DegronMD

Uniprot ID: P13727

Source protein: Bone marrow proteoglycan

Source gene: PRG2

Class: DEG_COP1_1

Location: 75:82

E3 ligase: COP1

DEGRON score: 0.8681

ASA_SCORE: 84.9125

COIL: 0.7653

CONS_SCORE: 0.4098

DSS_SCORE: 0.4985

HELIX: 0.0338

FCONS_SCORE: 0.9593

RIG_SCORE: 0.7482

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V74A	TCGA-29-1691	OV	TCGA	ESISVPDM	DEG_COP1_1	0.3056
p.V74A	DO32133	OV	ICGC	ESISVPDM	DEG_COP1_1	0.3056
p.E75K	TCGA-AO-A03M	BRCA	TCGA	ESISVPDM	DEG_COP1_1	0.7022
p.E75K	DO2216	BRCA	ICGC	ESISVPDM	DEG_COP1_1	0.7022
p.V83M	TCGA-AP-A1DK	UCEC	TCGA	ESISVPDM	DEG_COP1_1	0.3056
p.V83M	DO42033	UCEC	ICGC	ESISVPDM	DEG_COP1_1	0.3056
p.D71Y	TCGA-AX-A05Z	UCEC	TCGA	ESISVPDM	DEG_COP1_1	0.2222
p.D71Y	DO40884	UCEC	ICGC	ESISVPDM	DEG_COP1_1	0.2222
p.S78L	TCGA-EE-A2MJ	SKCM	TCGA	ESISVPDM	DEG_COP1_1	0.6556
p.S78L	DO38099	SKCM	ICGC	ESISVPDM	DEG_COP1_1	0.6556
p.P90S	TCGA-LP-A5U2	CESC	TCGA	ESISVPDM	DEG_COP1_1	0.1111
p.P90S	DO51610	CESC	ICGC	ESISVPDM	DEG_COP1_1	0.1111
p.G72E	TCGA-OD-A75X	SKCM	TCGA	ESISVPDM	DEG_COP1_1	0.25
p.G72E	DO48601	SKCM	ICGC	ESISVPDM	DEG_COP1_1	0.25
p.I77V	DO44832	LICA	ICGC	ESISVPDM	DEG_COP1_1	0.5965
p.E75V	DO228298	MALY	ICGC	ESISVPDM	DEG_COP1_1	0.7693
p.L87R	SIDM01312	Esophageal Carcinoma	GDSC	ESISVPDM	DEG_COP1_1	0.1944
p.P80S	SIDM01007	T-Lymphoblastic Leukemia	GDSC	ESISVPDM	DEG_COP1_1	0.6752
p.P80S	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	ESISVPDM	DEG_COP1_1	0.6752
p.G72R	SIDM00149	Melanoma	GDSC	ESISVPDM	DEG_COP1_1	0.25
p.G72R	LOXIMVI	skin	COSMIC	ESISVPDM	DEG_COP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13727	Bone marrow proteoglycan	DEG_COP1_1	75:82	ESISVPDM	COP1	0.8681	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons