DegronMD

Uniprot ID: P08519

Source protein: Apolipoprotein

Source gene: LPA

Class: DEG_SCF_FBW7_1

Location: 344:351

E3 ligase: FBXW7

DEGRON score: 0.9853

ASA_SCORE: 73.6375

COIL: 0.8288

CONS_SCORE: 0.6536

DSS_SCORE: 0.6327

HELIX: 0.0208

FCONS_SCORE: 1.0142

RIG_SCORE: 0.6993

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P360L	TCGA-06-0152	GBM	TCGA	PTVTPVPS	DEG_SCF_FBW7_1	0.0833
p.P360L	DO11238	GBM	ICGC	PTVTPVPS	DEG_SCF_FBW7_1	0.0833
p.P344L	TCGA-14-0740	GBM	TCGA	PTVTPVPS	DEG_SCF_FBW7_1	0.6471
p.P344L	DO12058	GBM	ICGC	PTVTPVPS	DEG_SCF_FBW7_1	0.6471
p.A342T	TCGA-AN-A0AK	BRCA	TCGA	PTVTPVPS	DEG_SCF_FBW7_1	0.2778
p.A342T	TCGA-SJ-A6ZI	UCEC	TCGA	PTVTPVPS	DEG_SCF_FBW7_1	0.2778
p.A342T	DO1608	BRCA	ICGC	PTVTPVPS	DEG_SCF_FBW7_1	0.2778
p.A342T	DO219784	UCEC	ICGC	PTVTPVPS	DEG_SCF_FBW7_1	0.2778
p.E357K	TCGA-OD-A75X	SKCM	TCGA	PTVTPVPS	DEG_SCF_FBW7_1	0.1667
p.E357K	DO48601	SKCM	ICGC	PTVTPVPS	DEG_SCF_FBW7_1	0.1667
p.E337K	TCGA-XF-A9SY	BLCA	TCGA	PTVTPVPS	DEG_SCF_FBW7_1	0.1389
p.E337K	DO51918	BLCA	ICGC	PTVTPVPS	DEG_SCF_FBW7_1	0.1389
p.P344S	DO220875	MELA	ICGC	PTVTPVPS	DEG_SCF_FBW7_1	0.6752
p.L352I	DO220903	MELA	ICGC	PTVTPVPS	DEG_SCF_FBW7_1	0.3056
p.V346A	DO220906	MELA	ICGC	PTVTPVPS	DEG_SCF_FBW7_1	0.5825
p.V341I	DO38671	STAD	ICGC	PTVTPVPS	DEG_SCF_FBW7_1	0.25
p.V341I	EW-16	bone	COSMIC	PTVTPVPS	DEG_SCF_FBW7_1	0.25
p.A340V	DO229542	UTCA	ICGC	PTVTPVPS	DEG_SCF_FBW7_1	0.2222
p.A340V	NCI-SNU-1	stomach	COSMIC	PTVTPVPS	DEG_SCF_FBW7_1	0.2222
p.P350S	IGR-1	skin	COSMIC	PTVTPVPS	DEG_SCF_FBW7_1	0.5641
p.P355L	Mewo	skin	COSMIC	PTVTPVPS	DEG_SCF_FBW7_1	0.2222
p.P355L	IMR-5	autonomic_ganglia	COSMIC	PTVTPVPS	DEG_SCF_FBW7_1	0.2222
p.E353K	IPC-298	skin	COSMIC	PTVTPVPS	DEG_SCF_FBW7_1	0.2778
p.A354T	C-33-A	cervix	COSMIC	PTVTPVPS	DEG_SCF_FBW7_1	0.25
p.A342V	NCI-H747	large_intestine	COSMIC	PTVTPVPS	DEG_SCF_FBW7_1	0.2778
p.P355S	Mewo	skin	COSMIC	PTVTPVPS	DEG_SCF_FBW7_1	0.2222
p.A343V	SNU-175	large_intestine	COSMIC	PTVTPVPS	DEG_SCF_FBW7_1	0.3056
p.S356F	GCT	soft_tissue	COSMIC	PTVTPVPS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P08519	Apolipoprotein	DEG_SCF_FBW7_1	116:123	PTVTPVPS	FBXW7	0.9872	More...
P08519	Apolipoprotein	DEG_SCF_FBW7_1	230:237	PTVTPVPS	FBXW7	0.9919	More...
P08519	Apolipoprotein	DEG_SCF_FBW7_1	344:351	PTVTPVPS	FBXW7	0.9853	More...
P08519	Apolipoprotein	DEG_SCF_FBW7_1	458:465	PTVTPVPS	FBXW7	0.9769	More...
P08519	Apolipoprotein	DEG_SCF_FBW7_1	572:579	PTVTPVPS	FBXW7	0.9871	More...
P08519	Apolipoprotein	DEG_SCF_FBW7_1	686:693	PTVTPVPS	FBXW7	0.9901	More...
P08519	Apolipoprotein	DEG_SCF_FBW7_1	800:807	PTVTPVPS	FBXW7	0.9923	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTVTPVPS

Degron related mutations and impact score

Drug responses associated with LPA mutations

All proteins holding degron of PTVTPVPS