DegronMD

Uniprot ID: A8MW92

Source protein: PHD finger protein 20-like protein 1

Source gene: PHF20L1

Class: DEG_COP1_1

Location: 452:461

E3 ligase: COP1

DEGRON score: 0.5531

ASA_SCORE: 89.97

COIL: 0.8633

CONS_SCORE: 0.4396

DSS_SCORE: 0.5729

HELIX: 0.1094

FCONS_SCORE: 1.0059

RIG_SCORE: 0.6708

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D460Y	TCGA-D3-A2JP	SKCM	TCGA	ESSVPEVPDV	DEG_COP1_1	0.7325
p.D460Y	DO47407	SKCM	ICGC	ESSVPEVPDV	DEG_COP1_1	0.7325
p.L466V	TCGA-DM-A0XD	COAD	TCGA	ESSVPEVPDV	DEG_COP1_1	0.1944
p.L466V	DO10228	COAD	ICGC	ESSVPEVPDV	DEG_COP1_1	0.1944
p.H463Q	DO225360	BRCA	ICGC	ESSVPEVPDV	DEG_COP1_1	0.2778
p.A462S	DO229045	LICA	ICGC	ESSVPEVPDV	DEG_COP1_1	0.3056
p.E457Q	SIDM00772	Breast Carcinoma	GDSC	ESSVPEVPDV	DEG_COP1_1	0.5633
p.E457Q	SIDM00272	Breast Carcinoma	GDSC	ESSVPEVPDV	DEG_COP1_1	0.5633
p.E457Q	ACH-000755	Breast Cancer	CCLE	ESSVPEVPDV	DEG_COP1_1	0.5633
p.E457Q	HCC2218	breast	COSMIC	ESSVPEVPDV	DEG_COP1_1	0.5633
p.E457Q	MDA-MB-453	breast	COSMIC	ESSVPEVPDV	DEG_COP1_1	0.5633
p.S466F	NCI-H2452	pleura	COSMIC	ESSVPEVPDV	DEG_COP1_1	0.1944
p.T458A	KYSE-220	oesophagus	COSMIC	ESSVPEVPDV	DEG_COP1_1	0.7139
p.S467F	NCI-H2452	pleura	COSMIC	ESSVPEVPDV	DEG_COP1_1	0.1667
p.T459A	KYSE-220	oesophagus	COSMIC	ESSVPEVPDV	DEG_COP1_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8MW92	PHD finger protein 20-like protein 1	DEG_COP1_1	452:461	ESSVPEVPDV	COP1	0.5531	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons