DegronMD

Uniprot ID: Q69YH5

Source protein: Cell division cycle-associated protein 2

Source gene: CDCA2

Class: DEG_COP1_1

Location: 298:307

E3 ligase: COP1

DEGRON score: 0.9959

ASA_SCORE: 80.22

COIL: 0.8348

CONS_SCORE: 0.3174

DSS_SCORE: 0.4725

HELIX: 0.1018

FCONS_SCORE: 0.84

RIG_SCORE: 0.7155

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D302E	TCGA-37-3792	LUSC	TCGA	EVSSDAVPDV	DEG_COP1_1	0.5647
p.D302E	DO27192	LUSC	ICGC	EVSSDAVPDV	DEG_COP1_1	0.5647
p.V307F	TCGA-49-6743	LUAD	TCGA	EVSSDAVPDV	DEG_COP1_1	0.5957
p.V307F	DO26092	LUAD	ICGC	EVSSDAVPDV	DEG_COP1_1	0.5957
p.T294M	DO228581	GACA	ICGC	EVSSDAVPDV	DEG_COP1_1	0.2222
p.D293Y	DO229028	LICA	ICGC	EVSSDAVPDV	DEG_COP1_1	0.1944
p.A289V	DO222653	MELA	ICGC	EVSSDAVPDV	DEG_COP1_1	0.0833
p.P305H	DO229216	THCA	ICGC	EVSSDAVPDV	DEG_COP1_1	0.7694
p.C315Y	SIDM01016	T-Lymphoblastic Leukemia	GDSC	EVSSDAVPDV	DEG_COP1_1	0.1111
p.C315Y	SIDM01263	T-Lymphoblastic Leukemia	GDSC	EVSSDAVPDV	DEG_COP1_1	0.1111
p.C315Y	ACH-000995	Leukemia	CCLE	EVSSDAVPDV	DEG_COP1_1	0.1111
p.C315Y	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	EVSSDAVPDV	DEG_COP1_1	0.1111
p.C300Y	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	EVSSDAVPDV	DEG_COP1_1	0.7087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q69YH5	Cell division cycle-associated protein 2	DEG_COP1_1	298:307	EVSSDAVPDV	COP1	0.9959	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons