DegronMD - P28358(HOXD10)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D307G	TCGA-06-5416	GBM	TCGA	RRMKLKKMS	DEG_APCC_DBOX_1	317:325	Mutation rewiring degron network	0.0556
p.D307G	DO10880	GBM	ICGC	RRMKLKKMS	DEG_APCC_DBOX_1	317:325	Mutation rewiring degron network	0.0556
p.P240H	TCGA-46-3769	LUSC	TCGA	ERSCLAEVS	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.2222
p.P240H	DO26590	LUSC	ICGC	ERSCLAEVS	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.2222
p.E228Q	TCGA-50-5930	LUAD	TCGA	ERSCLAEVS	DEG_APCC_DBOX_1	228:236	Mutation altering degron motif	0.5633
p.E228Q	DO25189	LUAD	ICGC	ERSCLAEVS	DEG_APCC_DBOX_1	228:236	Mutation altering degron motif	0.5633
p.R308K	TCGA-55-7570	LUAD	TCGA	RRMKLKKMS	DEG_APCC_DBOX_1	317:325	Mutation rewiring degron network	0.0833
p.R308K	DO25280	LUAD	ICGC	RRMKLKKMS	DEG_APCC_DBOX_1	317:325	Mutation rewiring degron network	0.0833
p.E220Q	TCGA-61-1737	OV	TCGA	ERSCLAEVS	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.1111
p.E220Q	DO30620	OV	ICGC	ERSCLAEVS	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.1111
p.L232M	TCGA-77-8128	LUSC	TCGA	ERSCLAEVS	DEG_APCC_DBOX_1	228:236	Mutation altering degron motif	0.711
p.L232M	DO26464	LUSC	ICGC	ERSCLAEVS	DEG_APCC_DBOX_1	228:236	Mutation altering degron motif	0.711
p.A335T	TCGA-96-7544	LUSC	TCGA	RRMKLKKMS	DEG_APCC_DBOX_1	317:325	Mutation rewiring degron network	0.0556
p.A335T	TCGA-KK-A59V	PRAD	TCGA	RRMKLKKMS	DEG_APCC_DBOX_1	317:325	Mutation rewiring degron network	0.0556
p.A335T	DO26425	LUSC	ICGC	RRMKLKKMS	DEG_APCC_DBOX_1	317:325	Mutation rewiring degron network	0.0556
p.A335T	DO51346	PRAD	ICGC	RRMKLKKMS	DEG_APCC_DBOX_1	317:325	Mutation rewiring degron network	0.0556
p.E227K	TCGA-AC-A5XS	BRCA	TCGA	ERSCLAEVS	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.3056
p.E227K	TCGA-EO-A3B0	UCEC	TCGA	ERSCLAEVS	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.3056
p.E227K	DO50023	BRCA	ICGC	ERSCLAEVS	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.3056
p.E227K	DO219773	UCEC	ICGC	ERSCLAEVS	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.3056
p.S325G	TCGA-AX-A1CE	UCEC	TCGA	RRMKLKKMS	DEG_APCC_DBOX_1	317:325	Mutation altering degron motif	0.5882
p.S325G	DO42280	UCEC	ICGC	RRMKLKKMS	DEG_APCC_DBOX_1	317:325	Mutation altering degron motif	0.5882
p.R326P	TCGA-BB-4223	HNSC	TCGA	RRMKLKKMS	DEG_APCC_DBOX_1	317:325	Mutation rewiring degron network	0.3056
p.R326P	DO15607	HNSC	ICGC	RRMKLKKMS	DEG_APCC_DBOX_1	317:325	Mutation rewiring degron network	0.3056
p.N328S	TCGA-D3-A1QA	SKCM	TCGA	RRMKLKKMS	DEG_APCC_DBOX_1	317:325	Mutation rewiring degron network	0.25
p.N328S	DO47469	SKCM	ICGC	RRMKLKKMS	DEG_APCC_DBOX_1	317:325	Mutation rewiring degron network	0.25
p.E220K	TCGA-D7-A4YV	STAD	TCGA	ERSCLAEVS	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.1111
p.E220K	TCGA-EA-A1QS	CESC	TCGA	ERSCLAEVS	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.1111
p.E220K	TCGA-N8-A4PP	UCS	TCGA	ERSCLAEVS	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.1111
p.E220K	DO48990	CESC	ICGC	ERSCLAEVS	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.1111
p.E220K	DO47777	STAD	ICGC	ERSCLAEVS	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.1111
p.S325N	TCGA-EO-A22R	UCEC	TCGA	RRMKLKKMS	DEG_APCC_DBOX_1	317:325	Mutation altering degron motif	0.5958
p.S325N	DO42713	UCEC	ICGC	RRMKLKKMS	DEG_APCC_DBOX_1	317:325	Mutation altering degron motif	0.5958
p.R331L	TCGA-ER-A1A1	SKCM	TCGA	RRMKLKKMS	DEG_APCC_DBOX_1	317:325	Mutation rewiring degron network	0.1667
p.R331L	DO37413	SKCM	ICGC	RRMKLKKMS	DEG_APCC_DBOX_1	317:325	Mutation rewiring degron network	0.1667
p.M324I	TCGA-XF-A9SP	BLCA	TCGA	RRMKLKKMS	DEG_APCC_DBOX_1	317:325	Mutation altering degron motif	0.6507
p.M324I	DO223598	BLCA	ICGC	RRMKLKKMS	DEG_APCC_DBOX_1	317:325	Mutation altering degron motif	0.6507
p.L225R	TCGA-Y8-A895	KIRP	TCGA	ERSCLAEVS	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.25
p.L225R	DO49801	KIRP	ICGC	ERSCLAEVS	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.25
p.V237M	DO10858	ESAD	ICGC	ERSCLAEVS	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.3056
p.P219L	DO233909	GACA	ICGC	ERSCLAEVS	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.0833
p.E234D	DO228948	LICA	ICGC	ERSCLAEVS	DEG_APCC_DBOX_1	228:236	Mutation altering degron motif	0.5647
p.A221S	DO229035	LICA	ICGC	ERSCLAEVS	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.1389
p.R317H	DO50970	LICA	ICGC	RRMKLKKMS	DEG_APCC_DBOX_1	317:325	Mutation altering degron motif	0.7133
p.A221T	DO50970	LICA	ICGC	ERSCLAEVS	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.1389
p.S236F	DO220886	MELA	ICGC	ERSCLAEVS	DEG_APCC_DBOX_1	228:236	Mutation altering degron motif	0.6871
p.V310F	DO27887	ORCA	ICGC	RRMKLKKMS	DEG_APCC_DBOX_1	317:325	Mutation rewiring degron network	0.1389
p.K311N	DO229462	SKCA	ICGC	RRMKLKKMS	DEG_APCC_DBOX_1	317:325	Mutation substituting flanking lysine	0.2778
p.E228D	SIDM00845	Burkitt's Lymphoma	GDSC	ERSCLAEVS	DEG_APCC_DBOX_1	228:236	Mutation altering degron motif	0.5647
p.E228D	SIDM00035	Thyroid Gland Carcinoma	GDSC	ERSCLAEVS	DEG_APCC_DBOX_1	228:236	Mutation altering degron motif	0.5647
p.E228D	SIDM00461	Acute Myeloid Leukemia	GDSC	ERSCLAEVS	DEG_APCC_DBOX_1	228:236	Mutation altering degron motif	0.5647
p.E228D	SIDM01519	Head and Neck Carcinoma	GDSC	ERSCLAEVS	DEG_APCC_DBOX_1	228:236	Mutation altering degron motif	0.5647
p.E228D	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	ERSCLAEVS	DEG_APCC_DBOX_1	228:236	Mutation altering degron motif	0.5647
p.E228D	S-117	soft tissue	COSMIC	ERSCLAEVS	DEG_APCC_DBOX_1	228:236	Mutation altering degron motif	0.5647
p.E228D	Daudi	haematopoietic and lymphoid tissue	COSMIC	ERSCLAEVS	DEG_APCC_DBOX_1	228:236	Mutation altering degron motif	0.5647
p.A233T	SIDM00680	Colorectal Carcinoma	GDSC	ERSCLAEVS	DEG_APCC_DBOX_1	228:236	Mutation altering degron motif	0.6028
p.A233T	ACH-000957	Colon/Colorectal Cancer	CCLE	ERSCLAEVS	DEG_APCC_DBOX_1	228:236	Mutation altering degron motif	0.6028
p.A233T	LS-180	large intestine	COSMIC	ERSCLAEVS	DEG_APCC_DBOX_1	228:236	Mutation altering degron motif	0.6028
p.L232P	ACH-000860	Lung Cancer	CCLE	ERSCLAEVS	DEG_APCC_DBOX_1	228:236	Mutation altering degron motif	0.7582

Kaplan plot for HOXD10 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HOXD10

UniProt ID: P28358

Entrez ID: 3236

Protein name: Homeobox protein Hox-D10 (Homeobox protein Hox-4D) (Homeobox protein Hox-4E)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HOXD10 in