DegronMD

Uniprot ID: P08519

Source protein: Apolipoprotein

Source gene: LPA

Class: DEG_SCF_FBW7_1

Location: 230:237

E3 ligase: FBXW7

DEGRON score: 0.9919

ASA_SCORE: 75.975

COIL: 0.8641

CONS_SCORE: 0.5996

DSS_SCORE: 0.6327

HELIX: 0.0233

FCONS_SCORE: 0.9993

RIG_SCORE: 0.6993

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A228T	TCGA-A5-A0G2	UCEC	TCGA	PTVTPVPS	DEG_SCF_FBW7_1	0.2778
p.A228T	DO41235	UCEC	ICGC	PTVTPVPS	DEG_SCF_FBW7_1	0.2778
p.A229V	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	PTVTPVPS	DEG_SCF_FBW7_1	0.3056
p.Y235H	IPC-298	skin	COSMIC	PTVTPVPS	DEG_SCF_FBW7_1	0.7229

DegronMD: protein-targeted degradation, mutation and drug response to degrons