DegronMD

Uniprot ID: Q8N5U6

Source protein: RING finger protein 10

Source gene: RNF10

Class: DEG_COP1_1

Location: 749:761

E3 ligase: COP1

DEGRON score: 0.9728

ASA_SCORE: 76.2

COIL: 0.8536

CONS_SCORE: 0.2627

DSS_SCORE: 0.6716

HELIX: 0.1145

FCONS_SCORE: 0.9901

RIG_SCORE: 0.6478

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R760H	SIDM01966	Colorectal Carcinoma	GDSC	ESDNSDRVPVPSF	DEG_COP1_1	0.8244
p.R760H	SIDM00214	Colorectal Carcinoma	GDSC	ESDNSDRVPVPSF	DEG_COP1_1	0.8244
p.R760H	SNU-407	large_intestine	COSMIC	ESDNSDRVPVPSF	DEG_COP1_1	0.8244
p.R755L	DO229026	LICA	ICGC	ESDNSDRVPVPSF	DEG_COP1_1	0.7316
p.R755L	DO229045	LICA	ICGC	ESDNSDRVPVPSF	DEG_COP1_1	0.7316
p.E749G	TCGA-A8-A06Z	BRCA	TCGA	ESDNSDRVPVPSF	DEG_COP1_1	0.7199
p.E749G	DO4092	BRCA	ICGC	ESDNSDRVPVPSF	DEG_COP1_1	0.7199
p.R755C	TCGA-2Z-A9JI	KIRP	TCGA	ESDNSDRVPVPSF	DEG_COP1_1	0.719
p.R755C	DO219669	KIRP	ICGC	ESDNSDRVPVPSF	DEG_COP1_1	0.719
p.R755H	ACH-000955	Colon/Colorectal Cancer	CCLE	ESDNSDRVPVPSF	DEG_COP1_1	0.7133
p.R755H	SNU-407	large_intestine	COSMIC	ESDNSDRVPVPSF	DEG_COP1_1	0.7133
p.P757H	TCGA-AP-A059	UCEC	TCGA	ESDNSDRVPVPSF	DEG_COP1_1	0.6583
p.P757H	DO41361	UCEC	ICGC	ESDNSDRVPVPSF	DEG_COP1_1	0.6583
p.N752Y	TCGA-DD-A115	LIHC	TCGA	ESDNSDRVPVPSF	DEG_COP1_1	0.5948
p.N752Y	DO22911	LIHC	ICGC	ESDNSDRVPVPSF	DEG_COP1_1	0.5948
p.D751E	TCGA-57-1994	OV	TCGA	ESDNSDRVPVPSF	DEG_COP1_1	0.5647
p.D751E	DO30510	OV	ICGC	ESDNSDRVPVPSF	DEG_COP1_1	0.5647
p.P748S	SIDM00129	Melanoma	GDSC	ESDNSDRVPVPSF	DEG_COP1_1	0.3056
p.D747N	DO234462	ESAD	ICGC	ESDNSDRVPVPSF	DEG_COP1_1	0.2778
p.S764F	TCGA-AA-3510	COAD	TCGA	ESDNSDRVPVPSF	DEG_COP1_1	0.25
p.S764F	DO7783	COAD	ICGC	ESDNSDRVPVPSF	DEG_COP1_1	0.25
p.S764P	TCGA-BP-5176	KIRC	TCGA	ESDNSDRVPVPSF	DEG_COP1_1	0.25
p.S764P	DO16658	KIRC	ICGC	ESDNSDRVPVPSF	DEG_COP1_1	0.25
p.S746G	TCGA-BR-4267	STAD	TCGA	ESDNSDRVPVPSF	DEG_COP1_1	0.25
p.S746G	DO38316	STAD	ICGC	ESDNSDRVPVPSF	DEG_COP1_1	0.25

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N5U6	RING finger protein 10	DEG_COP1_1	749:761	ESDNSDRVPVPSF	COP1	0.9728	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons