DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_COP1_1

Location: 10860:10868

E3 ligase: COP1

DEGRON score: 0.984

ASA_SCORE: 90.2222

COIL: 0.9263

CONS_SCORE: 0

DSS_SCORE: 0.5625

HELIX: 0.0122

FCONS_SCORE: 0

RIG_SCORE: 0.6216

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S10856C	TCGA-37-4132	LUSC	TCGA	ESSSAVPTP	DEG_COP1_1	0.2222
p.S10856C	DO26528	LUSC	ICGC	ESSSAVPTP	DEG_COP1_1	0.2222
p.G10858A	TCGA-94-A5I4	LUSC	TCGA	ESSSAVPTP	DEG_COP1_1	0.2778
p.G10858A	DO219175	LUSC	ICGC	ESSSAVPTP	DEG_COP1_1	0.2778
p.S10863L	TCGA-EE-A2ML	SKCM	TCGA	ESSSAVPTP	DEG_COP1_1	0.7667
p.S10863L	DO222429	MELA	ICGC	ESSSAVPTP	DEG_COP1_1	0.7667
p.S10863L	DO37408	SKCM	ICGC	ESSSAVPTP	DEG_COP1_1	0.7667
p.P10866L	TCGA-EE-A3J5	SKCM	TCGA	ESSSAVPTP	DEG_COP1_1	0.7582
p.P10866L	DO47331	SKCM	ICGC	ESSSAVPTP	DEG_COP1_1	0.7582
p.G10876R	TCGA-EE-A3JD	SKCM	TCGA	ESSSAVPTP	DEG_COP1_1	0.1111
p.G10876R	DO50299	SKCM	ICGC	ESSSAVPTP	DEG_COP1_1	0.1111
p.S10861F	TCGA-FW-A3R5	SKCM	TCGA	ESSSAVPTP	DEG_COP1_1	0.6871
p.S10861F	DO222875	MELA	ICGC	ESSSAVPTP	DEG_COP1_1	0.6871
p.S10861F	DO37406	SKCM	ICGC	ESSSAVPTP	DEG_COP1_1	0.6871
p.P10875Q	TCGA-GN-A26D	SKCM	TCGA	ESSSAVPTP	DEG_COP1_1	0.1389
p.P10875Q	DO37480	SKCM	ICGC	ESSSAVPTP	DEG_COP1_1	0.1389
p.S10861A	TCGA-UZ-A9PS	KIRP	TCGA	ESSSAVPTP	DEG_COP1_1	0.6477
p.S10861A	DO219709	KIRP	ICGC	ESSSAVPTP	DEG_COP1_1	0.6477
p.S10861A	NEC8	testis	COSMIC	ESSSAVPTP	DEG_COP1_1	0.6477
p.S10861A	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	ESSSAVPTP	DEG_COP1_1	0.6477
p.S10861A	NKM-1	haematopoietic_and_lymphoid_tissue	COSMIC	ESSSAVPTP	DEG_COP1_1	0.6477
p.P10866T	DO229018	LICA	ICGC	ESSSAVPTP	DEG_COP1_1	0.7031
p.T10867N	DO229029	LICA	ICGC	ESSSAVPTP	DEG_COP1_1	0.8166
p.V10874I	DO220898	MELA	ICGC	ESSSAVPTP	DEG_COP1_1	0.1667
p.T10854A	SIDM00958	Chronic Myelogenous Leukemia	GDSC	ESSSAVPTP	DEG_COP1_1	0.1667
p.T10854A	SIDM00576	Acute Myeloid Leukemia	GDSC	ESSSAVPTP	DEG_COP1_1	0.1667
p.T10854A	SIDM00243	Other Solid Cancers	GDSC	ESSSAVPTP	DEG_COP1_1	0.1667
p.T10854A	ACH-000920	Leukemia	CCLE	ESSSAVPTP	DEG_COP1_1	0.1667
p.T10854A	ACH-001197	Lymphoma	CCLE	ESSSAVPTP	DEG_COP1_1	0.1667
p.T10854A	ACH-002288	Embryonal Cancer	CCLE	ESSSAVPTP	DEG_COP1_1	0.1667
p.T10854A	ACH-002290	Leukemia	CCLE	ESSSAVPTP	DEG_COP1_1	0.1667
p.T10854A	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	ESSSAVPTP	DEG_COP1_1	0.1667
p.T10854A	NKM-1	haematopoietic_and_lymphoid_tissue	COSMIC	ESSSAVPTP	DEG_COP1_1	0.1667
p.T10854A	NEC8	testis	COSMIC	ESSSAVPTP	DEG_COP1_1	0.1667
p.S10863T	SIDM00572	Gastric Carcinoma	GDSC	ESSSAVPTP	DEG_COP1_1	0.7116
p.S10863T	ACH-000911	Gastric Cancer	CCLE	ESSSAVPTP	DEG_COP1_1	0.7116
p.S10863T	NUGC-3	stomach	COSMIC	ESSSAVPTP	DEG_COP1_1	0.7116
p.P10866S	SIDM00752	Non-Cancerous	GDSC	ESSSAVPTP	DEG_COP1_1	0.6752

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ESSSAVPTP

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of ESSSAVPTP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_COP1_1	10860:10868	ESSSAVPTP	COP1	0.984	More...