DegronMD - Q69YH5(CDCA2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D302E	TCGA-37-3792	LUSC	TCGA	EVSSDAVPDV	DEG_COP1_1	298:307	Mutation altering degron motif	0.5647
p.D302E	DO27192	LUSC	ICGC	EVSSDAVPDV	DEG_COP1_1	298:307	Mutation altering degron motif	0.5647
p.V307F	TCGA-49-6743	LUAD	TCGA	EVSSDAVPDV	DEG_COP1_1	298:307	Mutation altering degron motif	0.5957
p.V307F	DO26092	LUAD	ICGC	EVSSDAVPDV	DEG_COP1_1	298:307	Mutation altering degron motif	0.5957
p.R510I	TCGA-E6-A1LX	UCEC	TCGA	RRNQLVSVV	DEG_APCC_DBOX_1	509:517	Mutation altering degron motif	0.8102
p.R510I	DO41020	UCEC	ICGC	RRNQLVSVV	DEG_APCC_DBOX_1	509:517	Mutation altering degron motif	0.8102
p.R509I	TCGA-RS-A6TO	HNSC	TCGA	RRNQLVSVV	DEG_APCC_DBOX_1	509:517	Mutation altering degron motif	0.6991
p.R509I	DO219060	HNSC	ICGC	RRNQLVSVV	DEG_APCC_DBOX_1	509:517	Mutation altering degron motif	0.6991
p.V514L	DO224801	COCA	ICGC	RRNQLVSVV	DEG_APCC_DBOX_1	509:517	Mutation altering degron motif	0.5654
p.T294M	DO228581	GACA	ICGC	EVSSDAVPDV	DEG_COP1_1	298:307	Mutation rewiring degron network	0.2222
p.D293Y	DO229028	LICA	ICGC	EVSSDAVPDV	DEG_COP1_1	298:307	Mutation rewiring degron network	0.1944
p.G501C	DO229028	LICA	ICGC	RRNQLVSVV	DEG_APCC_DBOX_1	509:517	Mutation rewiring degron network	0.1111
p.V521F	DO229037	LICA	ICGC	RRNQLVSVV	DEG_APCC_DBOX_1	509:517	Mutation rewiring degron network	0.2222
p.A289V	DO222653	MELA	ICGC	EVSSDAVPDV	DEG_COP1_1	298:307	Mutation rewiring degron network	0.0833
p.V500F	DO34696	PACA	ICGC	RRNQLVSVV	DEG_APCC_DBOX_1	509:517	Mutation rewiring degron network	0.0833
p.P305H	DO229216	THCA	ICGC	EVSSDAVPDV	DEG_COP1_1	298:307	Mutation altering degron motif	0.7694
p.C522F	DO229232	THCA	ICGC	RRNQLVSVV	DEG_APCC_DBOX_1	509:517	Mutation rewiring degron network	0.1944
p.C315Y	SIDM01016	T-Lymphoblastic Leukemia	GDSC	EVSSDAVPDV	DEG_COP1_1	298:307	Mutation rewiring degron network	0.1111
p.C315Y	SIDM01263	T-Lymphoblastic Leukemia	GDSC	EVSSDAVPDV	DEG_COP1_1	298:307	Mutation rewiring degron network	0.1111
p.C315Y	ACH-000995	Leukemia	CCLE	EVSSDAVPDV	DEG_COP1_1	298:307	Mutation rewiring degron network	0.1111
p.C315Y	Jurkat	haematopoietic and lymphoid tissue	COSMIC	EVSSDAVPDV	DEG_COP1_1	298:307	Mutation rewiring degron network	0.1111
p.L525W	SIDM00791	Chronic Myelogenous Leukemia	GDSC	RRNQLVSVV	DEG_APCC_DBOX_1	509:517	Mutation rewiring degron network	0.1111
p.L525W	SIDM00836	Colorectal Carcinoma	GDSC	RRNQLVSVV	DEG_APCC_DBOX_1	509:517	Mutation rewiring degron network	0.1111
p.L525W	SIDM00839	Colorectal Carcinoma	GDSC	RRNQLVSVV	DEG_APCC_DBOX_1	509:517	Mutation rewiring degron network	0.1111
p.L513F	SIDM01076	B-Lymphoblastic Leukemia	GDSC	RRNQLVSVV	DEG_APCC_DBOX_1	509:517	Mutation altering degron motif	0.6981
p.L513F	SIDM00208	Glioblastoma	GDSC	RRNQLVSVV	DEG_APCC_DBOX_1	509:517	Mutation altering degron motif	0.6981
p.C300Y	Jurkat	haematopoietic and lymphoid tissue	COSMIC	EVSSDAVPDV	DEG_COP1_1	298:307	Mutation altering degron motif	0.7087

Kaplan plot for CDCA2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDCA2

UniProt ID: Q69YH5

Entrez ID: 157313

Protein name: Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDCA2 in