DegronMD

Uniprot ID: Q8TD94

Source protein: Krueppel-like factor 14

Source gene: KLF14

Class: DEG_COP1_1

Location: 142:153

E3 ligase: COP1

DEGRON score: 0.9977

ASA_SCORE: 79.2917

COIL: 0.9493

CONS_SCORE: 0.3486

DSS_SCORE: 0.4678

HELIX: 0.0256

FCONS_SCORE: 1.063

RIG_SCORE: 0.6258

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A159T	TCGA-AZ-4315	COAD	TCGA	ESSSDAPAVPSA	DEG_COP1_1	0.1667
p.A159T	DO8842	COAD	ICGC	ESSSDAPAVPSA	DEG_COP1_1	0.1667
p.P148T	DO229045	LICA	ICGC	ESSSDAPAVPSA	DEG_COP1_1	0.5919
p.D146Y	DO23124	LINC	ICGC	ESSSDAPAVPSA	DEG_COP1_1	0.7325
p.A132T	DO232761	PBCA	ICGC	ESSSDAPAVPSA	DEG_COP1_1	0.0556
p.P151T	SIDM00163	Biliary Tract Carcinoma	GDSC	ESSSDAPAVPSA	DEG_COP1_1	0.7031
p.P151T	SIDM01446	Glioblastoma	GDSC	ESSSDAPAVPSA	DEG_COP1_1	0.7031
p.P151T	SIDM01451	Pancreatic Carcinoma	GDSC	ESSSDAPAVPSA	DEG_COP1_1	0.7031
p.G158A	ACH-002029	Head and Neck Cancer	CCLE	ESSSDAPAVPSA	DEG_COP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TD94	Krueppel-like factor 14	DEG_COP1_1	142:153	ESSSDAPAVPSA	COP1	0.9977	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons