DegronMD

Uniprot ID: A8MW92

Source protein: PHD finger protein 20-like protein 1

Source gene: PHF20L1

Class: DEG_SCF_FBW7_2

Location: 222:228

E3 ligase: FBXW7

DEGRON score: 0.9084

ASA_SCORE: 94.7286

COIL: 0.8503

CONS_SCORE: 0.452

DSS_SCORE: 0.5345

HELIX: 0.1151

FCONS_SCORE: 0.9939

RIG_SCORE: 0.7617

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E238K	TCGA-BT-A2LB	BLCA	TCGA	IATPDVE	DEG_SCF_FBW7_2	0.0556
p.V227I	TCGA-X6-A8C4	SARC	TCGA	IATPDVE	DEG_SCF_FBW7_2	0.5965
p.E212K	DO44098	BLCA	ICGC	IATPDVE	DEG_SCF_FBW7_2	0.0556
p.L216H	DO4780	BRCA	ICGC	IATPDVE	DEG_SCF_FBW7_2	0.1667
p.Q228H	DO229019	LICA	ICGC	IATPDVE	DEG_SCF_FBW7_2	0.7582
p.V231L	DO229022	LICA	ICGC	IATPDVE	DEG_SCF_FBW7_2	0.25
p.V215L	DO229006	LICA	ICGC	IATPDVE	DEG_SCF_FBW7_2	0.25
p.V231I	DO220321	SARC	ICGC	IATPDVE	DEG_SCF_FBW7_2	0.25
p.P222Q	DO47374	SKCM	ICGC	IATPDVE	DEG_SCF_FBW7_2	0.7035
p.E230D	DO37921	SKCM	ICGC	IATPDVE	DEG_SCF_FBW7_2	0.2778
p.D226E	SIDM01298	Esophageal Carcinoma	GDSC	IATPDVE	DEG_SCF_FBW7_2	0.5647
p.T235A	ACH-000930	Breast Cancer	CCLE	IATPDVE	DEG_SCF_FBW7_2	0.1389
p.T235A	HCC1569	breast	COSMIC	IATPDVE	DEG_SCF_FBW7_2	0.1389
p.P222S	HCC1954	breast	COSMIC	IATPDVE	DEG_SCF_FBW7_2	0.6752
p.P223S	HCC1954	breast	COSMIC	IATPDVE	DEG_SCF_FBW7_2	0.6752
p.K238E	CGTH-W-1	thyroid	COSMIC	IATPDVE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8MW92	PHD finger protein 20-like protein 1	DEG_SCF_FBW7_2	222:228	IATPDVE	FBXW7	0.9084	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons