DegronMD

Uniprot ID: P08519

Source protein: Apolipoprotein

Source gene: LPA

Class: DEG_SCF_FBW7_1

Location: 800:807

E3 ligase: FBXW7

DEGRON score: 0.9923

ASA_SCORE: 75.75

COIL: 0.879

CONS_SCORE: 0.4505

DSS_SCORE: 0.6327

HELIX: 0.0184

FCONS_SCORE: 1

RIG_SCORE: 0.6993

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P816L	TCGA-06-0152	GBM	TCGA	PTVTPVPS	DEG_SCF_FBW7_1	0.0833
p.P816L	DO11238	GBM	ICGC	PTVTPVPS	DEG_SCF_FBW7_1	0.0833
p.P816L	DO35083	PACA	ICGC	PTVTPVPS	DEG_SCF_FBW7_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons