DegronMD

Uniprot ID: P24821

Source protein: Tenascin

Source gene: TNC

Class: DEG_COP1_1

Location: 1832:1841

E3 ligase: COP1

DEGRON score: 0.553

ASA_SCORE: 68.41

COIL: 0.5424

CONS_SCORE: 0.606

DSS_SCORE: 0.2099

HELIX: 0.0049

FCONS_SCORE: 1.0314

RIG_SCORE: 0.8046

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1843H	TCGA-A7-A0CE	BRCA	TCGA	SYTGEKVPEI	DEG_COP1_1	0.2778
p.R1843C	TCGA-E6-A1LX	UCEC	TCGA	SYTGEKVPEI	DEG_COP1_1	0.2778
p.K1837E	TCGA-H4-A2HQ	BLCA	TCGA	SYTGEKVPEI	DEG_COP1_1	0.591
p.D1837N	ACH-000773	Lymphoma	CCLE	SYTGEKVPEI	DEG_COP1_1	0.6932
p.R1825C	KM-H2	haematopoietic_and_lymphoid_tissue	COSMIC	SYTGEKVPEI	DEG_COP1_1	0.1389
p.R1825H	MIA-PaCa-2	pancreas	COSMIC	SYTGEKVPEI	DEG_COP1_1	0.1389
p.G1846A	IHH-4	thyroid	COSMIC	SYTGEKVPEI	DEG_COP1_1	0.6389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P24821	Tenascin	DEG_COP1_1	1832:1841	SYTGEKVPEI	COP1	0.553	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons