DegronMD

Uniprot ID: Q14147

Source protein: Probable ATP-dependent RNA helicase DHX34

Source gene: DHX34

Class: DEG_APCC_DBOX_1

Location: 104:112

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8043

ASA_SCORE: 54.5333

COIL: 0.5956

CONS_SCORE: 0.3743

DSS_SCORE: 0.4174

HELIX: 0.3539

FCONS_SCORE: 1.1067

RIG_SCORE: 0.7738

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R98H	TCGA-44-6778	LUAD	TCGA	YRINLSVLG	DEG_APCC_DBOX_1	0.1667
p.R98H	DO25603	LUAD	ICGC	YRINLSVLG	DEG_APCC_DBOX_1	0.1667
p.R103C	TCGA-AX-A1CE	UCEC	TCGA	YRINLSVLG	DEG_APCC_DBOX_1	0.3056
p.R103C	DO42280	UCEC	ICGC	YRINLSVLG	DEG_APCC_DBOX_1	0.3056
p.R105H	TCGA-B5-A1MW	UCEC	TCGA	YRINLSVLG	DEG_APCC_DBOX_1	0.8244
p.R105H	DO42913	UCEC	ICGC	YRINLSVLG	DEG_APCC_DBOX_1	0.8244
p.S109F	TCGA-BB-4225	HNSC	TCGA	YRINLSVLG	DEG_APCC_DBOX_1	0.6871
p.S109F	DO14264	HNSC	ICGC	YRINLSVLG	DEG_APCC_DBOX_1	0.6871
p.D101E	TCGA-BK-A0C9	UCEC	TCGA	YRINLSVLG	DEG_APCC_DBOX_1	0.25
p.D101E	DO41253	UCEC	ICGC	YRINLSVLG	DEG_APCC_DBOX_1	0.25
p.D101N	TCGA-D1-A17Q	UCEC	TCGA	YRINLSVLG	DEG_APCC_DBOX_1	0.25
p.D101N	DO41903	UCEC	ICGC	YRINLSVLG	DEG_APCC_DBOX_1	0.25
p.T115M	TCGA-G2-A2EO	BLCA	TCGA	YRINLSVLG	DEG_APCC_DBOX_1	0.6944
p.T115M	DO456	BLCA	ICGC	YRINLSVLG	DEG_APCC_DBOX_1	0.6944
p.R116Q	TCGA-PG-A6IB	UCEC	TCGA	YRINLSVLG	DEG_APCC_DBOX_1	0.2222
p.R116Q	DO52419	UCEC	ICGC	YRINLSVLG	DEG_APCC_DBOX_1	0.2222
p.R116W	DO230326	COCA	ICGC	YRINLSVLG	DEG_APCC_DBOX_1	0.2222
p.Y104C	DO234168	ESAD	ICGC	YRINLSVLG	DEG_APCC_DBOX_1	0.5976
p.L111F	DO227531	PACA	ICGC	YRINLSVLG	DEG_APCC_DBOX_1	0.6981
p.G117D	SIDM00855	Other Sarcomas	GDSC	YRINLSVLG	DEG_APCC_DBOX_1	0.1944
p.G117D	SIDM00032	Bladder Carcinoma	GDSC	YRINLSVLG	DEG_APCC_DBOX_1	0.1944
p.G117D	SIDM00539	Esophageal Carcinoma	GDSC	YRINLSVLG	DEG_APCC_DBOX_1	0.1944
p.G117D	SIDM00097	Breast Carcinoma	GDSC	YRINLSVLG	DEG_APCC_DBOX_1	0.1944
p.G117D	SIDM00257	Neuroblastoma	GDSC	YRINLSVLG	DEG_APCC_DBOX_1	0.1944
p.G117D	SIDM00490	Glioma	GDSC	YRINLSVLG	DEG_APCC_DBOX_1	0.1944
p.G117D	SIDM01387	Small Cell Lung Carcinoma	GDSC	YRINLSVLG	DEG_APCC_DBOX_1	0.1944
p.R98C	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	YRINLSVLG	DEG_APCC_DBOX_1	0.1667
p.R98C	ACH-000705	Lung Cancer	CCLE	YRINLSVLG	DEG_APCC_DBOX_1	0.1667
p.R98C	ACH-001113	Lung Cancer	CCLE	YRINLSVLG	DEG_APCC_DBOX_1	0.1667
p.R98C	ACH-002156	Lung Cancer	CCLE	YRINLSVLG	DEG_APCC_DBOX_1	0.1667
p.R98C	LC-1-sq	lung	COSMIC	YRINLSVLG	DEG_APCC_DBOX_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: YRINLSVLG

Degron related mutations and impact score

Drug responses associated with DHX34 mutations

All proteins holding degron of YRINLSVLG

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14147	Probable ATP-dependent RNA helicase DHX34	DEG_APCC_DBOX_1	104:112	YRINLSVLG	APC,CDC20,FZR1	0.8043	More...