DegronMD - C9J3V5(TEX22)

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GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E14V	DO9708	COAD	ICGC	RRPPLGLIA	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.1111
p.H21D	DO228061	EOPC	ICGC	RRPPLGLIA	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.3056
p.R62L	DO228833	LICA	ICGC	ERRRLATLG	DEG_APCC_DBOX_1	70:78	Mutation rewiring degron network	0.1111
p.K12N	DO228976	LICA	ICGC	RRPPLGLIA	DEG_APCC_DBOX_1	22:30	Mutation substituting flanking lysine	0.1667
p.S36N	DO229054	LICA	ICGC	RRPPLGLIA	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.1667
p.R23Q	DO48672	LIRI	ICGC	RRPPLGLIA	DEG_APCC_DBOX_1	22:30	Mutation altering degron motif	0.7329
p.R80G	DO51153	PRAD	ICGC	ERRRLATLG	DEG_APCC_DBOX_1	70:78	Mutation rewiring degron network	0.2778
p.P25R	SIDM00710	Small Cell Lung Carcinoma	GDSC	RRPPLGLIA	DEG_APCC_DBOX_1	22:30	Mutation altering degron motif	0.6401
p.P25R	ACH-000394	Lung Cancer	CCLE	RRPPLGLIA	DEG_APCC_DBOX_1	22:30	Mutation altering degron motif	0.6401

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons