DegronMD - P13727(PRG2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G63V	TCGA-17-Z030	LUAD	TCGA	MEETPCRE	DEG_SCF_FBW7_2	46:53	Mutation rewiring degron network	0.0556
p.V74A	TCGA-29-1691	OV	TCGA	ESISVPDM	DEG_COP1_1	75:82	Mutation rewiring degron network	0.3056
p.V74A	DO32133	OV	ICGC	ESISVPDM	DEG_COP1_1	75:82	Mutation rewiring degron network	0.3056
p.E47D	TCGA-55-7724	LUAD	TCGA	MEETPCRE	DEG_SCF_FBW7_2	46:53	Mutation altering degron motif	0.5647
p.E47D	DO45373	LUAD	ICGC	MEETPCRE	DEG_SCF_FBW7_2	46:53	Mutation altering degron motif	0.5647
p.E39D	TCGA-A1-A0SK	BRCA	TCGA	MEETPCRE	DEG_SCF_FBW7_2	46:53	Mutation rewiring degron network	0.1389
p.E39D	DO4143	BRCA	ICGC	MEETPCRE	DEG_SCF_FBW7_2	46:53	Mutation rewiring degron network	0.1389
p.G61C	TCGA-A5-A0G1	UCEC	TCGA	MEETPCRE	DEG_SCF_FBW7_2	46:53	Mutation rewiring degron network	0.1111
p.G61C	DO42472	UCEC	ICGC	MEETPCRE	DEG_SCF_FBW7_2	46:53	Mutation rewiring degron network	0.1111
p.E37D	TCGA-AA-3664	COAD	TCGA	MEETPCRE	DEG_SCF_FBW7_2	46:53	Mutation rewiring degron network	0.0833
p.E37D	DO7831	COAD	ICGC	MEETPCRE	DEG_SCF_FBW7_2	46:53	Mutation rewiring degron network	0.0833
p.E43D	TCGA-AA-A010	COAD	TCGA	MEETPCRE	DEG_SCF_FBW7_2	46:53	Mutation rewiring degron network	0.25
p.E53K	TCGA-AG-A002	READ	TCGA	MEETPCRE	DEG_SCF_FBW7_2	46:53	Mutation altering degron motif	0.7022
p.E75K	TCGA-AO-A03M	BRCA	TCGA	ESISVPDM	DEG_COP1_1	75:82	Mutation altering degron motif	0.7022
p.E75K	DO2216	BRCA	ICGC	ESISVPDM	DEG_COP1_1	75:82	Mutation altering degron motif	0.7022
p.V83M	TCGA-AP-A1DK	UCEC	TCGA	ESISVPDM	DEG_COP1_1	75:82	Mutation rewiring degron network	0.3056
p.V83M	DO42033	UCEC	ICGC	ESISVPDM	DEG_COP1_1	75:82	Mutation rewiring degron network	0.3056
p.E57D	TCGA-AP-A1DK	UCEC	TCGA	MEETPCRE	DEG_SCF_FBW7_2	46:53	Mutation rewiring degron network	0.2222
p.E57D	DO42033	UCEC	ICGC	MEETPCRE	DEG_SCF_FBW7_2	46:53	Mutation rewiring degron network	0.2222
p.D71Y	TCGA-AX-A05Z	UCEC	TCGA	ESISVPDM	DEG_COP1_1	75:82	Mutation rewiring degron network	0.2222
p.D71Y	DO40884	UCEC	ICGC	ESISVPDM	DEG_COP1_1	75:82	Mutation rewiring degron network	0.2222
p.Q44K	TCGA-BA-4078	HNSC	TCGA	MEETPCRE	DEG_SCF_FBW7_2	46:53	Mutation rewiring degron network	0.2778
p.Q44K	DO14173	HNSC	ICGC	MEETPCRE	DEG_SCF_FBW7_2	46:53	Mutation rewiring degron network	0.2778
p.E56K	TCGA-BT-A0YX	BLCA	TCGA	MEETPCRE	DEG_SCF_FBW7_2	46:53	Mutation rewiring degron network	0.25
p.E56K	DO516	BLCA	ICGC	MEETPCRE	DEG_SCF_FBW7_2	46:53	Mutation rewiring degron network	0.25
p.E43K	TCGA-C8-A12P	BRCA	TCGA	MEETPCRE	DEG_SCF_FBW7_2	46:53	Mutation rewiring degron network	0.25
p.E43K	DO4000	BRCA	ICGC	MEETPCRE	DEG_SCF_FBW7_2	46:53	Mutation rewiring degron network	0.25
p.S78L	TCGA-EE-A2MJ	SKCM	TCGA	ESISVPDM	DEG_COP1_1	75:82	Mutation altering degron motif	0.6556
p.S78L	DO38099	SKCM	ICGC	ESISVPDM	DEG_COP1_1	75:82	Mutation altering degron motif	0.6556
p.P90S	TCGA-LP-A5U2	CESC	TCGA	ESISVPDM	DEG_COP1_1	75:82	Mutation rewiring degron network	0.1111
p.P90S	DO51610	CESC	ICGC	ESISVPDM	DEG_COP1_1	75:82	Mutation rewiring degron network	0.1111
p.G72E	TCGA-OD-A75X	SKCM	TCGA	ESISVPDM	DEG_COP1_1	75:82	Mutation rewiring degron network	0.25
p.G72E	DO48601	SKCM	ICGC	ESISVPDM	DEG_COP1_1	75:82	Mutation rewiring degron network	0.25
p.E58D	DO233725	GACA	ICGC	MEETPCRE	DEG_SCF_FBW7_2	46:53	Mutation rewiring degron network	0.1944
p.I77V	DO44832	LICA	ICGC	ESISVPDM	DEG_COP1_1	75:82	Mutation altering degron motif	0.5965
p.E75V	DO228298	MALY	ICGC	ESISVPDM	DEG_COP1_1	75:82	Mutation altering degron motif	0.7693
p.L87R	SIDM01312	Esophageal Carcinoma	GDSC	ESISVPDM	DEG_COP1_1	75:82	Mutation rewiring degron network	0.1944
p.E45V	SIDM00614	Hepatocellular Carcinoma	GDSC	MEETPCRE	DEG_SCF_FBW7_2	46:53	Mutation rewiring degron network	0.3056
p.E45V	ACH-000848	Liver Cancer	CCLE	MEETPCRE	DEG_SCF_FBW7_2	46:53	Mutation rewiring degron network	0.3056
p.E45V	JHH-7	liver	COSMIC	MEETPCRE	DEG_SCF_FBW7_2	46:53	Mutation rewiring degron network	0.3056
p.E45K	SIDM00614	Hepatocellular Carcinoma	GDSC	MEETPCRE	DEG_SCF_FBW7_2	46:53	Mutation rewiring degron network	0.3056
p.E45K	ACH-000848	Liver Cancer	CCLE	MEETPCRE	DEG_SCF_FBW7_2	46:53	Mutation rewiring degron network	0.3056
p.E45K	JHH-7	liver	COSMIC	MEETPCRE	DEG_SCF_FBW7_2	46:53	Mutation rewiring degron network	0.3056
p.P80S	SIDM01007	T-Lymphoblastic Leukemia	GDSC	ESISVPDM	DEG_COP1_1	75:82	Mutation altering degron motif	0.6752
p.P80S	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	ESISVPDM	DEG_COP1_1	75:82	Mutation altering degron motif	0.6752
p.G72R	SIDM00149	Melanoma	GDSC	ESISVPDM	DEG_COP1_1	75:82	Mutation rewiring degron network	0.25
p.G72R	LOXIMVI	skin	COSMIC	ESISVPDM	DEG_COP1_1	75:82	Mutation rewiring degron network	0.25
p.T49S	SIDM00280	Gastric Carcinoma	GDSC	MEETPCRE	DEG_SCF_FBW7_2	46:53	Mutation altering degron motif	0.7116
p.T49S	ECC10	stomach	COSMIC	MEETPCRE	DEG_SCF_FBW7_2	46:53	Mutation altering degron motif	0.7116
p.E53G	SIDM00217	Colorectal Carcinoma	GDSC	MEETPCRE	DEG_SCF_FBW7_2	46:53	Mutation altering degron motif	0.7199
p.E53G	SNU-1040	large intestine	COSMIC	MEETPCRE	DEG_SCF_FBW7_2	46:53	Mutation altering degron motif	0.7199

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRG2

UniProt ID: P13727

Entrez ID: 5553

Protein name: Bone marrow proteoglycan (BMPG) (Proteoglycan 2) [Cleaved into: Eosinophil granule major basic protein (EMBP) (MBP) (Pregnancy-associated major basic protein)]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRG2 in