DegronMD

Uniprot ID: Q9UBS9

Source protein: SUN domain-containing ossification factor

Source gene: SUCO

Class: DEG_COP1_1

Location: 541:552

E3 ligase: COP1

DEGRON score: 0.8791

ASA_SCORE: 89.025

COIL: 0.9321

CONS_SCORE: 0.2411

DSS_SCORE: 0.6648

HELIX: 0.0248

FCONS_SCORE: 0.9533

RIG_SCORE: 0.5893

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H562Y	TCGA-55-8507	LUAD	TCGA	ESTPVSTPVPSP	DEG_COP1_1	0.0556
p.H562Y	ACH-002270	Non-Cancerous	CCLE	ESTPVSTPVPSP	DEG_COP1_1	0.0556
p.H562Y	MC-CAR	haematopoietic_and_lymphoid_tissue	COSMIC	ESTPVSTPVPSP	DEG_COP1_1	0.0556
p.A535T	TCGA-XJ-A9DI	PRAD	TCGA	ESTPVSTPVPSP	DEG_COP1_1	0.1667
p.H558Y	DO222702	MELA	ICGC	ESTPVSTPVPSP	DEG_COP1_1	0.1667
p.R562W	DO232224	PBCA	ICGC	ESTPVSTPVPSP	DEG_COP1_1	0.0556
p.K549T	DO36394	READ	ICGC	ESTPVSTPVPSP	DEG_COP1_1	0.7306
p.G554C	DO47613	SKCM	ICGC	ESTPVSTPVPSP	DEG_COP1_1	0.2778
p.K554N	TE-4	oesophagus	COSMIC	ESTPVSTPVPSP	DEG_COP1_1	0.2778
p.Q542L	RL	haematopoietic_and_lymphoid_tissue	COSMIC	ESTPVSTPVPSP	DEG_COP1_1	0.7765
p.R547C	EN	endometrium	COSMIC	ESTPVSTPVPSP	DEG_COP1_1	0.8301
p.R547H	SNU-1040	large_intestine	COSMIC	ESTPVSTPVPSP	DEG_COP1_1	0.8244
p.A536T	SJRH30	soft_tissue	COSMIC	ESTPVSTPVPSP	DEG_COP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UBS9	SUN domain-containing ossification factor	DEG_COP1_1	541:552	ESTPVSTPVPSP	COP1	0.8791	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons