DegronMD

Uniprot ID: P24821

Source protein: Tenascin

Source gene: TNC

Class: DEG_COP1_1

Location: 1250:1259

E3 ligase: COP1

DEGRON score: 0.8288

ASA_SCORE: 76.5

COIL: 0.5376

CONS_SCORE: 0.4183

DSS_SCORE: 0.3399

HELIX: 0.0301

FCONS_SCORE: 1.0243

RIG_SCORE: 0.8494

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1258D	DO219773	UCEC	ICGC	EVLTEEVPDM	DEG_COP1_1	0.7198
p.L1259M	DO228952	LICA	ICGC	EVLTEEVPDM	DEG_COP1_1	0.711
p.P1257Q	TCGA-EE-A2GT	SKCM	TCGA	EVLTEEVPDM	DEG_COP1_1	0.7035
p.P1257Q	DO37946	SKCM	ICGC	EVLTEEVPDM	DEG_COP1_1	0.7035
p.P1258Q	NCI-H1048	lung	COSMIC	EVLTEEVPDM	DEG_COP1_1	0.7035
p.L1256F	LU-139	lung	COSMIC	EVLTEEVPDM	DEG_COP1_1	0.6981
p.D1258N	TCGA-CV-A45P	HNSC	TCGA	EVLTEEVPDM	DEG_COP1_1	0.6932
p.D1258N	DO219026	HNSC	ICGC	EVLTEEVPDM	DEG_COP1_1	0.6932
p.P1256S	DO11854	GBM	ICGC	EVLTEEVPDM	DEG_COP1_1	0.6752
p.E1255G	TCGA-AN-A0AK	BRCA	TCGA	EVLTEEVPDM	DEG_COP1_1	0.6087
p.E1255G	DO1608	BRCA	ICGC	EVLTEEVPDM	DEG_COP1_1	0.6087
p.E1254K	TCGA-EB-A551	SKCM	TCGA	EVLTEEVPDM	DEG_COP1_1	0.591
p.E1254K	DO47453	SKCM	ICGC	EVLTEEVPDM	DEG_COP1_1	0.591
p.L1252F	TCGA-KQ-A41N	BLCA	TCGA	EVLTEEVPDM	DEG_COP1_1	0.587
p.L1252F	DO223588	BLCA	ICGC	EVLTEEVPDM	DEG_COP1_1	0.587
p.L1252V	TCGA-E6-A1LX	UCEC	TCGA	EVLTEEVPDM	DEG_COP1_1	0.5654
p.L1252V	DO41020	UCEC	ICGC	EVLTEEVPDM	DEG_COP1_1	0.5654
p.E1255D	TCGA-BR-8680	STAD	TCGA	EVLTEEVPDM	DEG_COP1_1	0.5647
p.E1255D	DO47769	STAD	ICGC	EVLTEEVPDM	DEG_COP1_1	0.5647
p.G1260E	TCGA-FW-A3R5	SKCM	TCGA	EVLTEEVPDM	DEG_COP1_1	0.3056
p.G1260E	TCGA-VS-A94W	CESC	TCGA	EVLTEEVPDM	DEG_COP1_1	0.3056
p.G1260E	DO219726	CESC	ICGC	EVLTEEVPDM	DEG_COP1_1	0.3056
p.G1260E	DO37406	SKCM	ICGC	EVLTEEVPDM	DEG_COP1_1	0.3056
p.T1249I	DO234203	ESAD	ICGC	EVLTEEVPDM	DEG_COP1_1	0.3056
p.T1249I	DO218840	SKCA	ICGC	EVLTEEVPDM	DEG_COP1_1	0.3056

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P24821	Tenascin	DEG_COP1_1	1250:1259	EVLTEEVPDM	COP1	0.8288	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons