DegronMD

Uniprot ID: Q9UHR4

Source protein: Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1

Source gene: BAIAP2L1

Class: DEG_COP1_1

Location: 404:413

E3 ligase: COP1

DEGRON score: 0.9956

ASA_SCORE: 99.48

COIL: 0.8601

CONS_SCORE: 0.4367

DSS_SCORE: 0.543

HELIX: 0.1262

FCONS_SCORE: 0.7723

RIG_SCORE: 0.7282

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T412M	TCGA-AJ-A3EK	UCEC	TCGA	ETEAVTVPTP	DEG_COP1_1	0.8534
p.T412M	DO233737	GACA	ICGC	ETEAVTVPTP	DEG_COP1_1	0.8534
p.T412M	DO41584	UCEC	ICGC	ETEAVTVPTP	DEG_COP1_1	0.8534
p.S395L	TCGA-AJ-A3EL	UCEC	TCGA	ETEAVTVPTP	DEG_COP1_1	0.5278
p.S395L	DO41542	UCEC	ICGC	ETEAVTVPTP	DEG_COP1_1	0.5278
p.T397M	TCGA-BR-4257	STAD	TCGA	ETEAVTVPTP	DEG_COP1_1	0.5833
p.T397M	DO38683	STAD	ICGC	ETEAVTVPTP	DEG_COP1_1	0.5833
p.S422N	TCGA-BR-8487	STAD	TCGA	ETEAVTVPTP	DEG_COP1_1	0.5278
p.S422N	DO47867	STAD	ICGC	ETEAVTVPTP	DEG_COP1_1	0.5278
p.V418M	TCGA-XK-AAIW	PRAD	TCGA	ETEAVTVPTP	DEG_COP1_1	0.1944
p.V418M	DO51407	PRAD	ICGC	ETEAVTVPTP	DEG_COP1_1	0.1944
p.E404G	DO233760	GACA	ICGC	ETEAVTVPTP	DEG_COP1_1	0.7199
p.L400M	DO229025	LICA	ICGC	ETEAVTVPTP	DEG_COP1_1	0.2222
p.S394L	SIDM00938	Breast Carcinoma	GDSC	ETEAVTVPTP	DEG_COP1_1	0.5
p.S394L	ACH-000902	Breast Cancer	CCLE	ETEAVTVPTP	DEG_COP1_1	0.5
p.S394L	CAL-148	breast	COSMIC	ETEAVTVPTP	DEG_COP1_1	0.5
p.N403D	SIDM00267	Biliary Tract Carcinoma	GDSC	ETEAVTVPTP	DEG_COP1_1	0.3056
p.N403D	ACH-002044	Head and Neck Cancer	CCLE	ETEAVTVPTP	DEG_COP1_1	0.3056
p.N403D	ACH-002312	Gallbladder Cancer	CCLE	ETEAVTVPTP	DEG_COP1_1	0.3056
p.N403D	TGBC24TKB	biliary_tract	COSMIC	ETEAVTVPTP	DEG_COP1_1	0.3056
p.E402Q	ACH-000923	Lymphoma	CCLE	ETEAVTVPTP	DEG_COP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UHR4	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1	DEG_COP1_1	404:413	ETEAVTVPTP	COP1	0.9956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons