DegronMD

Uniprot ID: P28358

Source protein: Homeobox protein Hox-D10

Source gene: HOXD10

Class: DEG_APCC_DBOX_1

Location: 317:325

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5957

ASA_SCORE: 111.0556

COIL: 0.5459

CONS_SCORE: 0.8898

DSS_SCORE: 0.3

HELIX: 0.3888

FCONS_SCORE: 1.1505

RIG_SCORE: 0.826

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D307G	TCGA-06-5416	GBM	TCGA	RRMKLKKMS	DEG_APCC_DBOX_1	0.0556
p.D307G	DO10880	GBM	ICGC	RRMKLKKMS	DEG_APCC_DBOX_1	0.0556
p.R308K	TCGA-55-7570	LUAD	TCGA	RRMKLKKMS	DEG_APCC_DBOX_1	0.0833
p.R308K	DO25280	LUAD	ICGC	RRMKLKKMS	DEG_APCC_DBOX_1	0.0833
p.A335T	TCGA-96-7544	LUSC	TCGA	RRMKLKKMS	DEG_APCC_DBOX_1	0.0556
p.A335T	TCGA-KK-A59V	PRAD	TCGA	RRMKLKKMS	DEG_APCC_DBOX_1	0.0556
p.A335T	DO26425	LUSC	ICGC	RRMKLKKMS	DEG_APCC_DBOX_1	0.0556
p.A335T	DO51346	PRAD	ICGC	RRMKLKKMS	DEG_APCC_DBOX_1	0.0556
p.S325G	TCGA-AX-A1CE	UCEC	TCGA	RRMKLKKMS	DEG_APCC_DBOX_1	0.5882
p.S325G	DO42280	UCEC	ICGC	RRMKLKKMS	DEG_APCC_DBOX_1	0.5882
p.R326P	TCGA-BB-4223	HNSC	TCGA	RRMKLKKMS	DEG_APCC_DBOX_1	0.3056
p.R326P	DO15607	HNSC	ICGC	RRMKLKKMS	DEG_APCC_DBOX_1	0.3056
p.N328S	TCGA-D3-A1QA	SKCM	TCGA	RRMKLKKMS	DEG_APCC_DBOX_1	0.25
p.N328S	DO47469	SKCM	ICGC	RRMKLKKMS	DEG_APCC_DBOX_1	0.25
p.S325N	TCGA-EO-A22R	UCEC	TCGA	RRMKLKKMS	DEG_APCC_DBOX_1	0.5958
p.S325N	DO42713	UCEC	ICGC	RRMKLKKMS	DEG_APCC_DBOX_1	0.5958
p.R331L	TCGA-ER-A1A1	SKCM	TCGA	RRMKLKKMS	DEG_APCC_DBOX_1	0.1667
p.R331L	DO37413	SKCM	ICGC	RRMKLKKMS	DEG_APCC_DBOX_1	0.1667
p.M324I	TCGA-XF-A9SP	BLCA	TCGA	RRMKLKKMS	DEG_APCC_DBOX_1	0.6507
p.M324I	DO223598	BLCA	ICGC	RRMKLKKMS	DEG_APCC_DBOX_1	0.6507
p.R317H	DO50970	LICA	ICGC	RRMKLKKMS	DEG_APCC_DBOX_1	0.7133
p.V310F	DO27887	ORCA	ICGC	RRMKLKKMS	DEG_APCC_DBOX_1	0.1389
p.K311N	DO229462	SKCA	ICGC	RRMKLKKMS	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28358	Homeobox protein Hox-D10	DEG_APCC_DBOX_1	317:325	RRMKLKKMS	APC,CDC20,FZR1	0.5957	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons