DegronMD

Uniprot ID: Q14147

Source protein: Probable ATP-dependent RNA helicase DHX34

Source gene: DHX34

Class: DEG_APCC_DBOX_1

Location: 717:725

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6826

ASA_SCORE: 90.0444

COIL: 0.0742

CONS_SCORE: 0.4558

DSS_SCORE: 0.612

HELIX: 0.9241

FCONS_SCORE: 1.1377

RIG_SCORE: 0.7079

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R734H	TCGA-B5-A3FC	UCEC	TCGA	ERRALHQLK	DEG_APCC_DBOX_1	0.0833
p.R734H	DO41871	UCEC	ICGC	ERRALHQLK	DEG_APCC_DBOX_1	0.0833
p.R734H	SIDM01194	Hepatocellular Carcinoma	GDSC	ERRALHQLK	DEG_APCC_DBOX_1	0.0833
p.S708C	TCGA-D3-A8GC	SKCM	TCGA	ERRALHQLK	DEG_APCC_DBOX_1	0.0833
p.S708C	DO50281	SKCM	ICGC	ERRALHQLK	DEG_APCC_DBOX_1	0.0833
p.D707E	DO23276	LINC	ICGC	ERRALHQLK	DEG_APCC_DBOX_1	0.0556
p.R715C	DO218856	SKCA	ICGC	ERRALHQLK	DEG_APCC_DBOX_1	0.2778
p.R715C	DO38535	STAD	ICGC	ERRALHQLK	DEG_APCC_DBOX_1	0.2778
p.R726C	DO38727	STAD	ICGC	ERRALHQLK	DEG_APCC_DBOX_1	0.3056
p.Y709H	SIDM01951	Colorectal Carcinoma	GDSC	ERRALHQLK	DEG_APCC_DBOX_1	0.1111
p.R719Q	SIDM00516	Melanoma	GDSC	ERRALHQLK	DEG_APCC_DBOX_1	0.6218
p.A732T	SIDM01335	Kidney Carcinoma	GDSC	ERRALHQLK	DEG_APCC_DBOX_1	0.1389
p.A732T	ACH-000513	Kidney Cancer	CCLE	ERRALHQLK	DEG_APCC_DBOX_1	0.1389
p.R719W	SIDM01460	Glioma	GDSC	ERRALHQLK	DEG_APCC_DBOX_1	0.7523
p.R719W	ACH-000592	Brain Cancer	CCLE	ERRALHQLK	DEG_APCC_DBOX_1	0.7523

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14147	Probable ATP-dependent RNA helicase DHX34	DEG_APCC_DBOX_1	717:725	ERRALHQLK	APC,CDC20,FZR1	0.6826	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons