DegronMD

Uniprot ID: P36957

Source protein: Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

Source gene: DLST

Class: DEG_COP1_1

Location: 107:118

E3 ligase: COP1

DEGRON score: 0.7906

ASA_SCORE: 58.55

COIL: 0.5708

CONS_SCORE: 0.6552

DSS_SCORE: 0.4475

HELIX: 0.0151

FCONS_SCORE: 1.1442

RIG_SCORE: 0.7898

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P116Q	TCGA-14-1794	GBM	TCGA	ETDKTSVQVPSP	DEG_COP1_1	0.7035
p.T111P	TCGA-2W-A8YY	CESC	TCGA	ETDKTSVQVPSP	DEG_COP1_1	0.5919
p.E99K	TCGA-A1-A0SI	BRCA	TCGA	ETDKTSVQVPSP	DEG_COP1_1	0.1111
p.E99K	DO1774	BRCA	ICGC	ETDKTSVQVPSP	DEG_COP1_1	0.1111
p.S112Y	TCGA-AP-A059	UCEC	TCGA	ETDKTSVQVPSP	DEG_COP1_1	0.6009
p.S112Y	DO41361	UCEC	ICGC	ETDKTSVQVPSP	DEG_COP1_1	0.6009
p.I123T	TCGA-D1-A17Q	UCEC	TCGA	ETDKTSVQVPSP	DEG_COP1_1	0.1944
p.Q97H	DO447	BLCA	ICGC	ETDKTSVQVPSP	DEG_COP1_1	0.0556
p.V102A	DO232224	PBCA	ICGC	ETDKTSVQVPSP	DEG_COP1_1	0.1944
p.S114Y	DO41572	UCEC	ICGC	ETDKTSVQVPSP	DEG_COP1_1	0.712
p.E107A	SIDM01272	Colorectal Carcinoma	GDSC	ETDKTSVQVPSP	DEG_COP1_1	0.7701

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P36957	Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial	DEG_COP1_1	107:118	ETDKTSVQVPSP	COP1	0.7906	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons