DegronMD

Uniprot ID: Q99797

Source protein: Mitochondrial intermediate peptidase

Source gene: MIPEP

Class: DEG_APCC_DBOX_1

Location: 61:69

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9943

ASA_SCORE: 67.0111

COIL: 0.8687

CONS_SCORE: 0.4314

DSS_SCORE: 0.2887

HELIX: 0.0721

FCONS_SCORE: 1.3101

RIG_SCORE: 0.7464

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G67E	TCGA-BA-5556	HNSC	TCGA	ERRGLFGVP	DEG_APCC_DBOX_1	0.6087
p.G67E	DO14232	HNSC	ICGC	ERRGLFGVP	DEG_APCC_DBOX_1	0.6087
p.L65H	TCGA-FI-A2D5	UCEC	TCGA	ERRGLFGVP	DEG_APCC_DBOX_1	0.7313
p.L65H	DO41331	UCEC	ICGC	ERRGLFGVP	DEG_APCC_DBOX_1	0.7313
p.R62C	SIDM00907	Burkitt's Lymphoma	GDSC	ERRGLFGVP	DEG_APCC_DBOX_1	0.8301
p.R62P	SIDM01387	Small Cell Lung Carcinoma	GDSC	ERRGLFGVP	DEG_APCC_DBOX_1	0.7512
p.L58M	ACH-001061	Colon/Colorectal Cancer	CCLE	ERRGLFGVP	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99797	Mitochondrial intermediate peptidase	DEG_APCC_DBOX_1	61:69	ERRGLFGVP	APC,CDC20,FZR1	0.9943	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons