DegronMD

Uniprot ID: C9J3V5

Source protein: Testis-expressed protein 22

Source gene: TEX22

Class: DEG_APCC_DBOX_1

Location: 22:30

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9961

ASA_SCORE: 74.1

COIL: 0.8117

CONS_SCORE: 0.5323

DSS_SCORE: 0.5513

HELIX: 0.1529

FCONS_SCORE: 1.2789

RIG_SCORE: 0.7019

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E14V	DO9708	COAD	ICGC	RRPPLGLIA	DEG_APCC_DBOX_1	0.1111
p.H21D	DO228061	EOPC	ICGC	RRPPLGLIA	DEG_APCC_DBOX_1	0.3056
p.K12N	DO228976	LICA	ICGC	RRPPLGLIA	DEG_APCC_DBOX_1	0.1667
p.S36N	DO229054	LICA	ICGC	RRPPLGLIA	DEG_APCC_DBOX_1	0.1667
p.R23Q	DO48672	LIRI	ICGC	RRPPLGLIA	DEG_APCC_DBOX_1	0.7329
p.P25R	SIDM00710	Small Cell Lung Carcinoma	GDSC	RRPPLGLIA	DEG_APCC_DBOX_1	0.6401
p.P25R	ACH-000394	Lung Cancer	CCLE	RRPPLGLIA	DEG_APCC_DBOX_1	0.6401

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
C9J3V5	Testis-expressed protein 22	DEG_APCC_DBOX_1	22:30	RRPPLGLIA	APC,CDC20,FZR1	0.9961	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons