DegronMD - P08519(LPA)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T1591I	TCGA-05-4417	LUAD	TCGA	ETPTVVPVPSM	DEG_COP1_1	1588:1598	Mutation altering degron motif	0.7078
p.T1591I	TCGA-VQ-A91D	STAD	TCGA	ETPTVVPVPSM	DEG_COP1_1	1588:1598	Mutation altering degron motif	0.7078
p.T1591I	DO23570	LUAD	ICGC	ETPTVVPVPSM	DEG_COP1_1	1588:1598	Mutation altering degron motif	0.7078
p.T1591I	DO51783	STAD	ICGC	ETPTVVPVPSM	DEG_COP1_1	1588:1598	Mutation altering degron motif	0.7078
p.P816L	TCGA-06-0152	GBM	TCGA	PTVTPVPS	DEG_SCF_FBW7_1	800:807	Mutation rewiring degron network	0.0833
p.P816L	DO11238	GBM	ICGC	PTVTPVPS	DEG_SCF_FBW7_1	800:807	Mutation rewiring degron network	0.0833
p.P816L	DO35083	PACA	ICGC	PTVTPVPS	DEG_SCF_FBW7_1	800:807	Mutation rewiring degron network	0.0833
p.P360L	TCGA-06-0152	GBM	TCGA	PTVTPVPS	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.0833
p.P360L	DO11238	GBM	ICGC	PTVTPVPS	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.0833
p.P344L	TCGA-14-0740	GBM	TCGA	PTVTPVPS	DEG_SCF_FBW7_1	344:351	Mutation altering degron motif	0.6471
p.P344L	DO12058	GBM	ICGC	PTVTPVPS	DEG_SCF_FBW7_1	344:351	Mutation altering degron motif	0.6471
p.C1579Y	TCGA-21-5786	LUSC	TCGA	ETPTVVPVPSM	DEG_COP1_1	1588:1598	Mutation rewiring degron network	0.0833
p.C1579Y	DO26830	LUSC	ICGC	ETPTVVPVPSM	DEG_COP1_1	1588:1598	Mutation rewiring degron network	0.0833
p.E1599K	TCGA-22-4613	LUSC	TCGA	ETPTVVPVPSM	DEG_COP1_1	1588:1598	Mutation rewiring degron network	0.3056
p.E1599K	DO26468	LUSC	ICGC	ETPTVVPVPSM	DEG_COP1_1	1588:1598	Mutation rewiring degron network	0.3056
p.A912V	TCGA-30-1714	OV	TCGA	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation rewiring degron network	0.2778
p.A912V	TCGA-AA-A00N	COAD	TCGA	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation rewiring degron network	0.2778
p.A912V	DO9876	COAD	ICGC	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation rewiring degron network	0.2778
p.A912V	DO30850	OV	ICGC	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation rewiring degron network	0.2778
p.A924S	TCGA-55-8302	LUAD	TCGA	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation rewiring degron network	0.25
p.A924S	DO45312	LUAD	ICGC	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation rewiring degron network	0.25
p.P1590L	TCGA-64-5781	LUAD	TCGA	ETPTVVPVPSM	DEG_COP1_1	1588:1598	Mutation altering degron motif	0.6471
p.P1590L	TCGA-ER-A19M	SKCM	TCGA	ETPTVVPVPSM	DEG_COP1_1	1588:1598	Mutation altering degron motif	0.6471
p.P1590L	DO23740	LUAD	ICGC	ETPTVVPVPSM	DEG_COP1_1	1588:1598	Mutation altering degron motif	0.6471
p.P1590L	DO218863	SKCA	ICGC	ETPTVVPVPSM	DEG_COP1_1	1588:1598	Mutation altering degron motif	0.6471
p.P1590L	DO37798	SKCM	ICGC	ETPTVVPVPSM	DEG_COP1_1	1588:1598	Mutation altering degron motif	0.6471
p.V911I	TCGA-A4-7585	KIRP	TCGA	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation rewiring degron network	0.25
p.V911I	TCGA-BR-4292	STAD	TCGA	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation rewiring degron network	0.25
p.V911I	TCGA-G4-6586	COAD	TCGA	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation rewiring degron network	0.25
p.V911I	DO9698	COAD	ICGC	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation rewiring degron network	0.25
p.V911I	DO20757	KIRP	ICGC	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation rewiring degron network	0.25
p.V911I	DO38495	STAD	ICGC	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation rewiring degron network	0.25
p.A228T	TCGA-A5-A0G2	UCEC	TCGA	PTVTPVPS	DEG_SCF_FBW7_1	230:237	Mutation rewiring degron network	0.2778
p.A228T	DO41235	UCEC	ICGC	PTVTPVPS	DEG_SCF_FBW7_1	230:237	Mutation rewiring degron network	0.2778
p.A929T	TCGA-AJ-A3EK	UCEC	TCGA	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation rewiring degron network	0.1111
p.A929T	DO41584	UCEC	ICGC	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation rewiring degron network	0.1111
p.A342T	TCGA-AN-A0AK	BRCA	TCGA	PTVTPVPS	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.2778
p.A342T	TCGA-SJ-A6ZI	UCEC	TCGA	PTVTPVPS	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.2778
p.A342T	DO1608	BRCA	ICGC	PTVTPVPS	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.2778
p.A342T	DO219784	UCEC	ICGC	PTVTPVPS	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.2778
p.E1599D	TCGA-AP-A051	UCEC	TCGA	ETPTVVPVPSM	DEG_COP1_1	1588:1598	Mutation rewiring degron network	0.3056
p.E1599D	DO42673	UCEC	ICGC	ETPTVVPVPSM	DEG_COP1_1	1588:1598	Mutation rewiring degron network	0.3056
p.P918L	TCGA-AP-A0LP	UCEC	TCGA	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation altering degron motif	0.7582
p.P918L	DO43146	UCEC	ICGC	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation altering degron motif	0.7582
p.A912T	TCGA-BG-A0MA	UCEC	TCGA	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation rewiring degron network	0.2778
p.A912T	DO42296	UCEC	ICGC	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation rewiring degron network	0.2778
p.I916V	TCGA-D1-A16G	UCEC	TCGA	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation altering degron motif	0.5965
p.I916V	DO228950	LICA	ICGC	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation altering degron motif	0.5965
p.I916V	DO229030	LICA	ICGC	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation altering degron motif	0.5965
p.I916V	DO43074	UCEC	ICGC	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation altering degron motif	0.5965
p.S1602C	TCGA-DK-A3IU	BLCA	TCGA	ETPTVVPVPSM	DEG_COP1_1	1588:1598	Mutation rewiring degron network	0.2222
p.S1602C	DO612	BLCA	ICGC	ETPTVVPVPSM	DEG_COP1_1	1588:1598	Mutation rewiring degron network	0.2222
p.T1589N	TCGA-E6-A1LX	UCEC	TCGA	ETPTVVPVPSM	DEG_COP1_1	1588:1598	Mutation altering degron motif	0.5944
p.T1589N	DO41020	UCEC	ICGC	ETPTVVPVPSM	DEG_COP1_1	1588:1598	Mutation altering degron motif	0.5944
p.E1583K	TCGA-EE-A3JD	SKCM	TCGA	ETPTVVPVPSM	DEG_COP1_1	1588:1598	Mutation rewiring degron network	0.1944
p.E1583K	DO220899	MELA	ICGC	ETPTVVPVPSM	DEG_COP1_1	1588:1598	Mutation rewiring degron network	0.1944
p.E1583K	DO50299	SKCM	ICGC	ETPTVVPVPSM	DEG_COP1_1	1588:1598	Mutation rewiring degron network	0.1944
p.E907K	TCGA-GF-A6C9	SKCM	TCGA	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation rewiring degron network	0.1389
p.E907K	DO51254	SKCM	ICGC	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation rewiring degron network	0.1389
p.S1597I	TCGA-LN-A9FQ	ESCA	TCGA	ETPTVVPVPSM	DEG_COP1_1	1588:1598	Mutation altering degron motif	0.7341
p.E357K	TCGA-OD-A75X	SKCM	TCGA	PTVTPVPS	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.1667
p.E357K	DO48601	SKCM	ICGC	PTVTPVPS	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.1667
p.E337K	TCGA-XF-A9SY	BLCA	TCGA	PTVTPVPS	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.1389
p.E337K	DO51918	BLCA	ICGC	PTVTPVPS	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.1389
p.T909I	DO50441	ESAD	ICGC	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation rewiring degron network	0.1944
p.S1597R	DO234209	ESAD	ICGC	ETPTVVPVPSM	DEG_COP1_1	1588:1598	Mutation altering degron motif	0.7427
p.P920S	DO222616	ESCA	ICGC	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation altering degron motif	0.5641
p.S921R	DO233718	GACA	ICGC	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation altering degron motif	0.7427
p.A906T	DO50989	LAML	ICGC	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation rewiring degron network	0.1111
p.A1605E	DO229027	LICA	ICGC	ETPTVVPVPSM	DEG_COP1_1	1588:1598	Mutation rewiring degron network	0.1389
p.T1589I	DO50824	LICA	ICGC	ETPTVVPVPSM	DEG_COP1_1	1588:1598	Mutation altering degron motif	0.5966
p.V911F	DO231174	LUSC	ICGC	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation rewiring degron network	0.25
p.M1598I	DO220857	MELA	ICGC	ETPTVVPVPSM	DEG_COP1_1	1588:1598	Mutation altering degron motif	0.6507
p.P344S	DO220875	MELA	ICGC	PTVTPVPS	DEG_SCF_FBW7_1	344:351	Mutation altering degron motif	0.6752
p.L352I	DO220903	MELA	ICGC	PTVTPVPS	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.3056
p.V346A	DO220906	MELA	ICGC	PTVTPVPS	DEG_SCF_FBW7_1	344:351	Mutation altering degron motif	0.5825
p.P918S	DO222395	MELA	ICGC	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation altering degron motif	0.6752
p.P918S	SIDM01570	Ovarian Carcinoma	GDSC	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation altering degron motif	0.6752
p.P918S	ACH-000324	Ovarian Cancer	CCLE	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation altering degron motif	0.6752
p.S926T	DO222843	MELA	ICGC	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation rewiring degron network	0.1944
p.V341I	DO38671	STAD	ICGC	PTVTPVPS	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.25
p.V341I	EW-16	bone	COSMIC	PTVTPVPS	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.25
p.A340V	DO229542	UTCA	ICGC	PTVTPVPS	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.2222
p.A340V	NCI-SNU-1	stomach	COSMIC	PTVTPVPS	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.2222
p.M1598T	SIDM00454	Rhabdomyosarcoma	GDSC	ETPTVVPVPSM	DEG_COP1_1	1588:1598	Mutation altering degron motif	0.7423
p.M1598T	SIDM00855	Other Sarcomas	GDSC	ETPTVVPVPSM	DEG_COP1_1	1588:1598	Mutation altering degron motif	0.7423
p.M1598T	SIDM00863	Burkitt's Lymphoma	GDSC	ETPTVVPVPSM	DEG_COP1_1	1588:1598	Mutation altering degron motif	0.7423
p.M1598T	SIDM01387	Small Cell Lung Carcinoma	GDSC	ETPTVVPVPSM	DEG_COP1_1	1588:1598	Mutation altering degron motif	0.7423
p.P1594A	SIDM01174	Cervical Carcinoma	GDSC	ETPTVVPVPSM	DEG_COP1_1	1588:1598	Mutation altering degron motif	0.6392
p.P1594A	ACH-001402	Cervical Cancer	CCLE	ETPTVVPVPSM	DEG_COP1_1	1588:1598	Mutation altering degron motif	0.6392
p.P1594A	SW756	cervix	COSMIC	ETPTVVPVPSM	DEG_COP1_1	1588:1598	Mutation altering degron motif	0.6392
p.E927K	SIDM01174	Cervical Carcinoma	GDSC	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation rewiring degron network	0.1667
p.E927K	ACH-001402	Cervical Cancer	CCLE	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation rewiring degron network	0.1667
p.E927K	SW756	cervix	COSMIC	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation rewiring degron network	0.1667
p.P930Q	SIDM00156	Neuroblastoma	GDSC	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation rewiring degron network	0.0833
p.P930Q	ACH-002285	Neuroblastoma	CCLE	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation rewiring degron network	0.0833
p.P930Q	NB7	autonomic ganglia	COSMIC	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation rewiring degron network	0.0833
p.P913T	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation rewiring degron network	0.3056
p.P913T	SIDM00757	Non-Small Cell Lung Carcinoma	GDSC	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation rewiring degron network	0.3056
p.P913T	ACH-000590	Lung Cancer	CCLE	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation rewiring degron network	0.3056
p.P913T	ACH-001137	Lung Cancer	CCLE	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation rewiring degron network	0.3056
p.P913T	NCI-H1993	lung	COSMIC	PTITPIPS	DEG_SCF_FBW7_1	914:921	Mutation rewiring degron network	0.3056
p.H1601N	ACH-000870	Lung Cancer	CCLE	ETPTVVPVPSM	DEG_COP1_1	1588:1598	Mutation rewiring degron network	0.25
p.A1604S	ACH-001370	Ovarian Cancer	CCLE	ETPTVVPVPSM	DEG_COP1_1	1588:1598	Mutation rewiring degron network	0.1667
p.P125S	A375	skin	COSMIC	PTVTPVPS	DEG_SCF_FBW7_1	116:123	Mutation rewiring degron network	0.2778
p.A229V	DND-41	haematopoietic and lymphoid tissue	COSMIC	PTVTPVPS	DEG_SCF_FBW7_1	230:237	Mutation rewiring degron network	0.3056
p.P350S	IGR-1	skin	COSMIC	PTVTPVPS	DEG_SCF_FBW7_1	344:351	Mutation altering degron motif	0.5641
p.R449M	NCI-H1648	lung	COSMIC	PTVTPVPS	DEG_SCF_FBW7_1	458:465	Mutation rewiring degron network	0.0833
p.P355L	Mewo	skin	COSMIC	PTVTPVPS	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.2222
p.P355L	IMR-5	autonomic ganglia	COSMIC	PTVTPVPS	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.2222
p.E353K	IPC-298	skin	COSMIC	PTVTPVPS	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.2778
p.R449S	NCI-H1648	lung	COSMIC	PTVTPVPS	DEG_SCF_FBW7_1	458:465	Mutation rewiring degron network	0.0833
p.A354T	C-33-A	cervix	COSMIC	PTVTPVPS	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.25
p.A115V	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	PTVTPVPS	DEG_SCF_FBW7_1	116:123	Mutation rewiring degron network	0.3056
p.G563C	NCI-H209	lung	COSMIC	PTVTPVPS	DEG_SCF_FBW7_1	572:579	Mutation rewiring degron network	0.0833
p.R465S	NCI-H250	lung	COSMIC	PTVTPVPS	DEG_SCF_FBW7_1	458:465	Mutation altering degron motif	0.7427
p.R123M	H513	pleura	COSMIC	PTVTPVPS	DEG_SCF_FBW7_1	116:123	Mutation altering degron motif	0.8632
p.P127S	H513	pleura	COSMIC	PTVTPVPS	DEG_SCF_FBW7_1	116:123	Mutation rewiring degron network	0.2222
p.A342V	NCI-H747	large intestine	COSMIC	PTVTPVPS	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.2778
p.Y235H	IPC-298	skin	COSMIC	PTVTPVPS	DEG_SCF_FBW7_1	230:237	Mutation altering degron motif	0.7229
p.P355S	Mewo	skin	COSMIC	PTVTPVPS	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.2222
p.A343V	SNU-175	large intestine	COSMIC	PTVTPVPS	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.3056
p.G563V	NCI-H209	lung	COSMIC	PTVTPVPS	DEG_SCF_FBW7_1	572:579	Mutation rewiring degron network	0.0833
p.S356F	GCT	soft tissue	COSMIC	PTVTPVPS	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LPA

UniProt ID: P08519

Entrez ID:

Protein name: Apolipoprotein(a) (Apo(a)) (Lp(a)) (EC 3.4.21.-)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for LPA in