DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
ESDNSDRVPVPSF
Uniprot ID:
Q8N5U6
Source protein:
RING finger protein 10
Source gene:
RNF10
Class:
DEG_COP1_1
Location:
749:761
E3 ligase:
COP1
DEGRON score:
0.9728
ASA_SCORE:
76.2
COIL:
0.8536
CONS_SCORE:
0.2627
DSS_SCORE:
0.6716
HELIX:
0.1145
FCONS_SCORE:
0.9901
RIG_SCORE:
0.6478
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R755C
TCGA-2Z-A9JI
KIRP
TCGA
ESDNSDRVPVPSF
DEG_COP1_1
0.719
p.R755C
DO219669
KIRP
ICGC
ESDNSDRVPVPSF
DEG_COP1_1
0.719
p.D751E
TCGA-57-1994
OV
TCGA
ESDNSDRVPVPSF
DEG_COP1_1
0.5647
p.D751E
DO30510
OV
ICGC
ESDNSDRVPVPSF
DEG_COP1_1
0.5647
p.E749G
TCGA-A8-A06Z
BRCA
TCGA
ESDNSDRVPVPSF
DEG_COP1_1
0.7199
p.E749G
DO4092
BRCA
ICGC
ESDNSDRVPVPSF
DEG_COP1_1
0.7199
p.S764F
TCGA-AA-3510
COAD
TCGA
ESDNSDRVPVPSF
DEG_COP1_1
0.25
p.S764F
DO7783
COAD
ICGC
ESDNSDRVPVPSF
DEG_COP1_1
0.25
p.P757H
TCGA-AP-A059
UCEC
TCGA
ESDNSDRVPVPSF
DEG_COP1_1
0.6583
p.P757H
DO41361
UCEC
ICGC
ESDNSDRVPVPSF
DEG_COP1_1
0.6583
p.S764P
TCGA-BP-5176
KIRC
TCGA
ESDNSDRVPVPSF
DEG_COP1_1
0.25
p.S764P
DO16658
KIRC
ICGC
ESDNSDRVPVPSF
DEG_COP1_1
0.25
p.S746G
TCGA-BR-4267
STAD
TCGA
ESDNSDRVPVPSF
DEG_COP1_1
0.25
p.S746G
DO38316
STAD
ICGC
ESDNSDRVPVPSF
DEG_COP1_1
0.25
p.N752Y
TCGA-DD-A115
LIHC
TCGA
ESDNSDRVPVPSF
DEG_COP1_1
0.5948
p.N752Y
DO22911
LIHC
ICGC
ESDNSDRVPVPSF
DEG_COP1_1
0.5948
p.D747N
DO234462
ESAD
ICGC
ESDNSDRVPVPSF
DEG_COP1_1
0.2778
p.S766I
DO228971
LICA
ICGC
ESDNSDRVPVPSF
DEG_COP1_1
0.1944
p.R755L
DO229026
LICA
ICGC
ESDNSDRVPVPSF
DEG_COP1_1
0.7316
p.R755L
DO229045
LICA
ICGC
ESDNSDRVPVPSF
DEG_COP1_1
0.7316
p.R760H
SIDM01966
Colorectal Carcinoma
GDSC
ESDNSDRVPVPSF
DEG_COP1_1
0.8244
p.R760H
SIDM00214
Colorectal Carcinoma
GDSC
ESDNSDRVPVPSF
DEG_COP1_1
0.8244
p.R760H
SNU-407
large_intestine
COSMIC
ESDNSDRVPVPSF
DEG_COP1_1
0.8244
p.P748S
SIDM00129
Melanoma
GDSC
ESDNSDRVPVPSF
DEG_COP1_1
0.3056
p.R755H
ACH-000955
Colon/Colorectal Cancer
CCLE
ESDNSDRVPVPSF
DEG_COP1_1
0.7133
p.R755H
SNU-407
large_intestine
COSMIC
ESDNSDRVPVPSF
DEG_COP1_1
0.7133
p.P743S
ACH-002121
Skin Cancer
CCLE
ESDNSDRVPVPSF
DEG_COP1_1
0.1667
Drug responses associated with RNF10 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ESDNSDRVPVPSF
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8N5U6
RING finger protein 10
DEG_COP1_1
749:761
ESDNSDRVPVPSF
COP1
0.9728
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