DegronMD

Uniprot ID: Q9UBS9

Source protein: SUN domain-containing ossification factor

Source gene: SUCO

Class: LIG_APCC_ABBAyCdc20_2

Location: 469:475

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8008

ASA_SCORE: 106.9286

COIL: 0.6219

CONS_SCORE: 0.2555

DSS_SCORE: 0.4553

HELIX: 0.3529

FCONS_SCORE: 0.9749

RIG_SCORE: 0.7882

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T485A	TCGA-2Y-A9GX	LIHC	TCGA	RQELFDE	LIG_APCC_ABBAyCdc20_2	0.0556
p.Q464H	TCGA-AX-A06F	UCEC	TCGA	RQELFDE	LIG_APCC_ABBAyCdc20_2	0.1944
p.D476G	TCGA-DU-6392	LGG	TCGA	RQELFDE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R469H	TCGA-E6-A1LX	UCEC	TCGA	RQELFDE	LIG_APCC_ABBAyCdc20_2	0.8244
p.N484T	TCGA-EO-A3AV	UCEC	TCGA	RQELFDE	LIG_APCC_ABBAyCdc20_2	0.0833
p.D476N	TCGA-L5-A43I	ESCA	TCGA	RQELFDE	LIG_APCC_ABBAyCdc20_2	0.3056
p.Y465C	TCGA-OL-A5S0	BRCA	TCGA	RQELFDE	LIG_APCC_ABBAyCdc20_2	0.2222
p.K476N	DO227668	COCA	ICGC	RQELFDE	LIG_APCC_ABBAyCdc20_2	0.3056
p.K476N	DO219773	UCEC	ICGC	RQELFDE	LIG_APCC_ABBAyCdc20_2	0.3056
p.K476N	DO43971	UCEC	ICGC	RQELFDE	LIG_APCC_ABBAyCdc20_2	0.3056
p.S470L	SIDM02075	Colorectal Carcinoma	GDSC	RQELFDE	LIG_APCC_ABBAyCdc20_2	0.7667
p.A484V	SIDM00282	Colorectal Carcinoma	GDSC	RQELFDE	LIG_APCC_ABBAyCdc20_2	0.0833
p.A484V	CW-2	large_intestine	COSMIC	RQELFDE	LIG_APCC_ABBAyCdc20_2	0.0833
p.H466Y	ACH-000867	Lung Cancer	CCLE	RQELFDE	LIG_APCC_ABBAyCdc20_2	0.25
p.H466Y	ChaGo-K-1	lung	COSMIC	RQELFDE	LIG_APCC_ABBAyCdc20_2	0.25
p.Y477H	ACH-000990	Endometrial/Uterine Cancer	CCLE	RQELFDE	LIG_APCC_ABBAyCdc20_2	0.2778
p.P480S	ACH-002017	Eye Cancer	CCLE	RQELFDE	LIG_APCC_ABBAyCdc20_2	0.1944
p.P485L	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	RQELFDE	LIG_APCC_ABBAyCdc20_2	0.0556
p.N467K	TE-4	oesophagus	COSMIC	RQELFDE	LIG_APCC_ABBAyCdc20_2	0.2778
p.P485R	ROS-50	haematopoietic_and_lymphoid_tissue	COSMIC	RQELFDE	LIG_APCC_ABBAyCdc20_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UBS9	SUN domain-containing ossification factor	LIG_APCC_ABBAyCdc20_2	469:475	RQELFDE	APC,CDC20,FZR1	0.8008	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons