DegronMD

Uniprot ID: Q9BXM0

Source protein: Periaxin

Source gene: PRX

Class: DEG_COP1_1

Location: 558:567

E3 ligase: COP1

DEGRON score: 0.7631

ASA_SCORE: 70.94

COIL: 0.7332

CONS_SCORE: 0.8534

DSS_SCORE: 0.3011

HELIX: 0.0992

FCONS_SCORE: 0.9787

RIG_SCORE: 0.7588

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P575L	TCGA-19-5956	GBM	TCGA	EVSEVAVPEV	DEG_COP1_1	0.1111
p.P575L	DO13863	GBM	ICGC	EVSEVAVPEV	DEG_COP1_1	0.1111
p.E561Q	TCGA-C8-A132	BRCA	TCGA	EVSEVAVPEV	DEG_COP1_1	0.5633
p.E561Q	DO1468	BRCA	ICGC	EVSEVAVPEV	DEG_COP1_1	0.5633
p.E561K	TCGA-EK-A2RA	CESC	TCGA	EVSEVAVPEV	DEG_COP1_1	0.591
p.E561K	DO51601	CESC	ICGC	EVSEVAVPEV	DEG_COP1_1	0.591
p.P557T	DO222427	BTCA	ICGC	EVSEVAVPEV	DEG_COP1_1	0.3056
p.S560P	DO228912	LICA	ICGC	EVSEVAVPEV	DEG_COP1_1	0.5641
p.L548M	DO228948	LICA	ICGC	EVSEVAVPEV	DEG_COP1_1	0.0556
p.V551M	SIDM00501	Oral Cavity Carcinoma	GDSC	EVSEVAVPEV	DEG_COP1_1	0.1389
p.V551M	SIDM00221	Melanoma	GDSC	EVSEVAVPEV	DEG_COP1_1	0.1389
p.V551M	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	EVSEVAVPEV	DEG_COP1_1	0.1389
p.V551M	SIDM00903	Non-Small Cell Lung Carcinoma	GDSC	EVSEVAVPEV	DEG_COP1_1	0.1389
p.V551M	SIDM00902	Non-Small Cell Lung Carcinoma	GDSC	EVSEVAVPEV	DEG_COP1_1	0.1389
p.V551M	SIDM01775	B-Cell Non-Hodgkin's Lymphoma	GDSC	EVSEVAVPEV	DEG_COP1_1	0.1389
p.V564M	SIDM00951	T-Lymphoblastic Leukemia	GDSC	EVSEVAVPEV	DEG_COP1_1	0.7208
p.V564M	ACH-002222	Leukemia	CCLE	EVSEVAVPEV	DEG_COP1_1	0.7208
p.V564M	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	EVSEVAVPEV	DEG_COP1_1	0.7208
p.P557Q	SIDM00220	Ovarian Carcinoma	GDSC	EVSEVAVPEV	DEG_COP1_1	0.3056
p.P557Q	ACH-000962	Ovarian Cancer	CCLE	EVSEVAVPEV	DEG_COP1_1	0.3056
p.P557Q	OC-314	ovary	COSMIC	EVSEVAVPEV	DEG_COP1_1	0.3056
p.A563V	SIDM01608	Endometrial Carcinoma	GDSC	EVSEVAVPEV	DEG_COP1_1	0.5825
p.A563V	ACH-000990	Endometrial/Uterine Cancer	CCLE	EVSEVAVPEV	DEG_COP1_1	0.5825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BXM0	Periaxin	DEG_COP1_1	558:567	EVSEVAVPEV	COP1	0.7631	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons