DegronMD

Uniprot ID: P08519

Source protein: Apolipoprotein

Source gene: LPA

Class: DEG_SCF_FBW7_1

Location: 914:921

E3 ligase: FBXW7

DEGRON score: 0.9985

ASA_SCORE: 73.625

COIL: 0.8309

CONS_SCORE: 0.4505

DSS_SCORE: 0.6346

HELIX: 0.0246

FCONS_SCORE: 1

RIG_SCORE: 0.7167

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A912V	TCGA-30-1714	OV	TCGA	PTITPIPS	DEG_SCF_FBW7_1	0.2778
p.A912V	TCGA-AA-A00N	COAD	TCGA	PTITPIPS	DEG_SCF_FBW7_1	0.2778
p.A912V	DO9876	COAD	ICGC	PTITPIPS	DEG_SCF_FBW7_1	0.2778
p.A912V	DO30850	OV	ICGC	PTITPIPS	DEG_SCF_FBW7_1	0.2778
p.A924S	TCGA-55-8302	LUAD	TCGA	PTITPIPS	DEG_SCF_FBW7_1	0.25
p.A924S	DO45312	LUAD	ICGC	PTITPIPS	DEG_SCF_FBW7_1	0.25
p.V911I	TCGA-A4-7585	KIRP	TCGA	PTITPIPS	DEG_SCF_FBW7_1	0.25
p.V911I	TCGA-BR-4292	STAD	TCGA	PTITPIPS	DEG_SCF_FBW7_1	0.25
p.V911I	TCGA-G4-6586	COAD	TCGA	PTITPIPS	DEG_SCF_FBW7_1	0.25
p.V911I	DO9698	COAD	ICGC	PTITPIPS	DEG_SCF_FBW7_1	0.25
p.V911I	DO20757	KIRP	ICGC	PTITPIPS	DEG_SCF_FBW7_1	0.25
p.V911I	DO38495	STAD	ICGC	PTITPIPS	DEG_SCF_FBW7_1	0.25
p.A929T	TCGA-AJ-A3EK	UCEC	TCGA	PTITPIPS	DEG_SCF_FBW7_1	0.1111
p.A929T	DO41584	UCEC	ICGC	PTITPIPS	DEG_SCF_FBW7_1	0.1111
p.P918L	TCGA-AP-A0LP	UCEC	TCGA	PTITPIPS	DEG_SCF_FBW7_1	0.7582
p.P918L	DO43146	UCEC	ICGC	PTITPIPS	DEG_SCF_FBW7_1	0.7582
p.A912T	TCGA-BG-A0MA	UCEC	TCGA	PTITPIPS	DEG_SCF_FBW7_1	0.2778
p.A912T	DO42296	UCEC	ICGC	PTITPIPS	DEG_SCF_FBW7_1	0.2778
p.I916V	TCGA-D1-A16G	UCEC	TCGA	PTITPIPS	DEG_SCF_FBW7_1	0.5965
p.I916V	DO228950	LICA	ICGC	PTITPIPS	DEG_SCF_FBW7_1	0.5965
p.I916V	DO229030	LICA	ICGC	PTITPIPS	DEG_SCF_FBW7_1	0.5965
p.I916V	DO43074	UCEC	ICGC	PTITPIPS	DEG_SCF_FBW7_1	0.5965
p.E907K	TCGA-GF-A6C9	SKCM	TCGA	PTITPIPS	DEG_SCF_FBW7_1	0.1389
p.E907K	DO51254	SKCM	ICGC	PTITPIPS	DEG_SCF_FBW7_1	0.1389
p.T909I	DO50441	ESAD	ICGC	PTITPIPS	DEG_SCF_FBW7_1	0.1944
p.P920S	DO222616	ESCA	ICGC	PTITPIPS	DEG_SCF_FBW7_1	0.5641
p.S921R	DO233718	GACA	ICGC	PTITPIPS	DEG_SCF_FBW7_1	0.7427
p.A906T	DO50989	LAML	ICGC	PTITPIPS	DEG_SCF_FBW7_1	0.1111
p.V911F	DO231174	LUSC	ICGC	PTITPIPS	DEG_SCF_FBW7_1	0.25
p.P918S	DO222395	MELA	ICGC	PTITPIPS	DEG_SCF_FBW7_1	0.6752
p.P918S	SIDM01570	Ovarian Carcinoma	GDSC	PTITPIPS	DEG_SCF_FBW7_1	0.6752
p.P918S	ACH-000324	Ovarian Cancer	CCLE	PTITPIPS	DEG_SCF_FBW7_1	0.6752
p.S926T	DO222843	MELA	ICGC	PTITPIPS	DEG_SCF_FBW7_1	0.1944
p.E927K	SIDM01174	Cervical Carcinoma	GDSC	PTITPIPS	DEG_SCF_FBW7_1	0.1667
p.E927K	ACH-001402	Cervical Cancer	CCLE	PTITPIPS	DEG_SCF_FBW7_1	0.1667
p.E927K	SW756	cervix	COSMIC	PTITPIPS	DEG_SCF_FBW7_1	0.1667
p.P930Q	SIDM00156	Neuroblastoma	GDSC	PTITPIPS	DEG_SCF_FBW7_1	0.0833
p.P930Q	ACH-002285	Neuroblastoma	CCLE	PTITPIPS	DEG_SCF_FBW7_1	0.0833
p.P930Q	NB7	autonomic_ganglia	COSMIC	PTITPIPS	DEG_SCF_FBW7_1	0.0833
p.P913T	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	PTITPIPS	DEG_SCF_FBW7_1	0.3056
p.P913T	SIDM00757	Non-Small Cell Lung Carcinoma	GDSC	PTITPIPS	DEG_SCF_FBW7_1	0.3056
p.P913T	ACH-000590	Lung Cancer	CCLE	PTITPIPS	DEG_SCF_FBW7_1	0.3056
p.P913T	ACH-001137	Lung Cancer	CCLE	PTITPIPS	DEG_SCF_FBW7_1	0.3056
p.P913T	NCI-H1993	lung	COSMIC	PTITPIPS	DEG_SCF_FBW7_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTITPIPS

Degron related mutations and impact score

Drug responses associated with LPA mutations

All proteins holding degron of PTITPIPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P08519	Apolipoprotein	DEG_SCF_FBW7_1	914:921	PTITPIPS	FBXW7	0.9985	More...