DegronMD

Uniprot ID: Q5JTD0

Source protein: Tight junction-associated protein 1

Source gene: TJAP1

Class: DEG_APCC_DBOX_1

Location: 435:443

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7836

ASA_SCORE: 69.2444

COIL: 0.5244

CONS_SCORE: 0.4502

DSS_SCORE: 0.5019

HELIX: 0.4418

FCONS_SCORE: 1.0803

RIG_SCORE: 0.7113

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T432I	TCGA-55-8506	LUAD	TCGA	GRDALPELQ	DEG_APCC_DBOX_1	0.25
p.D437N	TCGA-G9-6339	PRAD	TCGA	GRDALPELQ	DEG_APCC_DBOX_1	0.5821
p.D444H	DO26520	LUSC	ICGC	GRDALPELQ	DEG_APCC_DBOX_1	0.3056
p.D427N	DO49766	PRAD	ICGC	GRDALPELQ	DEG_APCC_DBOX_1	0.1111
p.R444H	SIDM00216	Colorectal Carcinoma	GDSC	GRDALPELQ	DEG_APCC_DBOX_1	0.3056
p.R444H	SNU-175	large_intestine	COSMIC	GRDALPELQ	DEG_APCC_DBOX_1	0.3056
p.R431C	SIDM01051	Ovarian Carcinoma	GDSC	GRDALPELQ	DEG_APCC_DBOX_1	0.2222
p.R431C	EFO-27	ovary	COSMIC	GRDALPELQ	DEG_APCC_DBOX_1	0.2222
p.A429T	SIDM00537	Colorectal Carcinoma	GDSC	GRDALPELQ	DEG_APCC_DBOX_1	0.1667
p.A429T	GP5d	large_intestine	COSMIC	GRDALPELQ	DEG_APCC_DBOX_1	0.1667
p.R444C	SIDM01608	Endometrial Carcinoma	GDSC	GRDALPELQ	DEG_APCC_DBOX_1	0.3056
p.H445R	SIDM01611	Endometrial Carcinoma	GDSC	GRDALPELQ	DEG_APCC_DBOX_1	0.2778
p.R434C	ACH-000990	Endometrial/Uterine Cancer	CCLE	GRDALPELQ	DEG_APCC_DBOX_1	0.3056
p.H435R	ACH-000996	Endometrial/Uterine Cancer	CCLE	GRDALPELQ	DEG_APCC_DBOX_1	0.8244
p.R434H	SNU-175	large_intestine	COSMIC	GRDALPELQ	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JTD0	Tight junction-associated protein 1	DEG_APCC_DBOX_1	435:443	GRDALPELQ	APC,CDC20,FZR1	0.7836	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons