DegronMD

Uniprot ID: P08519

Source protein: Apolipoprotein

Source gene: LPA

Class: DEG_SCF_FBW7_1

Location: 116:123

E3 ligase: FBXW7

DEGRON score: 0.9872

ASA_SCORE: 74.2375

COIL: 0.8179

CONS_SCORE: 0.5941

DSS_SCORE: 0.6327

HELIX: 0.0185

FCONS_SCORE: 1.0193

RIG_SCORE: 0.6993

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P125S	A375	skin	COSMIC	PTVTPVPS	DEG_SCF_FBW7_1	0.2778
p.A115V	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	PTVTPVPS	DEG_SCF_FBW7_1	0.3056
p.R123M	H513	pleura	COSMIC	PTVTPVPS	DEG_SCF_FBW7_1	0.8632
p.P127S	H513	pleura	COSMIC	PTVTPVPS	DEG_SCF_FBW7_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons