DegronMD - Q14147(DHX34)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R98H	TCGA-44-6778	LUAD	TCGA	YRINLSVLG	DEG_APCC_DBOX_1	104:112	Mutation rewiring degron network	0.1667
p.R98H	DO25603	LUAD	ICGC	YRINLSVLG	DEG_APCC_DBOX_1	104:112	Mutation rewiring degron network	0.1667
p.R103C	TCGA-AX-A1CE	UCEC	TCGA	YRINLSVLG	DEG_APCC_DBOX_1	104:112	Mutation rewiring degron network	0.3056
p.R103C	DO42280	UCEC	ICGC	YRINLSVLG	DEG_APCC_DBOX_1	104:112	Mutation rewiring degron network	0.3056
p.R105H	TCGA-B5-A1MW	UCEC	TCGA	YRINLSVLG	DEG_APCC_DBOX_1	104:112	Mutation altering degron motif	0.8244
p.R105H	DO42913	UCEC	ICGC	YRINLSVLG	DEG_APCC_DBOX_1	104:112	Mutation altering degron motif	0.8244
p.R734H	TCGA-B5-A3FC	UCEC	TCGA	ERRALHQLK	DEG_APCC_DBOX_1	717:725	Mutation rewiring degron network	0.0833
p.R734H	DO41871	UCEC	ICGC	ERRALHQLK	DEG_APCC_DBOX_1	717:725	Mutation rewiring degron network	0.0833
p.R734H	SIDM01194	Hepatocellular Carcinoma	GDSC	ERRALHQLK	DEG_APCC_DBOX_1	717:725	Mutation rewiring degron network	0.0833
p.S109F	TCGA-BB-4225	HNSC	TCGA	YRINLSVLG	DEG_APCC_DBOX_1	104:112	Mutation altering degron motif	0.6871
p.S109F	DO14264	HNSC	ICGC	YRINLSVLG	DEG_APCC_DBOX_1	104:112	Mutation altering degron motif	0.6871
p.D101E	TCGA-BK-A0C9	UCEC	TCGA	YRINLSVLG	DEG_APCC_DBOX_1	104:112	Mutation rewiring degron network	0.25
p.D101E	DO41253	UCEC	ICGC	YRINLSVLG	DEG_APCC_DBOX_1	104:112	Mutation rewiring degron network	0.25
p.D101N	TCGA-D1-A17Q	UCEC	TCGA	YRINLSVLG	DEG_APCC_DBOX_1	104:112	Mutation rewiring degron network	0.25
p.D101N	DO41903	UCEC	ICGC	YRINLSVLG	DEG_APCC_DBOX_1	104:112	Mutation rewiring degron network	0.25
p.S708C	TCGA-D3-A8GC	SKCM	TCGA	ERRALHQLK	DEG_APCC_DBOX_1	717:725	Mutation rewiring degron network	0.0833
p.S708C	DO50281	SKCM	ICGC	ERRALHQLK	DEG_APCC_DBOX_1	717:725	Mutation rewiring degron network	0.0833
p.T115M	TCGA-G2-A2EO	BLCA	TCGA	YRINLSVLG	DEG_APCC_DBOX_1	104:112	Mutation blocking phosphorylation signal	0.6944
p.T115M	DO456	BLCA	ICGC	YRINLSVLG	DEG_APCC_DBOX_1	104:112	Mutation blocking phosphorylation signal	0.6944
p.R116Q	TCGA-PG-A6IB	UCEC	TCGA	YRINLSVLG	DEG_APCC_DBOX_1	104:112	Mutation rewiring degron network	0.2222
p.R116Q	DO52419	UCEC	ICGC	YRINLSVLG	DEG_APCC_DBOX_1	104:112	Mutation rewiring degron network	0.2222
p.R116W	DO230326	COCA	ICGC	YRINLSVLG	DEG_APCC_DBOX_1	104:112	Mutation rewiring degron network	0.2222
p.Y104C	DO234168	ESAD	ICGC	YRINLSVLG	DEG_APCC_DBOX_1	104:112	Mutation altering degron motif	0.5976
p.D707E	DO23276	LINC	ICGC	ERRALHQLK	DEG_APCC_DBOX_1	717:725	Mutation rewiring degron network	0.0556
p.L111F	DO227531	PACA	ICGC	YRINLSVLG	DEG_APCC_DBOX_1	104:112	Mutation altering degron motif	0.6981
p.R715C	DO218856	SKCA	ICGC	ERRALHQLK	DEG_APCC_DBOX_1	717:725	Mutation rewiring degron network	0.2778
p.R715C	DO38535	STAD	ICGC	ERRALHQLK	DEG_APCC_DBOX_1	717:725	Mutation rewiring degron network	0.2778
p.R726C	DO38727	STAD	ICGC	ERRALHQLK	DEG_APCC_DBOX_1	717:725	Mutation rewiring degron network	0.3056
p.Y709H	SIDM01951	Colorectal Carcinoma	GDSC	ERRALHQLK	DEG_APCC_DBOX_1	717:725	Mutation rewiring degron network	0.1111
p.G117D	SIDM00855	Other Sarcomas	GDSC	YRINLSVLG	DEG_APCC_DBOX_1	104:112	Mutation rewiring degron network	0.1944
p.G117D	SIDM00032	Bladder Carcinoma	GDSC	YRINLSVLG	DEG_APCC_DBOX_1	104:112	Mutation rewiring degron network	0.1944
p.G117D	SIDM00539	Esophageal Carcinoma	GDSC	YRINLSVLG	DEG_APCC_DBOX_1	104:112	Mutation rewiring degron network	0.1944
p.G117D	SIDM00097	Breast Carcinoma	GDSC	YRINLSVLG	DEG_APCC_DBOX_1	104:112	Mutation rewiring degron network	0.1944
p.G117D	SIDM00257	Neuroblastoma	GDSC	YRINLSVLG	DEG_APCC_DBOX_1	104:112	Mutation rewiring degron network	0.1944
p.G117D	SIDM00490	Glioma	GDSC	YRINLSVLG	DEG_APCC_DBOX_1	104:112	Mutation rewiring degron network	0.1944
p.G117D	SIDM01387	Small Cell Lung Carcinoma	GDSC	YRINLSVLG	DEG_APCC_DBOX_1	104:112	Mutation rewiring degron network	0.1944
p.R719Q	SIDM00516	Melanoma	GDSC	ERRALHQLK	DEG_APCC_DBOX_1	717:725	Mutation altering degron motif	0.6218
p.R98C	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	YRINLSVLG	DEG_APCC_DBOX_1	104:112	Mutation rewiring degron network	0.1667
p.R98C	ACH-000705	Lung Cancer	CCLE	YRINLSVLG	DEG_APCC_DBOX_1	104:112	Mutation rewiring degron network	0.1667
p.R98C	ACH-001113	Lung Cancer	CCLE	YRINLSVLG	DEG_APCC_DBOX_1	104:112	Mutation rewiring degron network	0.1667
p.R98C	ACH-002156	Lung Cancer	CCLE	YRINLSVLG	DEG_APCC_DBOX_1	104:112	Mutation rewiring degron network	0.1667
p.R98C	LC-1-sq	lung	COSMIC	YRINLSVLG	DEG_APCC_DBOX_1	104:112	Mutation rewiring degron network	0.1667
p.A732T	SIDM01335	Kidney Carcinoma	GDSC	ERRALHQLK	DEG_APCC_DBOX_1	717:725	Mutation rewiring degron network	0.1389
p.A732T	ACH-000513	Kidney Cancer	CCLE	ERRALHQLK	DEG_APCC_DBOX_1	717:725	Mutation rewiring degron network	0.1389
p.R719W	SIDM01460	Glioma	GDSC	ERRALHQLK	DEG_APCC_DBOX_1	717:725	Mutation altering degron motif	0.7523
p.R719W	ACH-000592	Brain Cancer	CCLE	ERRALHQLK	DEG_APCC_DBOX_1	717:725	Mutation altering degron motif	0.7523

Kaplan plot for DHX34 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DHX34

UniProt ID: Q14147

Entrez ID: 9704

Protein name: Probable ATP-dependent RNA helicase DHX34 (EC 3.6.4.13) (DEAH box protein 34) (DExH-box helicase 34)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DHX34 in