DegronMD

Uniprot ID: Q96MK2

Source protein: RIPOR family member 3

Source gene: RIPOR3

Class: DEG_APCC_DBOX_1

Location: 354:362

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8325

ASA_SCORE: 91.6778

COIL: 0.437

CONS_SCORE: 0.3485

DSS_SCORE: 0.3584

HELIX: 0.5102

FCONS_SCORE: 1.4516

RIG_SCORE: 0.8545

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P347L	SIDM01953	Colorectal Carcinoma	GDSC	ERYYLSVLQ	DEG_APCC_DBOX_1	0.1389
p.P347S	SIDM00267	Biliary Tract Carcinoma	GDSC	ERYYLSVLQ	DEG_APCC_DBOX_1	0.1389
p.P347S	SIDM00302	Other Solid Cancers	GDSC	ERYYLSVLQ	DEG_APCC_DBOX_1	0.1389
p.P347S	TGBC24TKB	biliary_tract	COSMIC	ERYYLSVLQ	DEG_APCC_DBOX_1	0.1389
p.P347S	KGN	ovary	COSMIC	ERYYLSVLQ	DEG_APCC_DBOX_1	0.1389
p.Y356C	SIDM01659	Kidney Carcinoma	GDSC	ERYYLSVLQ	DEG_APCC_DBOX_1	0.5976

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96MK2	RIPOR family member 3	DEG_APCC_DBOX_1	354:362	ERYYLSVLQ	APC,CDC20,FZR1	0.8325	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons