DegronMD - Q8N5U6(RNF10)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R755C	TCGA-2Z-A9JI	KIRP	TCGA	ESDNSDRVPVPSF	DEG_COP1_1	749:761	Mutation altering degron motif	0.719
p.R755C	DO219669	KIRP	ICGC	ESDNSDRVPVPSF	DEG_COP1_1	749:761	Mutation altering degron motif	0.719
p.D751E	TCGA-57-1994	OV	TCGA	ESDNSDRVPVPSF	DEG_COP1_1	749:761	Mutation altering degron motif	0.5647
p.D751E	DO30510	OV	ICGC	ESDNSDRVPVPSF	DEG_COP1_1	749:761	Mutation altering degron motif	0.5647
p.S786F	TCGA-95-7944	LUAD	TCGA	LDTPATS	DEG_SCF_FBW7_1	776:782	Mutation blocking phosphorylation signal	0.6667
p.S786F	DO25163	LUAD	ICGC	LDTPATS	DEG_SCF_FBW7_1	776:782	Mutation blocking phosphorylation signal	0.6667
p.E749G	TCGA-A8-A06Z	BRCA	TCGA	ESDNSDRVPVPSF	DEG_COP1_1	749:761	Mutation altering degron motif	0.7199
p.E749G	DO4092	BRCA	ICGC	ESDNSDRVPVPSF	DEG_COP1_1	749:761	Mutation altering degron motif	0.7199
p.S764F	TCGA-AA-3510	COAD	TCGA	ESDNSDRVPVPSF	DEG_COP1_1	749:761	Mutation rewiring degron network	0.25
p.S764F	DO7783	COAD	ICGC	ESDNSDRVPVPSF	DEG_COP1_1	749:761	Mutation rewiring degron network	0.25
p.P757H	TCGA-AP-A059	UCEC	TCGA	ESDNSDRVPVPSF	DEG_COP1_1	749:761	Mutation altering degron motif	0.6583
p.P757H	DO41361	UCEC	ICGC	ESDNSDRVPVPSF	DEG_COP1_1	749:761	Mutation altering degron motif	0.6583
p.A780T	TCGA-AX-A3FT	UCEC	TCGA	LDTPATS	DEG_SCF_FBW7_1	776:782	Mutation altering degron motif	0.6028
p.A780T	DO40801	UCEC	ICGC	LDTPATS	DEG_SCF_FBW7_1	776:782	Mutation altering degron motif	0.6028
p.A780T	ACH-000998	Colon/Colorectal Cancer	CCLE	LDTPATS	DEG_SCF_FBW7_1	776:782	Mutation altering degron motif	0.6028
p.A780T	CW-2	large intestine	COSMIC	LDTPATS	DEG_SCF_FBW7_1	776:782	Mutation altering degron motif	0.6028
p.S764P	TCGA-BP-5176	KIRC	TCGA	ESDNSDRVPVPSF	DEG_COP1_1	749:761	Mutation rewiring degron network	0.25
p.S764P	DO16658	KIRC	ICGC	ESDNSDRVPVPSF	DEG_COP1_1	749:761	Mutation rewiring degron network	0.25
p.S746G	TCGA-BR-4267	STAD	TCGA	ESDNSDRVPVPSF	DEG_COP1_1	749:761	Mutation rewiring degron network	0.25
p.S746G	DO38316	STAD	ICGC	ESDNSDRVPVPSF	DEG_COP1_1	749:761	Mutation rewiring degron network	0.25
p.N752Y	TCGA-DD-A115	LIHC	TCGA	ESDNSDRVPVPSF	DEG_COP1_1	749:761	Mutation altering degron motif	0.5948
p.N752Y	DO22911	LIHC	ICGC	ESDNSDRVPVPSF	DEG_COP1_1	749:761	Mutation altering degron motif	0.5948
p.S786C	TCGA-ZB-A96V	THYM	TCGA	LDTPATS	DEG_SCF_FBW7_1	776:782	Mutation blocking phosphorylation signal	0.6667
p.D747N	DO234462	ESAD	ICGC	ESDNSDRVPVPSF	DEG_COP1_1	749:761	Mutation rewiring degron network	0.2778
p.S766I	DO228971	LICA	ICGC	ESDNSDRVPVPSF	DEG_COP1_1	749:761	Mutation rewiring degron network	0.1944
p.S766I	DO228971	LICA	ICGC	LDTPATS	DEG_SCF_FBW7_1	776:782	Mutation rewiring degron network	0.0556
p.R755L	DO229026	LICA	ICGC	ESDNSDRVPVPSF	DEG_COP1_1	749:761	Mutation altering degron motif	0.7316
p.R755L	DO229045	LICA	ICGC	ESDNSDRVPVPSF	DEG_COP1_1	749:761	Mutation altering degron motif	0.7316
p.R760H	SIDM01966	Colorectal Carcinoma	GDSC	ESDNSDRVPVPSF	DEG_COP1_1	749:761	Mutation altering degron motif	0.8244
p.R760H	SIDM00214	Colorectal Carcinoma	GDSC	ESDNSDRVPVPSF	DEG_COP1_1	749:761	Mutation altering degron motif	0.8244
p.R760H	SNU-407	large intestine	COSMIC	ESDNSDRVPVPSF	DEG_COP1_1	749:761	Mutation altering degron motif	0.8244
p.I774L	SIDM00773	Non-Cancerous	GDSC	LDTPATS	DEG_SCF_FBW7_1	776:782	Mutation rewiring degron network	0.2778
p.I774L	SIDM00774	Breast Carcinoma	GDSC	LDTPATS	DEG_SCF_FBW7_1	776:782	Mutation rewiring degron network	0.2778
p.P748S	SIDM00129	Melanoma	GDSC	ESDNSDRVPVPSF	DEG_COP1_1	749:761	Mutation rewiring degron network	0.3056
p.A785T	SIDM00282	Colorectal Carcinoma	GDSC	LDTPATS	DEG_SCF_FBW7_1	776:782	Mutation rewiring degron network	0.25
p.A785T	CW-2	large intestine	COSMIC	LDTPATS	DEG_SCF_FBW7_1	776:782	Mutation rewiring degron network	0.25
p.L790P	SIDM00282	Colorectal Carcinoma	GDSC	LDTPATS	DEG_SCF_FBW7_1	776:782	Mutation rewiring degron network	0.1111
p.L790P	CW-2	large intestine	COSMIC	LDTPATS	DEG_SCF_FBW7_1	776:782	Mutation rewiring degron network	0.1111
p.R755H	ACH-000955	Colon/Colorectal Cancer	CCLE	ESDNSDRVPVPSF	DEG_COP1_1	749:761	Mutation altering degron motif	0.7133
p.R755H	SNU-407	large intestine	COSMIC	ESDNSDRVPVPSF	DEG_COP1_1	749:761	Mutation altering degron motif	0.7133
p.L785P	ACH-000998	Colon/Colorectal Cancer	CCLE	LDTPATS	DEG_SCF_FBW7_1	776:782	Mutation rewiring degron network	0.25
p.L785P	CW-2	large intestine	COSMIC	LDTPATS	DEG_SCF_FBW7_1	776:782	Mutation rewiring degron network	0.25
p.P743S	ACH-002121	Skin Cancer	CCLE	ESDNSDRVPVPSF	DEG_COP1_1	749:761	Mutation rewiring degron network	0.1667

Kaplan plot for RNF10 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RNF10

UniProt ID: Q8N5U6

Entrez ID: 9921

Protein name: RING finger protein 10

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RNF10 in