DegronMD

Uniprot ID: P08519

Source protein: Apolipoprotein

Source gene: LPA

Class: DEG_SCF_FBW7_1

Location: 458:465

E3 ligase: FBXW7

DEGRON score: 0.9769

ASA_SCORE: 73.9625

COIL: 0.8633

CONS_SCORE: 0.5795

DSS_SCORE: 0.6327

HELIX: 0.0189

FCONS_SCORE: 0.9714

RIG_SCORE: 0.6993

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R449M	NCI-H1648	lung	COSMIC	PTVTPVPS	DEG_SCF_FBW7_1	0.0833
p.R449S	NCI-H1648	lung	COSMIC	PTVTPVPS	DEG_SCF_FBW7_1	0.0833
p.R465S	NCI-H250	lung	COSMIC	PTVTPVPS	DEG_SCF_FBW7_1	0.7427

DegronMD: protein-targeted degradation, mutation and drug response to degrons