DegronMD

Uniprot ID: P24821

Source protein: Tenascin

Source gene: TNC

Class: DEG_COP1_1

Location: 1250:1259

E3 ligase: COP1

DEGRON score: 0.8288

ASA_SCORE: 76.5

COIL: 0.5376

CONS_SCORE: 0.4183

DSS_SCORE: 0.3399

HELIX: 0.0301

FCONS_SCORE: 1.0243

RIG_SCORE: 0.8494

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1255G	TCGA-AN-A0AK	BRCA	TCGA	EVLTEEVPDM	DEG_COP1_1	0.6087
p.E1255G	DO1608	BRCA	ICGC	EVLTEEVPDM	DEG_COP1_1	0.6087
p.E1255D	TCGA-BR-8680	STAD	TCGA	EVLTEEVPDM	DEG_COP1_1	0.5647
p.E1255D	DO47769	STAD	ICGC	EVLTEEVPDM	DEG_COP1_1	0.5647
p.F1242V	TCGA-CD-A48A	STAD	TCGA	EVLTEEVPDM	DEG_COP1_1	0.1111
p.F1242V	DO47781	STAD	ICGC	EVLTEEVPDM	DEG_COP1_1	0.1111
p.D1258N	TCGA-CV-A45P	HNSC	TCGA	EVLTEEVPDM	DEG_COP1_1	0.6932
p.D1258N	DO219026	HNSC	ICGC	EVLTEEVPDM	DEG_COP1_1	0.6932
p.T1245S	TCGA-DU-A5TP	LGG	TCGA	EVLTEEVPDM	DEG_COP1_1	0.1944
p.T1245S	DO44562	LGG	ICGC	EVLTEEVPDM	DEG_COP1_1	0.1944
p.L1252V	TCGA-E6-A1LX	UCEC	TCGA	EVLTEEVPDM	DEG_COP1_1	0.5654
p.L1252V	DO41020	UCEC	ICGC	EVLTEEVPDM	DEG_COP1_1	0.5654
p.E1254K	TCGA-EB-A551	SKCM	TCGA	EVLTEEVPDM	DEG_COP1_1	0.591
p.E1254K	DO47453	SKCM	ICGC	EVLTEEVPDM	DEG_COP1_1	0.591
p.P1257Q	TCGA-EE-A2GT	SKCM	TCGA	EVLTEEVPDM	DEG_COP1_1	0.7035
p.P1257Q	DO37946	SKCM	ICGC	EVLTEEVPDM	DEG_COP1_1	0.7035
p.G1260E	TCGA-FW-A3R5	SKCM	TCGA	EVLTEEVPDM	DEG_COP1_1	0.3056
p.G1260E	TCGA-VS-A94W	CESC	TCGA	EVLTEEVPDM	DEG_COP1_1	0.3056
p.G1260E	DO219726	CESC	ICGC	EVLTEEVPDM	DEG_COP1_1	0.3056
p.G1260E	DO37406	SKCM	ICGC	EVLTEEVPDM	DEG_COP1_1	0.3056
p.L1252F	TCGA-KQ-A41N	BLCA	TCGA	EVLTEEVPDM	DEG_COP1_1	0.587
p.L1252F	DO223588	BLCA	ICGC	EVLTEEVPDM	DEG_COP1_1	0.587
p.T1249I	DO234203	ESAD	ICGC	EVLTEEVPDM	DEG_COP1_1	0.3056
p.T1249I	DO218840	SKCA	ICGC	EVLTEEVPDM	DEG_COP1_1	0.3056
p.N1261K	DO233132	GACA	ICGC	EVLTEEVPDM	DEG_COP1_1	0.2778
p.A1262V	DO233731	GACA	ICGC	EVLTEEVPDM	DEG_COP1_1	0.25
p.P1256S	DO11854	GBM	ICGC	EVLTEEVPDM	DEG_COP1_1	0.6752
p.E1241G	DO219699	KIRP	ICGC	EVLTEEVPDM	DEG_COP1_1	0.0833
p.L1259M	DO228952	LICA	ICGC	EVLTEEVPDM	DEG_COP1_1	0.711
p.D1266E	DO228974	LICA	ICGC	EVLTEEVPDM	DEG_COP1_1	0.1389
p.A1241D	DO229019	LICA	ICGC	EVLTEEVPDM	DEG_COP1_1	0.0833
p.T1263I	DO224563	LUSC	ICGC	EVLTEEVPDM	DEG_COP1_1	0.2222
p.E1243G	DO232224	PBCA	ICGC	EVLTEEVPDM	DEG_COP1_1	0.1389
p.N1261S	DO218886	SKCA	ICGC	EVLTEEVPDM	DEG_COP1_1	0.2778
p.E1241K	DO37406	SKCM	ICGC	EVLTEEVPDM	DEG_COP1_1	0.0833
p.G1258D	DO219773	UCEC	ICGC	EVLTEEVPDM	DEG_COP1_1	0.7198
p.E1266D	SIDM01662	Plasma Cell Myeloma	GDSC	EVLTEEVPDM	DEG_COP1_1	0.1389
p.E1266D	ACH-000564	Myeloma	CCLE	EVLTEEVPDM	DEG_COP1_1	0.1389
p.V1264L	ACH-000695	Lung Cancer	CCLE	EVLTEEVPDM	DEG_COP1_1	0.1944
p.L1256F	LU-139	lung	COSMIC	EVLTEEVPDM	DEG_COP1_1	0.6981
p.P1258Q	NCI-H1048	lung	COSMIC	EVLTEEVPDM	DEG_COP1_1	0.7035

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: EVLTEEVPDM

Degron related mutations and impact score

Drug responses associated with TNC mutations

All proteins holding degron of EVLTEEVPDM

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P24821	Tenascin	DEG_COP1_1	1250:1259	EVLTEEVPDM	COP1	0.8288	More...