DegronMD - A8MW92(PHF20L1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V924I	TCGA-66-2787	LUSC	TCGA	VFVYND	LIG_APCC_ABBA_1	924:929	Mutation altering degron motif	0.5965
p.E934K	TCGA-B5-A11E	UCEC	TCGA	VFVYND	LIG_APCC_ABBA_1	924:929	Mutation rewiring degron network	0.1944
p.E934K	DO227987	COCA	ICGC	VFVYND	LIG_APCC_ABBA_1	924:929	Mutation rewiring degron network	0.1944
p.E934K	DO41644	UCEC	ICGC	VFVYND	LIG_APCC_ABBA_1	924:929	Mutation rewiring degron network	0.1944
p.E934K	SIDM00193	Colorectal Carcinoma	GDSC	VFVYND	LIG_APCC_ABBA_1	924:929	Mutation rewiring degron network	0.1944
p.E934K	SIDM00214	Colorectal Carcinoma	GDSC	VFVYND	LIG_APCC_ABBA_1	924:929	Mutation rewiring degron network	0.1944
p.E934K	SIDM00359	Colorectal Carcinoma	GDSC	VFVYND	LIG_APCC_ABBA_1	924:929	Mutation rewiring degron network	0.1944
p.E934K	ACH-000565	Colon/Colorectal Cancer	CCLE	VFVYND	LIG_APCC_ABBA_1	924:929	Mutation rewiring degron network	0.1944
p.E934K	ACH-000955	Colon/Colorectal Cancer	CCLE	VFVYND	LIG_APCC_ABBA_1	924:929	Mutation rewiring degron network	0.1944
p.E934K	ACH-000991	Colon/Colorectal Cancer	CCLE	VFVYND	LIG_APCC_ABBA_1	924:929	Mutation rewiring degron network	0.1944
p.E934K	SNU-407	large intestine	COSMIC	VFVYND	LIG_APCC_ABBA_1	924:929	Mutation rewiring degron network	0.1944
p.E934K	RCM-1	large intestine	COSMIC	VFVYND	LIG_APCC_ABBA_1	924:929	Mutation rewiring degron network	0.1944
p.E934K	SNU-81	large intestine	COSMIC	VFVYND	LIG_APCC_ABBA_1	924:929	Mutation rewiring degron network	0.1944
p.E238K	TCGA-BT-A2LB	BLCA	TCGA	IATPDVE	DEG_SCF_FBW7_2	222:228	Mutation rewiring degron network	0.0556
p.D460Y	TCGA-D3-A2JP	SKCM	TCGA	ESSVPEVPDV	DEG_COP1_1	452:461	Mutation altering degron motif	0.7325
p.D460Y	DO47407	SKCM	ICGC	ESSVPEVPDV	DEG_COP1_1	452:461	Mutation altering degron motif	0.7325
p.L466V	TCGA-DM-A0XD	COAD	TCGA	ESSVPEVPDV	DEG_COP1_1	452:461	Mutation rewiring degron network	0.1944
p.L466V	DO10228	COAD	ICGC	ESSVPEVPDV	DEG_COP1_1	452:461	Mutation rewiring degron network	0.1944
p.V227I	TCGA-X6-A8C4	SARC	TCGA	IATPDVE	DEG_SCF_FBW7_2	222:228	Mutation altering degron motif	0.5965
p.E212K	DO44098	BLCA	ICGC	IATPDVE	DEG_SCF_FBW7_2	222:228	Mutation rewiring degron network	0.0556
p.H463Q	DO225360	BRCA	ICGC	ESSVPEVPDV	DEG_COP1_1	452:461	Mutation rewiring degron network	0.2778
p.L216H	DO4780	BRCA	ICGC	IATPDVE	DEG_SCF_FBW7_2	222:228	Mutation rewiring degron network	0.1667
p.E927Q	DO234220	ESAD	ICGC	VFVYND	LIG_APCC_ABBA_1	924:929	Mutation altering degron motif	0.6744
p.Q228H	DO229019	LICA	ICGC	IATPDVE	DEG_SCF_FBW7_2	222:228	Mutation altering degron motif	0.7582
p.V231L	DO229022	LICA	ICGC	IATPDVE	DEG_SCF_FBW7_2	222:228	Mutation rewiring degron network	0.25
p.A462S	DO229045	LICA	ICGC	ESSVPEVPDV	DEG_COP1_1	452:461	Mutation rewiring degron network	0.3056
p.V215L	DO229006	LICA	ICGC	IATPDVE	DEG_SCF_FBW7_2	222:228	Mutation substituting flanking lysine	0.25
p.V231I	DO220321	SARC	ICGC	IATPDVE	DEG_SCF_FBW7_2	222:228	Mutation rewiring degron network	0.25
p.P222Q	DO47374	SKCM	ICGC	IATPDVE	DEG_SCF_FBW7_2	222:228	Mutation altering degron motif	0.7035
p.E230D	DO37921	SKCM	ICGC	IATPDVE	DEG_SCF_FBW7_2	222:228	Mutation rewiring degron network	0.2778
p.D226E	SIDM01298	Esophageal Carcinoma	GDSC	IATPDVE	DEG_SCF_FBW7_2	222:228	Mutation altering degron motif	0.5647
p.E457Q	SIDM00772	Breast Carcinoma	GDSC	ESSVPEVPDV	DEG_COP1_1	452:461	Mutation altering degron motif	0.5633
p.E457Q	SIDM00272	Breast Carcinoma	GDSC	ESSVPEVPDV	DEG_COP1_1	452:461	Mutation altering degron motif	0.5633
p.E457Q	ACH-000755	Breast Cancer	CCLE	ESSVPEVPDV	DEG_COP1_1	452:461	Mutation altering degron motif	0.5633
p.E457Q	HCC2218	breast	COSMIC	ESSVPEVPDV	DEG_COP1_1	452:461	Mutation altering degron motif	0.5633
p.E457Q	MDA-MB-453	breast	COSMIC	ESSVPEVPDV	DEG_COP1_1	452:461	Mutation altering degron motif	0.5633
p.T933A	SIDM00143	Small Cell Lung Carcinoma	GDSC	VFVYND	LIG_APCC_ABBA_1	924:929	Mutation rewiring degron network	0.2222
p.T933A	ACH-000803	Lung Cancer	CCLE	VFVYND	LIG_APCC_ABBA_1	924:929	Mutation rewiring degron network	0.2222
p.T933A	HT	haematopoietic and lymphoid tissue	COSMIC	VFVYND	LIG_APCC_ABBA_1	924:929	Mutation rewiring degron network	0.2222
p.T933A	COLO-668	lung	COSMIC	VFVYND	LIG_APCC_ABBA_1	924:929	Mutation rewiring degron network	0.2222
p.T235A	ACH-000930	Breast Cancer	CCLE	IATPDVE	DEG_SCF_FBW7_2	222:228	Mutation rewiring degron network	0.1389
p.T235A	HCC1569	breast	COSMIC	IATPDVE	DEG_SCF_FBW7_2	222:228	Mutation rewiring degron network	0.1389
p.P222S	HCC1954	breast	COSMIC	IATPDVE	DEG_SCF_FBW7_2	222:228	Mutation altering degron motif	0.6752
p.S466F	NCI-H2452	pleura	COSMIC	ESSVPEVPDV	DEG_COP1_1	452:461	Mutation rewiring degron network	0.1944
p.T934A	HT	haematopoietic and lymphoid tissue	COSMIC	VFVYND	LIG_APCC_ABBA_1	924:929	Mutation rewiring degron network	0.1944
p.T458A	KYSE-220	oesophagus	COSMIC	ESSVPEVPDV	DEG_COP1_1	452:461	Mutation altering degron motif	0.7139
p.S467F	NCI-H2452	pleura	COSMIC	ESSVPEVPDV	DEG_COP1_1	452:461	Mutation rewiring degron network	0.1667
p.P223S	HCC1954	breast	COSMIC	IATPDVE	DEG_SCF_FBW7_2	222:228	Mutation altering degron motif	0.6752
p.K238E	CGTH-W-1	thyroid	COSMIC	IATPDVE	DEG_SCF_FBW7_2	222:228	Mutation rewiring degron network	0.0556
p.T459A	KYSE-220	oesophagus	COSMIC	ESSVPEVPDV	DEG_COP1_1	452:461	Mutation altering degron motif	0.7139

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PHF20L1

UniProt ID: A8MW92

Entrez ID: 51105

Protein name: PHD finger protein 20-like protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PHF20L1 in