DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
ERRRLATLG
Uniprot ID:
C9J3V5
Source protein:
Testis-expressed protein 22
Source gene:
TEX22
Class:
DEG_APCC_DBOX_1
Location:
70:78
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9688
ASA_SCORE:
71.5667
COIL:
0.3368
CONS_SCORE:
0.6859
DSS_SCORE:
0.4698
HELIX:
0.6264
FCONS_SCORE:
1.3919
RIG_SCORE:
0.7453
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R62L
DO228833
LICA
ICGC
ERRRLATLG
DEG_APCC_DBOX_1
0.1111
p.R80G
DO51153
PRAD
ICGC
ERRRLATLG
DEG_APCC_DBOX_1
0.2778
Drug responses associated with TEX22 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ERRRLATLG
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
C9J3V5
Testis-expressed protein 22
DEG_APCC_DBOX_1
70:78
ERRRLATLG
APC,CDC20,FZR1
0.9688
More...