DegronMD

Uniprot ID: Q9UBS9

Source protein: SUN domain-containing ossification factor

Source gene: SUCO

Class: DEG_SCF_FBW7_1

Location: 540:547

E3 ligase: FBXW7

DEGRON score: 0.8621

ASA_SCORE: 95.225

COIL: 0.9401

CONS_SCORE: 0.2473

DSS_SCORE: 0.6623

HELIX: 0.0165

FCONS_SCORE: 0.9697

RIG_SCORE: 0.5907

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A535T	TCGA-XJ-A9DI	PRAD	TCGA	PESTPVST	DEG_SCF_FBW7_1	0.1944
p.G554C	DO47613	SKCM	ICGC	PESTPVST	DEG_SCF_FBW7_1	0.1389
p.P540H	ACH-000997	Colon/Colorectal Cancer	CCLE	PESTPVST	DEG_SCF_FBW7_1	0.7694
p.P540H	ACH-001061	Colon/Colorectal Cancer	CCLE	PESTPVST	DEG_SCF_FBW7_1	0.7694
p.P540H	HCT-15	large_intestine	COSMIC	PESTPVST	DEG_SCF_FBW7_1	0.7694
p.K554N	TE-4	oesophagus	COSMIC	PESTPVST	DEG_SCF_FBW7_1	0.1389
p.Q542L	RL	haematopoietic_and_lymphoid_tissue	COSMIC	PESTPVST	DEG_SCF_FBW7_1	0.7765
p.R547C	EN	endometrium	COSMIC	PESTPVST	DEG_SCF_FBW7_1	0.8301
p.R547H	SNU-1040	large_intestine	COSMIC	PESTPVST	DEG_SCF_FBW7_1	0.8244
p.A536T	SJRH30	soft_tissue	COSMIC	PESTPVST	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UBS9	SUN domain-containing ossification factor	DEG_SCF_FBW7_1	540:547	PESTPVST	FBXW7	0.8621	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons