine	COSMIC	GRDALPELQ	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.3056
p.R431C	SIDM01051	Ovarian Carcinoma	GDSC	GRDALPELQ	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.2222
p.R431C	EFO-27	ovary	COSMIC	GRDALPELQ	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.2222
p.A429T	SIDM00537	Colorectal Carcinoma	GDSC	GRDALPELQ	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.1667
p.A429T	GP5d	large intestine	COSMIC	GRDALPELQ	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.1667
p.R444C	SIDM01608	Endometrial Carcinoma	GDSC	GRDALPELQ	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.3056
p.H445R	SIDM01611	Endometrial Carcinoma	GDSC	GRDALPELQ	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.2778
p.R504G	SIDM00158	Glioblastoma	GDSC	ERQSLLPIN	DEG_APCC_DBOX_1	495:503	Mutation rewiring degron network	0.3056
p.R494G	ACH-000623	Brain Cancer	CCLE	ERQSLLPIN	DEG_APCC_DBOX_1	495:503	Mutation rewiring degron network	0.3056
p.R434C	ACH-000990	Endometrial/Uterine Cancer	CCLE	GRDALPELQ	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.3056
p.H435R	ACH-000996	Endometrial/Uterine Cancer	CCLE	GRDALPELQ	DEG_APCC_DBOX_1	435:443	Mutation altering degron motif	0.8244
p.R434H	SNU-175	large intestine	COSMIC	GRDALPELQ	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TJAP1

UniProt ID: Q5JTD0

Entrez ID: 93643

Protein name: Tight junction-associated protein 1 (Protein incorporated later into tight junctions) (Tight junction protein 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TJAP1 in