DegronMD

Uniprot ID: Q9UBS9

Source protein: SUN domain-containing ossification factor

Source gene: SUCO

Class: LIG_APCC_ABBA_1

Location: 114:119

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6563

ASA_SCORE: 98.7667

COIL: 0.7068

CONS_SCORE: 0.2598

DSS_SCORE: 0.5364

HELIX: 0.1497

FCONS_SCORE: 1.0647

RIG_SCORE: 0.7495

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V107M	TCGA-EO-A22U	UCEC	TCGA	VDLHEE	LIG_APCC_ABBA_1	0.1389
p.V108M	TCGA-QG-A5Z2	COAD	TCGA	VDLHEE	LIG_APCC_ABBA_1	0.1667
p.L117P	DO222990	BTCA	ICGC	VDLHEE	LIG_APCC_ABBA_1	0.7582
p.L117P	DO228941	LICA	ICGC	VDLHEE	LIG_APCC_ABBA_1	0.7582
p.R119L	DO228985	LICA	ICGC	VDLHEE	LIG_APCC_ABBA_1	0.8428
p.D107G	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	VDLHEE	LIG_APCC_ABBA_1	0.1389
p.D107G	HT	haematopoietic_and_lymphoid_tissue	COSMIC	VDLHEE	LIG_APCC_ABBA_1	0.1389
p.S121F	ACH-000500	Head and Neck Cancer	CCLE	VDLHEE	LIG_APCC_ABBA_1	0.2778
p.E128K	ACH-000559	Lung Cancer	CCLE	VDLHEE	LIG_APCC_ABBA_1	0.0833
p.E128K	NCI-H1836	lung	COSMIC	VDLHEE	LIG_APCC_ABBA_1	0.0833
p.D126H	ACH-000643	Breast Cancer	CCLE	VDLHEE	LIG_APCC_ABBA_1	0.1389
p.D126H	HDQ-P1	breast	COSMIC	VDLHEE	LIG_APCC_ABBA_1	0.1389
p.E128G	ACH-000941	Endometrial/Uterine Cancer	CCLE	VDLHEE	LIG_APCC_ABBA_1	0.0833
p.E128G	ACH-000954	Endometrial/Uterine Cancer	CCLE	VDLHEE	LIG_APCC_ABBA_1	0.0833
p.E128G	ACH-001517	Endometrial/Uterine Cancer	CCLE	VDLHEE	LIG_APCC_ABBA_1	0.0833
p.E128G	HEC-1	endometrium	COSMIC	VDLHEE	LIG_APCC_ABBA_1	0.0833
p.V125M	ACH-000985	Colon/Colorectal Cancer	CCLE	VDLHEE	LIG_APCC_ABBA_1	0.1667
p.V125M	LS-411N	large_intestine	COSMIC	VDLHEE	LIG_APCC_ABBA_1	0.1667
p.V114F	ACH-000999	Colon/Colorectal Cancer	CCLE	VDLHEE	LIG_APCC_ABBA_1	0.5957
p.V114F	SNU-1040	large_intestine	COSMIC	VDLHEE	LIG_APCC_ABBA_1	0.5957
p.A107E	SNU-C5	large_intestine	COSMIC	VDLHEE	LIG_APCC_ABBA_1	0.1389
p.A107V	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	VDLHEE	LIG_APCC_ABBA_1	0.1389
p.T105N	HCT-15	large_intestine	COSMIC	VDLHEE	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UBS9	SUN domain-containing ossification factor	LIG_APCC_ABBA_1	114:119	VDLHEE	APC,CDC20,FZR1	0.6563	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VDLHEE

Degron related mutations and impact score

Drug responses associated with SUCO mutations

All proteins holding degron of VDLHEE