DegronMD

Uniprot ID: P08519

Source protein: Apolipoprotein

Source gene: LPA

Class: DEG_COP1_1

Location: 1588:1598

E3 ligase: COP1

DEGRON score: 0.8664

ASA_SCORE: 82.8182

COIL: 0.8569

CONS_SCORE: 0.4505

DSS_SCORE: 0.5252

HELIX: 0.0521

FCONS_SCORE: 1

RIG_SCORE: 0.7434

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1591I	TCGA-05-4417	LUAD	TCGA	ETPTVVPVPSM	DEG_COP1_1	0.7078
p.T1591I	TCGA-VQ-A91D	STAD	TCGA	ETPTVVPVPSM	DEG_COP1_1	0.7078
p.T1591I	DO23570	LUAD	ICGC	ETPTVVPVPSM	DEG_COP1_1	0.7078
p.T1591I	DO51783	STAD	ICGC	ETPTVVPVPSM	DEG_COP1_1	0.7078
p.C1579Y	TCGA-21-5786	LUSC	TCGA	ETPTVVPVPSM	DEG_COP1_1	0.0833
p.C1579Y	DO26830	LUSC	ICGC	ETPTVVPVPSM	DEG_COP1_1	0.0833
p.E1599K	TCGA-22-4613	LUSC	TCGA	ETPTVVPVPSM	DEG_COP1_1	0.3056
p.E1599K	DO26468	LUSC	ICGC	ETPTVVPVPSM	DEG_COP1_1	0.3056
p.P1590L	TCGA-64-5781	LUAD	TCGA	ETPTVVPVPSM	DEG_COP1_1	0.6471
p.P1590L	TCGA-ER-A19M	SKCM	TCGA	ETPTVVPVPSM	DEG_COP1_1	0.6471
p.P1590L	DO23740	LUAD	ICGC	ETPTVVPVPSM	DEG_COP1_1	0.6471
p.P1590L	DO218863	SKCA	ICGC	ETPTVVPVPSM	DEG_COP1_1	0.6471
p.P1590L	DO37798	SKCM	ICGC	ETPTVVPVPSM	DEG_COP1_1	0.6471
p.E1599D	TCGA-AP-A051	UCEC	TCGA	ETPTVVPVPSM	DEG_COP1_1	0.3056
p.E1599D	DO42673	UCEC	ICGC	ETPTVVPVPSM	DEG_COP1_1	0.3056
p.S1602C	TCGA-DK-A3IU	BLCA	TCGA	ETPTVVPVPSM	DEG_COP1_1	0.2222
p.S1602C	DO612	BLCA	ICGC	ETPTVVPVPSM	DEG_COP1_1	0.2222
p.T1589N	TCGA-E6-A1LX	UCEC	TCGA	ETPTVVPVPSM	DEG_COP1_1	0.5944
p.T1589N	DO41020	UCEC	ICGC	ETPTVVPVPSM	DEG_COP1_1	0.5944
p.E1583K	TCGA-EE-A3JD	SKCM	TCGA	ETPTVVPVPSM	DEG_COP1_1	0.1944
p.E1583K	DO220899	MELA	ICGC	ETPTVVPVPSM	DEG_COP1_1	0.1944
p.E1583K	DO50299	SKCM	ICGC	ETPTVVPVPSM	DEG_COP1_1	0.1944
p.S1597I	TCGA-LN-A9FQ	ESCA	TCGA	ETPTVVPVPSM	DEG_COP1_1	0.7341
p.S1597R	DO234209	ESAD	ICGC	ETPTVVPVPSM	DEG_COP1_1	0.7427
p.A1605E	DO229027	LICA	ICGC	ETPTVVPVPSM	DEG_COP1_1	0.1389
p.T1589I	DO50824	LICA	ICGC	ETPTVVPVPSM	DEG_COP1_1	0.5966
p.M1598I	DO220857	MELA	ICGC	ETPTVVPVPSM	DEG_COP1_1	0.6507
p.M1598T	SIDM00454	Rhabdomyosarcoma	GDSC	ETPTVVPVPSM	DEG_COP1_1	0.7423
p.M1598T	SIDM00855	Other Sarcomas	GDSC	ETPTVVPVPSM	DEG_COP1_1	0.7423
p.M1598T	SIDM00863	Burkitt's Lymphoma	GDSC	ETPTVVPVPSM	DEG_COP1_1	0.7423
p.M1598T	SIDM01387	Small Cell Lung Carcinoma	GDSC	ETPTVVPVPSM	DEG_COP1_1	0.7423
p.P1594A	SIDM01174	Cervical Carcinoma	GDSC	ETPTVVPVPSM	DEG_COP1_1	0.6392
p.P1594A	ACH-001402	Cervical Cancer	CCLE	ETPTVVPVPSM	DEG_COP1_1	0.6392
p.P1594A	SW756	cervix	COSMIC	ETPTVVPVPSM	DEG_COP1_1	0.6392
p.H1601N	ACH-000870	Lung Cancer	CCLE	ETPTVVPVPSM	DEG_COP1_1	0.25
p.A1604S	ACH-001370	Ovarian Cancer	CCLE	ETPTVVPVPSM	DEG_COP1_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ETPTVVPVPSM

Degron related mutations and impact score

Drug responses associated with LPA mutations

All proteins holding degron of ETPTVVPVPSM

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P08519	Apolipoprotein	DEG_COP1_1	1588:1598	ETPTVVPVPSM	COP1	0.8664	More...