DegronMD - Q9UBS9(SUCO)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T485A	TCGA-2Y-A9GX	LIHC	TCGA	RQELFDE	LIG_APCC_ABBAyCdc20_2	469:475	Mutation rewiring degron network	0.0556
p.H562Y	TCGA-55-8507	LUAD	TCGA	ESTPVSTPVPSP	DEG_COP1_1	541:552	Mutation rewiring degron network	0.0556
p.H562Y	ACH-002270	Non-Cancerous	CCLE	ESTPVSTPVPSP	DEG_COP1_1	541:552	Mutation rewiring degron network	0.0556
p.H562Y	MC-CAR	haematopoietic and lymphoid tissue	COSMIC	ESTPVSTPVPSP	DEG_COP1_1	541:552	Mutation rewiring degron network	0.0556
p.Q464H	TCGA-AX-A06F	UCEC	TCGA	RQELFDE	LIG_APCC_ABBAyCdc20_2	469:475	Mutation rewiring degron network	0.1944
p.D476G	TCGA-DU-6392	LGG	TCGA	RQELFDE	LIG_APCC_ABBAyCdc20_2	469:475	Mutation rewiring degron network	0.3056
p.R469H	TCGA-E6-A1LX	UCEC	TCGA	RQELFDE	LIG_APCC_ABBAyCdc20_2	469:475	Mutation altering degron motif	0.8244
p.V107M	TCGA-EO-A22U	UCEC	TCGA	VDLHEE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.1389
p.N484T	TCGA-EO-A3AV	UCEC	TCGA	RQELFDE	LIG_APCC_ABBAyCdc20_2	469:475	Mutation rewiring degron network	0.0833
p.D476N	TCGA-L5-A43I	ESCA	TCGA	RQELFDE	LIG_APCC_ABBAyCdc20_2	469:475	Mutation rewiring degron network	0.3056
p.Y465C	TCGA-OL-A5S0	BRCA	TCGA	RQELFDE	LIG_APCC_ABBAyCdc20_2	469:475	Mutation rewiring degron network	0.2222
p.V108M	TCGA-QG-A5Z2	COAD	TCGA	VDLHEE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.1667
p.A535T	TCGA-XJ-A9DI	PRAD	TCGA	ESTPVSTPVPSP	DEG_COP1_1	541:552	Mutation rewiring degron network	0.1667
p.A535T	TCGA-XJ-A9DI	PRAD	TCGA	PESTPVST	DEG_SCF_FBW7_1	540:547	Mutation rewiring degron network	0.1944
p.L117P	DO222990	BTCA	ICGC	VDLHEE	LIG_APCC_ABBA_1	114:119	Mutation altering degron motif	0.7582
p.L117P	DO228941	LICA	ICGC	VDLHEE	LIG_APCC_ABBA_1	114:119	Mutation altering degron motif	0.7582
p.K476N	DO227668	COCA	ICGC	RQELFDE	LIG_APCC_ABBAyCdc20_2	469:475	Mutation rewiring degron network	0.3056
p.K476N	DO219773	UCEC	ICGC	RQELFDE	LIG_APCC_ABBAyCdc20_2	469:475	Mutation rewiring degron network	0.3056
p.K476N	DO43971	UCEC	ICGC	RQELFDE	LIG_APCC_ABBAyCdc20_2	469:475	Mutation rewiring degron network	0.3056
p.R119L	DO228985	LICA	ICGC	VDLHEE	LIG_APCC_ABBA_1	114:119	Mutation altering degron motif	0.8428
p.H558Y	DO222702	MELA	ICGC	ESTPVSTPVPSP	DEG_COP1_1	541:552	Mutation rewiring degron network	0.1667
p.R562W	DO232224	PBCA	ICGC	ESTPVSTPVPSP	DEG_COP1_1	541:552	Mutation rewiring degron network	0.0556
p.K549T	DO36394	READ	ICGC	ESTPVSTPVPSP	DEG_COP1_1	541:552	Mutation altering degron motif	0.7306
p.G554C	DO47613	SKCM	ICGC	ESTPVSTPVPSP	DEG_COP1_1	541:552	Mutation rewiring degron network	0.2778
p.G554C	DO47613	SKCM	ICGC	PESTPVST	DEG_SCF_FBW7_1	540:547	Mutation rewiring degron network	0.1389
p.S470L	SIDM02075	Colorectal Carcinoma	GDSC	RQELFDE	LIG_APCC_ABBAyCdc20_2	469:475	Mutation altering degron motif	0.7667
p.D107G	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	VDLHEE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.1389
p.D107G	HT	haematopoietic and lymphoid tissue	COSMIC	VDLHEE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.1389
p.A484V	SIDM00282	Colorectal Carcinoma	GDSC	RQELFDE	LIG_APCC_ABBAyCdc20_2	469:475	Mutation rewiring degron network	0.0833
p.A484V	CW-2	large intestine	COSMIC	RQELFDE	LIG_APCC_ABBAyCdc20_2	469:475	Mutation rewiring degron network	0.0833
p.S121F	ACH-000500	Head and Neck Cancer	CCLE	VDLHEE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.2778
p.E128K	ACH-000559	Lung Cancer	CCLE	VDLHEE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.0833
p.E128K	NCI-H1836	lung	COSMIC	VDLHEE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.0833
p.D126H	ACH-000643	Breast Cancer	CCLE	VDLHEE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.1389
p.D126H	HDQ-P1	breast	COSMIC	VDLHEE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.1389
p.H466Y	ACH-000867	Lung Cancer	CCLE	RQELFDE	LIG_APCC_ABBAyCdc20_2	469:475	Mutation rewiring degron network	0.25
p.H466Y	ChaGo-K-1	lung	COSMIC	RQELFDE	LIG_APCC_ABBAyCdc20_2	469:475	Mutation rewiring degron network	0.25
p.E128G	ACH-000941	Endometrial/Uterine Cancer	CCLE	VDLHEE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.0833
p.E128G	ACH-000954	Endometrial/Uterine Cancer	CCLE	VDLHEE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.0833
p.E128G	ACH-001517	Endometrial/Uterine Cancer	CCLE	VDLHEE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.0833
p.E128G	HEC-1	endometrium	COSMIC	VDLHEE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.0833
p.V125M	ACH-000985	Colon/Colorectal Cancer	CCLE	VDLHEE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.1667
p.V125M	LS-411N	large intestine	COSMIC	VDLHEE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.1667
p.Y477H	ACH-000990	Endometrial/Uterine Cancer	CCLE	RQELFDE	LIG_APCC_ABBAyCdc20_2	469:475	Mutation rewiring degron network	0.2778
p.P540H	ACH-000997	Colon/Colorectal Cancer	CCLE	PESTPVST	DEG_SCF_FBW7_1	540:547	Mutation altering degron motif	0.7694
p.P540H	ACH-001061	Colon/Colorectal Cancer	CCLE	PESTPVST	DEG_SCF_FBW7_1	540:547	Mutation altering degron motif	0.7694
p.P540H	HCT-15	large intestine	COSMIC	PESTPVST	DEG_SCF_FBW7_1	540:547	Mutation altering degron motif	0.7694
p.V114F	ACH-000999	Colon/Colorectal Cancer	CCLE	VDLHEE	LIG_APCC_ABBA_1	114:119	Mutation altering degron motif	0.5957
p.V114F	SNU-1040	large intestine	COSMIC	VDLHEE	LIG_APCC_ABBA_1	114:119	Mutation altering degron motif	0.5957
p.P480S	ACH-002017	Eye Cancer	CCLE	RQELFDE	LIG_APCC_ABBAyCdc20_2	469:475	Mutation rewiring degron network	0.1944
p.A107E	SNU-C5	large intestine	COSMIC	VDLHEE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.1389
p.A107V	PF-382	haematopoietic and lymphoid tissue	COSMIC	VDLHEE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.1389
p.K554N	TE-4	oesophagus	COSMIC	ESTPVSTPVPSP	DEG_COP1_1	541:552	Mutation rewiring degron network	0.2778
p.K554N	TE-4	oesophagus	COSMIC	PESTPVST	DEG_SCF_FBW7_1	540:547	Mutation rewiring degron network	0.1389
p.Q542L	RL	haematopoietic and lymphoid tissue	COSMIC	ESTPVSTPVPSP	DEG_COP1_1	541:552	Mutation altering degron motif	0.7765
p.Q542L	RL	haematopoietic and lymphoid tissue	COSMIC	PESTPVST	DEG_SCF_FBW7_1	540:547	Mutation altering degron motif	0.7765
p.P485L	DND-41	haematopoietic and lymphoid tissue	COSMIC	RQELFDE	LIG_APCC_ABBAyCdc20_2	469:475	Mutation rewiring degron network	0.0556
p.R547C	EN	endometrium	COSMIC	ESTPVSTPVPSP	DEG_COP1_1	541:552	Mutation altering degron motif	0.8301
p.R547C	EN	endometrium	COSMIC	PESTPVST	DEG_SCF_FBW7_1	540:547	Mutation altering degron motif	0.8301
p.N467K	TE-4	oesophagus	COSMIC	RQELFDE	LIG_APCC_ABBAyCdc20_2	469:475	Mutation rewiring degron network	0.2778
p.P485R	ROS-50	haematopoietic and lymphoid tissue	COSMIC	RQELFDE	LIG_APCC_ABBAyCdc20_2	469:475	Mutation rewiring degron network	0.0556
p.T105N	HCT-15	large intestine	COSMIC	VDLHEE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.0833
p.R547H	SNU-1040	large intestine	COSMIC	ESTPVSTPVPSP	DEG_COP1_1	541:552	Mutation altering degron motif	0.8244
p.R547H	SNU-1040	large intestine	COSMIC	PESTPVST	DEG_SCF_FBW7_1	540:547	Mutation altering degron motif	0.8244
p.A536T	SJRH30	soft tissue	COSMIC	ESTPVSTPVPSP	DEG_COP1_1	541:552	Mutation rewiring degron network	0.1944
p.A536T	SJRH30	soft tissue	COSMIC	PESTPVST	DEG_SCF_FBW7_1	540:547	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SUCO

UniProt ID: Q9UBS9

Entrez ID: 51430

Protein name: SUN domain-containing ossification factor (Membrane protein CH1) (Protein osteopotentia homolog) (SUN-like protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SUCO in