DegronMD

Uniprot ID: P28358

Source protein: Homeobox protein Hox-D10

Source gene: HOXD10

Class: DEG_APCC_DBOX_1

Location: 228:236

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9692

ASA_SCORE: 89.3111

COIL: 0.5723

CONS_SCORE: 0.4677

DSS_SCORE: 0.6045

HELIX: 0.3999

FCONS_SCORE: 1.0107

RIG_SCORE: 0.7134

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P240H	TCGA-46-3769	LUSC	TCGA	ERSCLAEVS	DEG_APCC_DBOX_1	0.2222
p.P240H	DO26590	LUSC	ICGC	ERSCLAEVS	DEG_APCC_DBOX_1	0.2222
p.E228Q	TCGA-50-5930	LUAD	TCGA	ERSCLAEVS	DEG_APCC_DBOX_1	0.5633
p.E228Q	DO25189	LUAD	ICGC	ERSCLAEVS	DEG_APCC_DBOX_1	0.5633
p.E220Q	TCGA-61-1737	OV	TCGA	ERSCLAEVS	DEG_APCC_DBOX_1	0.1111
p.E220Q	DO30620	OV	ICGC	ERSCLAEVS	DEG_APCC_DBOX_1	0.1111
p.L232M	TCGA-77-8128	LUSC	TCGA	ERSCLAEVS	DEG_APCC_DBOX_1	0.711
p.L232M	DO26464	LUSC	ICGC	ERSCLAEVS	DEG_APCC_DBOX_1	0.711
p.E227K	TCGA-AC-A5XS	BRCA	TCGA	ERSCLAEVS	DEG_APCC_DBOX_1	0.3056
p.E227K	TCGA-EO-A3B0	UCEC	TCGA	ERSCLAEVS	DEG_APCC_DBOX_1	0.3056
p.E227K	DO50023	BRCA	ICGC	ERSCLAEVS	DEG_APCC_DBOX_1	0.3056
p.E227K	DO219773	UCEC	ICGC	ERSCLAEVS	DEG_APCC_DBOX_1	0.3056
p.E220K	TCGA-D7-A4YV	STAD	TCGA	ERSCLAEVS	DEG_APCC_DBOX_1	0.1111
p.E220K	TCGA-EA-A1QS	CESC	TCGA	ERSCLAEVS	DEG_APCC_DBOX_1	0.1111
p.E220K	TCGA-N8-A4PP	UCS	TCGA	ERSCLAEVS	DEG_APCC_DBOX_1	0.1111
p.E220K	DO48990	CESC	ICGC	ERSCLAEVS	DEG_APCC_DBOX_1	0.1111
p.E220K	DO47777	STAD	ICGC	ERSCLAEVS	DEG_APCC_DBOX_1	0.1111
p.L225R	TCGA-Y8-A895	KIRP	TCGA	ERSCLAEVS	DEG_APCC_DBOX_1	0.25
p.L225R	DO49801	KIRP	ICGC	ERSCLAEVS	DEG_APCC_DBOX_1	0.25
p.V237M	DO10858	ESAD	ICGC	ERSCLAEVS	DEG_APCC_DBOX_1	0.3056
p.P219L	DO233909	GACA	ICGC	ERSCLAEVS	DEG_APCC_DBOX_1	0.0833
p.E234D	DO228948	LICA	ICGC	ERSCLAEVS	DEG_APCC_DBOX_1	0.5647
p.A221S	DO229035	LICA	ICGC	ERSCLAEVS	DEG_APCC_DBOX_1	0.1389
p.A221T	DO50970	LICA	ICGC	ERSCLAEVS	DEG_APCC_DBOX_1	0.1389
p.S236F	DO220886	MELA	ICGC	ERSCLAEVS	DEG_APCC_DBOX_1	0.6871
p.E228D	SIDM00845	Burkitt's Lymphoma	GDSC	ERSCLAEVS	DEG_APCC_DBOX_1	0.5647
p.E228D	SIDM00035	Thyroid Gland Carcinoma	GDSC	ERSCLAEVS	DEG_APCC_DBOX_1	0.5647
p.E228D	SIDM00461	Acute Myeloid Leukemia	GDSC	ERSCLAEVS	DEG_APCC_DBOX_1	0.5647
p.E228D	SIDM01519	Head and Neck Carcinoma	GDSC	ERSCLAEVS	DEG_APCC_DBOX_1	0.5647
p.E228D	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	ERSCLAEVS	DEG_APCC_DBOX_1	0.5647
p.E228D	S-117	soft_tissue	COSMIC	ERSCLAEVS	DEG_APCC_DBOX_1	0.5647
p.E228D	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	ERSCLAEVS	DEG_APCC_DBOX_1	0.5647
p.A233T	SIDM00680	Colorectal Carcinoma	GDSC	ERSCLAEVS	DEG_APCC_DBOX_1	0.6028
p.A233T	ACH-000957	Colon/Colorectal Cancer	CCLE	ERSCLAEVS	DEG_APCC_DBOX_1	0.6028
p.A233T	LS-180	large_intestine	COSMIC	ERSCLAEVS	DEG_APCC_DBOX_1	0.6028
p.L232P	ACH-000860	Lung Cancer	CCLE	ERSCLAEVS	DEG_APCC_DBOX_1	0.7582

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ERSCLAEVS

Degron related mutations and impact score

Drug responses associated with HOXD10 mutations

All proteins holding degron of ERSCLAEVS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28358	Homeobox protein Hox-D10	DEG_APCC_DBOX_1	228:236	ERSCLAEVS	APC,CDC20,FZR1	0.9692	More...