DegronMD

Uniprot ID: Q8N5U6

Source protein: RING finger protein 10

Source gene: RNF10

Class: DEG_SCF_FBW7_1

Location: 776:782

E3 ligase: FBXW7

DEGRON score: 0.9662

ASA_SCORE: 83.5143

COIL: 0.9051

CONS_SCORE: 0.2371

DSS_SCORE: 0.5493

HELIX: 0.0714

FCONS_SCORE: 0.8267

RIG_SCORE: 0.7004

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S786F	TCGA-95-7944	LUAD	TCGA	LDTPATS	DEG_SCF_FBW7_1	0.6667
p.S786F	DO25163	LUAD	ICGC	LDTPATS	DEG_SCF_FBW7_1	0.6667
p.A780T	TCGA-AX-A3FT	UCEC	TCGA	LDTPATS	DEG_SCF_FBW7_1	0.6028
p.A780T	DO40801	UCEC	ICGC	LDTPATS	DEG_SCF_FBW7_1	0.6028
p.A780T	ACH-000998	Colon/Colorectal Cancer	CCLE	LDTPATS	DEG_SCF_FBW7_1	0.6028
p.A780T	CW-2	large_intestine	COSMIC	LDTPATS	DEG_SCF_FBW7_1	0.6028
p.S786C	TCGA-ZB-A96V	THYM	TCGA	LDTPATS	DEG_SCF_FBW7_1	0.6667
p.S766I	DO228971	LICA	ICGC	LDTPATS	DEG_SCF_FBW7_1	0.0556
p.I774L	SIDM00773	Non-Cancerous	GDSC	LDTPATS	DEG_SCF_FBW7_1	0.2778
p.I774L	SIDM00774	Breast Carcinoma	GDSC	LDTPATS	DEG_SCF_FBW7_1	0.2778
p.A785T	SIDM00282	Colorectal Carcinoma	GDSC	LDTPATS	DEG_SCF_FBW7_1	0.25
p.A785T	CW-2	large_intestine	COSMIC	LDTPATS	DEG_SCF_FBW7_1	0.25
p.L790P	SIDM00282	Colorectal Carcinoma	GDSC	LDTPATS	DEG_SCF_FBW7_1	0.1111
p.L790P	CW-2	large_intestine	COSMIC	LDTPATS	DEG_SCF_FBW7_1	0.1111
p.L785P	ACH-000998	Colon/Colorectal Cancer	CCLE	LDTPATS	DEG_SCF_FBW7_1	0.25
p.L785P	CW-2	large_intestine	COSMIC	LDTPATS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N5U6	RING finger protein 10	DEG_SCF_FBW7_1	776:782	LDTPATS	FBXW7	0.9662	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons