DegronMD

Uniprot ID: A8MW92

Source protein: PHD finger protein 20-like protein 1

Source gene: PHF20L1

Class: LIG_APCC_ABBA_1

Location: 924:929

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5064

ASA_SCORE: 83.95

COIL: 0.5695

CONS_SCORE: 0.3673

DSS_SCORE: 0.5949

HELIX: 0.15

FCONS_SCORE: 0.9047

RIG_SCORE: 0.7997

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V924I	TCGA-66-2787	LUSC	TCGA	VFVYND	LIG_APCC_ABBA_1	0.5965
p.E934K	TCGA-B5-A11E	UCEC	TCGA	VFVYND	LIG_APCC_ABBA_1	0.1944
p.E934K	DO227987	COCA	ICGC	VFVYND	LIG_APCC_ABBA_1	0.1944
p.E934K	DO41644	UCEC	ICGC	VFVYND	LIG_APCC_ABBA_1	0.1944
p.E934K	SIDM00193	Colorectal Carcinoma	GDSC	VFVYND	LIG_APCC_ABBA_1	0.1944
p.E934K	SIDM00214	Colorectal Carcinoma	GDSC	VFVYND	LIG_APCC_ABBA_1	0.1944
p.E934K	SIDM00359	Colorectal Carcinoma	GDSC	VFVYND	LIG_APCC_ABBA_1	0.1944
p.E934K	ACH-000565	Colon/Colorectal Cancer	CCLE	VFVYND	LIG_APCC_ABBA_1	0.1944
p.E934K	ACH-000955	Colon/Colorectal Cancer	CCLE	VFVYND	LIG_APCC_ABBA_1	0.1944
p.E934K	ACH-000991	Colon/Colorectal Cancer	CCLE	VFVYND	LIG_APCC_ABBA_1	0.1944
p.E934K	SNU-407	large_intestine	COSMIC	VFVYND	LIG_APCC_ABBA_1	0.1944
p.E934K	RCM-1	large_intestine	COSMIC	VFVYND	LIG_APCC_ABBA_1	0.1944
p.E934K	SNU-81	large_intestine	COSMIC	VFVYND	LIG_APCC_ABBA_1	0.1944
p.E927Q	DO234220	ESAD	ICGC	VFVYND	LIG_APCC_ABBA_1	0.6744
p.T933A	SIDM00143	Small Cell Lung Carcinoma	GDSC	VFVYND	LIG_APCC_ABBA_1	0.2222
p.T933A	ACH-000803	Lung Cancer	CCLE	VFVYND	LIG_APCC_ABBA_1	0.2222
p.T933A	HT	haematopoietic_and_lymphoid_tissue	COSMIC	VFVYND	LIG_APCC_ABBA_1	0.2222
p.T933A	COLO-668	lung	COSMIC	VFVYND	LIG_APCC_ABBA_1	0.2222
p.T934A	HT	haematopoietic_and_lymphoid_tissue	COSMIC	VFVYND	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8MW92	PHD finger protein 20-like protein 1	LIG_APCC_ABBA_1	924:929	VFVYND	APC,CDC20,FZR1	0.5064	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons