DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PTVTPVPS
Uniprot ID:
P08519
Source protein:
Apolipoprotein
Source gene:
LPA
Class:
DEG_SCF_FBW7_1
Location:
686:693
E3 ligase:
FBXW7
DEGRON score:
0.9901
ASA_SCORE:
73.9125
COIL:
0.834
CONS_SCORE:
0.4505
DSS_SCORE:
0.6327
HELIX:
0.0184
FCONS_SCORE:
1
RIG_SCORE:
0.6993
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with LPA mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PTVTPVPS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P08519
Apolipoprotein
DEG_SCF_FBW7_1
116:123
PTVTPVPS
FBXW7
0.9872
More...
P08519
Apolipoprotein
DEG_SCF_FBW7_1
230:237
PTVTPVPS
FBXW7
0.9919
More...
P08519
Apolipoprotein
DEG_SCF_FBW7_1
344:351
PTVTPVPS
FBXW7
0.9853
More...
P08519
Apolipoprotein
DEG_SCF_FBW7_1
458:465
PTVTPVPS
FBXW7
0.9769
More...
P08519
Apolipoprotein
DEG_SCF_FBW7_1
572:579
PTVTPVPS
FBXW7
0.9871
More...
P08519
Apolipoprotein
DEG_SCF_FBW7_1
686:693
PTVTPVPS
FBXW7
0.9901
More...
P08519
Apolipoprotein
DEG_SCF_FBW7_1
800:807
PTVTPVPS
FBXW7
0.9923
More...