DegronMD

Uniprot ID: P13727

Source protein: Bone marrow proteoglycan

Source gene: PRG2

Class: DEG_SCF_FBW7_2

Location: 46:53

E3 ligase: FBXW7

DEGRON score: 0.587

ASA_SCORE: 100.7875

COIL: 0.7604

CONS_SCORE: 0.381

DSS_SCORE: 0.8818

HELIX: 0.1683

FCONS_SCORE: 0.977

RIG_SCORE: 0.7232

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G63V	TCGA-17-Z030	LUAD	TCGA	MEETPCRE	DEG_SCF_FBW7_2	0.0556
p.E47D	TCGA-55-7724	LUAD	TCGA	MEETPCRE	DEG_SCF_FBW7_2	0.5647
p.E47D	DO45373	LUAD	ICGC	MEETPCRE	DEG_SCF_FBW7_2	0.5647
p.E39D	TCGA-A1-A0SK	BRCA	TCGA	MEETPCRE	DEG_SCF_FBW7_2	0.1389
p.E39D	DO4143	BRCA	ICGC	MEETPCRE	DEG_SCF_FBW7_2	0.1389
p.G61C	TCGA-A5-A0G1	UCEC	TCGA	MEETPCRE	DEG_SCF_FBW7_2	0.1111
p.G61C	DO42472	UCEC	ICGC	MEETPCRE	DEG_SCF_FBW7_2	0.1111
p.E37D	TCGA-AA-3664	COAD	TCGA	MEETPCRE	DEG_SCF_FBW7_2	0.0833
p.E37D	DO7831	COAD	ICGC	MEETPCRE	DEG_SCF_FBW7_2	0.0833
p.E43D	TCGA-AA-A010	COAD	TCGA	MEETPCRE	DEG_SCF_FBW7_2	0.25
p.E53K	TCGA-AG-A002	READ	TCGA	MEETPCRE	DEG_SCF_FBW7_2	0.7022
p.E57D	TCGA-AP-A1DK	UCEC	TCGA	MEETPCRE	DEG_SCF_FBW7_2	0.2222
p.E57D	DO42033	UCEC	ICGC	MEETPCRE	DEG_SCF_FBW7_2	0.2222
p.Q44K	TCGA-BA-4078	HNSC	TCGA	MEETPCRE	DEG_SCF_FBW7_2	0.2778
p.Q44K	DO14173	HNSC	ICGC	MEETPCRE	DEG_SCF_FBW7_2	0.2778
p.E56K	TCGA-BT-A0YX	BLCA	TCGA	MEETPCRE	DEG_SCF_FBW7_2	0.25
p.E56K	DO516	BLCA	ICGC	MEETPCRE	DEG_SCF_FBW7_2	0.25
p.E43K	TCGA-C8-A12P	BRCA	TCGA	MEETPCRE	DEG_SCF_FBW7_2	0.25
p.E43K	DO4000	BRCA	ICGC	MEETPCRE	DEG_SCF_FBW7_2	0.25
p.E58D	DO233725	GACA	ICGC	MEETPCRE	DEG_SCF_FBW7_2	0.1944
p.E45V	SIDM00614	Hepatocellular Carcinoma	GDSC	MEETPCRE	DEG_SCF_FBW7_2	0.3056
p.E45V	ACH-000848	Liver Cancer	CCLE	MEETPCRE	DEG_SCF_FBW7_2	0.3056
p.E45V	JHH-7	liver	COSMIC	MEETPCRE	DEG_SCF_FBW7_2	0.3056
p.E45K	SIDM00614	Hepatocellular Carcinoma	GDSC	MEETPCRE	DEG_SCF_FBW7_2	0.3056
p.E45K	ACH-000848	Liver Cancer	CCLE	MEETPCRE	DEG_SCF_FBW7_2	0.3056
p.E45K	JHH-7	liver	COSMIC	MEETPCRE	DEG_SCF_FBW7_2	0.3056
p.T49S	SIDM00280	Gastric Carcinoma	GDSC	MEETPCRE	DEG_SCF_FBW7_2	0.7116
p.T49S	ECC10	stomach	COSMIC	MEETPCRE	DEG_SCF_FBW7_2	0.7116
p.E53G	SIDM00217	Colorectal Carcinoma	GDSC	MEETPCRE	DEG_SCF_FBW7_2	0.7199
p.E53G	SNU-1040	large_intestine	COSMIC	MEETPCRE	DEG_SCF_FBW7_2	0.7199

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MEETPCRE

Degron related mutations and impact score

Drug responses associated with PRG2 mutations

All proteins holding degron of MEETPCRE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13727	Bone marrow proteoglycan	DEG_SCF_FBW7_2	46:53	MEETPCRE	FBXW7	0.587	More...