DegronMD - P24821(TNC)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1843H	TCGA-A7-A0CE	BRCA	TCGA	SYTGEKVPEI	DEG_COP1_1	1832:1841	Mutation rewiring degron network	0.2778
p.E1255G	TCGA-AN-A0AK	BRCA	TCGA	EVLTEEVPDM	DEG_COP1_1	1250:1259	Mutation altering degron motif	0.6087
p.E1255G	DO1608	BRCA	ICGC	EVLTEEVPDM	DEG_COP1_1	1250:1259	Mutation altering degron motif	0.6087
p.E1255D	TCGA-BR-8680	STAD	TCGA	EVLTEEVPDM	DEG_COP1_1	1250:1259	Mutation altering degron motif	0.5647
p.E1255D	DO47769	STAD	ICGC	EVLTEEVPDM	DEG_COP1_1	1250:1259	Mutation altering degron motif	0.5647
p.F1242V	TCGA-CD-A48A	STAD	TCGA	EVLTEEVPDM	DEG_COP1_1	1250:1259	Mutation rewiring degron network	0.1111
p.F1242V	DO47781	STAD	ICGC	EVLTEEVPDM	DEG_COP1_1	1250:1259	Mutation rewiring degron network	0.1111
p.D1258N	TCGA-CV-A45P	HNSC	TCGA	EVLTEEVPDM	DEG_COP1_1	1250:1259	Mutation altering degron motif	0.6932
p.D1258N	DO219026	HNSC	ICGC	EVLTEEVPDM	DEG_COP1_1	1250:1259	Mutation altering degron motif	0.6932
p.T1245S	TCGA-DU-A5TP	LGG	TCGA	EVLTEEVPDM	DEG_COP1_1	1250:1259	Mutation rewiring degron network	0.1944
p.T1245S	DO44562	LGG	ICGC	EVLTEEVPDM	DEG_COP1_1	1250:1259	Mutation rewiring degron network	0.1944
p.R1843C	TCGA-E6-A1LX	UCEC	TCGA	SYTGEKVPEI	DEG_COP1_1	1832:1841	Mutation rewiring degron network	0.2778
p.L1252V	TCGA-E6-A1LX	UCEC	TCGA	EVLTEEVPDM	DEG_COP1_1	1250:1259	Mutation altering degron motif	0.5654
p.L1252V	DO41020	UCEC	ICGC	EVLTEEVPDM	DEG_COP1_1	1250:1259	Mutation altering degron motif	0.5654
p.E1254K	TCGA-EB-A551	SKCM	TCGA	EVLTEEVPDM	DEG_COP1_1	1250:1259	Mutation altering degron motif	0.591
p.E1254K	DO47453	SKCM	ICGC	EVLTEEVPDM	DEG_COP1_1	1250:1259	Mutation altering degron motif	0.591
p.P1257Q	TCGA-EE-A2GT	SKCM	TCGA	EVLTEEVPDM	DEG_COP1_1	1250:1259	Mutation altering degron motif	0.7035
p.P1257Q	DO37946	SKCM	ICGC	EVLTEEVPDM	DEG_COP1_1	1250:1259	Mutation altering degron motif	0.7035
p.G1260E	TCGA-FW-A3R5	SKCM	TCGA	EVLTEEVPDM	DEG_COP1_1	1250:1259	Mutation rewiring degron network	0.3056
p.G1260E	TCGA-VS-A94W	CESC	TCGA	EVLTEEVPDM	DEG_COP1_1	1250:1259	Mutation rewiring degron network	0.3056
p.G1260E	DO219726	CESC	ICGC	EVLTEEVPDM	DEG_COP1_1	1250:1259	Mutation rewiring degron network	0.3056
p.G1260E	DO37406	SKCM	ICGC	EVLTEEVPDM	DEG_COP1_1	1250:1259	Mutation rewiring degron network	0.3056
p.K1837E	TCGA-H4-A2HQ	BLCA	TCGA	SYTGEKVPEI	DEG_COP1_1	1832:1841	Mutation altering degron motif	0.591
p.L1252F	TCGA-KQ-A41N	BLCA	TCGA	EVLTEEVPDM	DEG_COP1_1	1250:1259	Mutation altering degron motif	0.587
p.L1252F	DO223588	BLCA	ICGC	EVLTEEVPDM	DEG_COP1_1	1250:1259	Mutation altering degron motif	0.587
p.T1249I	DO234203	ESAD	ICGC	EVLTEEVPDM	DEG_COP1_1	1250:1259	Mutation rewiring degron network	0.3056
p.T1249I	DO218840	SKCA	ICGC	EVLTEEVPDM	DEG_COP1_1	1250:1259	Mutation rewiring degron network	0.3056
p.N1261K	DO233132	GACA	ICGC	EVLTEEVPDM	DEG_COP1_1	1250:1259	Mutation rewiring degron network	0.2778
p.A1262V	DO233731	GACA	ICGC	EVLTEEVPDM	DEG_COP1_1	1250:1259	Mutation rewiring degron network	0.25
p.P1256S	DO11854	GBM	ICGC	EVLTEEVPDM	DEG_COP1_1	1250:1259	Mutation altering degron motif	0.6752
p.E1241G	DO219699	KIRP	ICGC	EVLTEEVPDM	DEG_COP1_1	1250:1259	Mutation rewiring degron network	0.0833
p.L1259M	DO228952	LICA	ICGC	EVLTEEVPDM	DEG_COP1_1	1250:1259	Mutation altering degron motif	0.711
p.D1266E	DO228974	LICA	ICGC	EVLTEEVPDM	DEG_COP1_1	1250:1259	Mutation rewiring degron network	0.1389
p.A1241D	DO229019	LICA	ICGC	EVLTEEVPDM	DEG_COP1_1	1250:1259	Mutation rewiring degron network	0.0833
p.T1263I	DO224563	LUSC	ICGC	EVLTEEVPDM	DEG_COP1_1	1250:1259	Mutation rewiring degron network	0.2222
p.E1243G	DO232224	PBCA	ICGC	EVLTEEVPDM	DEG_COP1_1	1250:1259	Mutation rewiring degron network	0.1389
p.N1261S	DO218886	SKCA	ICGC	EVLTEEVPDM	DEG_COP1_1	1250:1259	Mutation rewiring degron network	0.2778
p.E1241K	DO37406	SKCM	ICGC	EVLTEEVPDM	DEG_COP1_1	1250:1259	Mutation rewiring degron network	0.0833
p.G1258D	DO219773	UCEC	ICGC	EVLTEEVPDM	DEG_COP1_1	1250:1259	Mutation altering degron motif	0.7198
p.E1266D	SIDM01662	Plasma Cell Myeloma	GDSC	EVLTEEVPDM	DEG_COP1_1	1250:1259	Mutation rewiring degron network	0.1389
p.E1266D	ACH-000564	Myeloma	CCLE	EVLTEEVPDM	DEG_COP1_1	1250:1259	Mutation rewiring degron network	0.1389
p.V1264L	ACH-000695	Lung Cancer	CCLE	EVLTEEVPDM	DEG_COP1_1	1250:1259	Mutation rewiring degron network	0.1944
p.D1837N	ACH-000773	Lymphoma	CCLE	SYTGEKVPEI	DEG_COP1_1	1832:1841	Mutation altering degron motif	0.6932
p.L1256F	LU-139	lung	COSMIC	EVLTEEVPDM	DEG_COP1_1	1250:1259	Mutation altering degron motif	0.6981
p.R1825C	KM-H2	haematopoietic and lymphoid tissue	COSMIC	SYTGEKVPEI	DEG_COP1_1	1832:1841	Mutation rewiring degron network	0.1389
p.P1258Q	NCI-H1048	lung	COSMIC	EVLTEEVPDM	DEG_COP1_1	1250:1259	Mutation altering degron motif	0.7035
p.R1825H	MIA-PaCa-2	pancreas	COSMIC	SYTGEKVPEI	DEG_COP1_1	1832:1841	Mutation rewiring degron network	0.1389
p.G1846A	IHH-4	thyroid	COSMIC	SYTGEKVPEI	DEG_COP1_1	1832:1841	Mutation blocking phosphorylation signal	0.6389

Kaplan plot for TNC in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TNC

UniProt ID: P24821

Entrez ID: 3371

Protein name: Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (Tenascin-C) (TN-C)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TNC in